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Salivary gland hybrid tumour revisited: could they represent high-grade transformation in a low-grade neoplasm?

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Abstract

Salivary gland hybrid tumour, first described in 1996, is a very rare neoplasm for which exact morphological criteria have not been universally agreed upon. In contrast, the concept of high-grade transformation (HGT) in salivary neoplasms has been widely accepted during the last decade, and the number of reported cases is rapidly increasing. A review of the literature revealed 38 cases of hybrid tumour reported in 22 publications. During approximately the same time period, well over 100 cases of HGT in salivary neoplasms have been reported. There are important histological similarities between hybrid tumours and salivary tumours with HGT. In the latter, containing one tumour component of low-grade malignancy and the other of high grade, the two tumour components are not entirely separated and appear to originate in the same area. Virtually, all cases reported as hybrid tumour had no clear lines of demarcation between the two tumour types. We are inclined to suggest that most of the 38 cases of hybrid tumours described in the literature would today better be called tumour with HGT rather than hybrid tumour. The relative proportion of the two components may vary, and the high-grade component is sometimes very small, which emphasises the importance of very generous sampling of the surgical specimen. The molecular genetic mechanisms responsible for HGT, including what used to be called hybrid tumour, remain largely unknown. Abnormalities of a few genes (including p53, C-MYC, cyclin D1, HER-2/neu) have been documented. As insufficient data exist on gene abnormalities in these lesions, conclusions as to whether or not they have a common origin and which mechanisms are involved in transformation cannot be drawn. Due to the small number of cases reported, many of which lack follow-up details; indicators of prognosis of hybrid tumours are not available, but their behaviour seems to be similar to that of tumours with HGT, i.e. an accelerated aggressive course. HGT of salivary gland neoplasms greatly influences macroscopic and microscopic evaluation of the specimen but also, given the high incidence of metastases and morbidity, carries significant treatment implications.

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References

  1. Ballestin C, Lopez-Carreira M, Lopez JI (1996) Combined acinic cell mucoepidermoid carcinoma of the parotid gland. Report of a case with immunohistochemical study. APMIS 104:99–102

    Article  CAS  PubMed  Google Scholar 

  2. Seifert G, Donath K (1996) Hybrid tumours of salivary glands. Definition and classification of five rare cases. Eur J Cancer B Oral Oncol 32B:251–259

    Article  CAS  PubMed  Google Scholar 

  3. Murphy JGP, Lonsdale R, Premachandra D, Hellquist HB (2006) Salivary hybrid tumour: adenoid cystic carcinoma and basal cell adenocarcinoma. Virchows Arch 448:236–238

    Article  CAS  PubMed  Google Scholar 

  4. Hellquist H, Skalova A (2014) Hybrid tumour in: histopathology of the salivary glands. Springer, Heidelberg, New York, Dordrecht, London, pp. 415–418

    Google Scholar 

  5. Costa AF, Altemani A, Hermsen M (2011) Current concepts of dedifferentiation/high-grade transformation in salivary gland tumors. Patolog Res Int. doi:10.4061/2011/325965

  6. Dahlin DC, Beabout JW (1971) Dedifferentiation of low-grade chondrosarcomas. Cancer 28:461–466

    Article  CAS  PubMed  Google Scholar 

  7. Nagao T (2013) “Dedifferentiation” and high-grade transformation in salivary gland carcinomas. Head Neck Pathol 7(Suppl 1):S37–S47

    Article  PubMed  Google Scholar 

  8. Stanley RJ, Weiland LH, Olsen KD, Pearson BW (1988) Dedifferentiated acinic cell (acinous) carcinoma of the parotid gland. Otolaryngol Head Neck Surg 98:155–161

    Article  CAS  PubMed  Google Scholar 

  9. Barnes EL, Eveson JW, Reichart P, Sidransky D (eds.) Pathology & genetics of head and neck tumours. World Health Organization Classification of Tumours, IARC Press, Lyon, 2005.

  10. Seifert G, Simpson R (1997) Pitfalls in salivary gland pathology: hybrid epithelial-myoepithelial carcinoma and adenoid cystic carcinoma (abstract 067). Pathol Res Pract 193:342

    Article  Google Scholar 

  11. Kamio N, Tanaka Y, Mukai M, Ikeda E, Kuramochi S, Fujii M, Hosoda Y (1997) A hybrid carcinoma: adenoid cystic carcinoma and salivary duct carcinoma of the salivary gland. An immunohistochemical study. Virchows Arch 430:495–500

    Article  CAS  PubMed  Google Scholar 

  12. Croitoru CM, Suarez PA, Luna MA (1999) Hybrid carcinomas of salivary glands. Report of 4 cases and review of the literature. Arch Pathol Lab Med 123:698–702

    CAS  PubMed  Google Scholar 

  13. Snyder ML, Paulino AF (1999) Hybrid carcinoma of the salivary gland: salivary duct adenocarcinoma and adenoid cystic carcinoma. Histopathology 35:380–383

    Article  CAS  PubMed  Google Scholar 

  14. Chetty R, Medley P, Essa A (2000) Hybrid carcinomas of salivary glands. Arch Pathol Lab Med 124:494–496

    CAS  PubMed  Google Scholar 

  15. Zardawi IM (2000) Hybrid carcinoma of the salivary gland. Histopathology 37:283–284

    Article  CAS  PubMed  Google Scholar 

  16. Hayashi K, Shimamoto F, Takata T, Yasui W (2001) Epithelial-myoepithelial carcinoma of the parotid gland with adenoid cystic carcinoma-like features: a case report with immunohistochemical study. Hiroshima J Med Sci 50:101–104

    CAS  PubMed  Google Scholar 

  17. Nagao T, Sugano I, Ishida Y, Asoh A, Munakata S, Yamazaki K, et al. (2002) Hybrid carcinomas of the salivary glands: report of nine cases with clinicopathologic, immunohistochemical, and p53 gene alteration analysis. Mod Pathol 15:724–733

    Article  PubMed  Google Scholar 

  18. Ruiz-Godoy LM, Mosqueda-Taylor A, Suarez-Roa L, Poitevin A, Bandala-Sanchez E, Memeses-Garcia A (2003) Hybrid tumours of the salivary glands. A report of two cases involving the palate and a review of the literature. Eur Arch Otorhinolaryngol 260:312–315

    Article  PubMed  Google Scholar 

  19. Woo JS, Kwon SY, Jung KY, Kim I (2004) A hybrid carcinoma of epithelial-myoepithelial carcinoma and adenoid cystic carcinoma in maxillary sinus. J Korean Med Sci 19:462–465

    Article  PubMed  PubMed Central  Google Scholar 

  20. Piana S, Damiani S, Asioli S, Magrini E, Barberi W, Cavazza A (2004) Epstein-Barr positive lymphoepithelial carcinoma and epi-myopeithelial cell carcinoma of the parotid gland: a hitherto unreported example of hybrid tumour. Virchows Arch 445:425–428

    Article  PubMed  Google Scholar 

  21. Mosqueda-Taylor A, Cano-Valdéz AM, Ruiz-González JD, Ortega-Gutiérrez C, Luna-Ortiz K (2010) Hybrid salivary gland tumor of the upper lip or just an adenoid cystic carcinoma? Case report. Med Oral Patol Oral Cir Bucal 15:e43–e47

    PubMed  Google Scholar 

  22. Kainuma K, Oshima A, Suzuki H, Fukushima M, Shimojo H, Usami S (2010) Hybrid carcinoma of the parotid gland: report of a case (epithelial-myoepithelial carcinoma and salivary duct carcinoma) and review of the literature. Acta Otolaryngol 130:185–189

    Article  PubMed  Google Scholar 

  23. Falbo V, Floridia G, Censi F, Marra M, Foschini MP, Taruscio D (2011) Three cases of rare salivary gland tumours: a molecular study of TP53, CDKN2A/ARF, RAS, BRAF, PTEN, MAPK2 and EGFR genes. Oncol Rep 26:3–11

    CAS  PubMed  Google Scholar 

  24. Eichhorn W, Precht C, Wehrmann M, Hickmann E, Eichhorn M, Zeuch J, Löning T, Friedrich RE, Heiland M, Hoffmann J (2013) First description of a hybrid tumor of the sublingual gland. Anticancer Res 33:4567–4571

    PubMed  Google Scholar 

  25. Karasmanis I, Goudakos JK, Vital I, Zarampoukas T, Vital V, Markou K (2013) Hybrid carcinoma of the larynx: a case report (adenoid cystic and adenocarcinoma) and review of the literature. Case Rep Otolaryngol. doi:10.1155/2013/385405

    PubMed  PubMed Central  Google Scholar 

  26. Atay G, Cabbarzade C, Gedikoglu G, Hosal AS (2014) Hybrid carcinoma of the parotid gland: ductal carcinoma and myoepithelial carcinoma. Kulak Burun Bogaz Ihtis Derg 24:46–49 [Turkish with English Abstract]

    Article  PubMed  Google Scholar 

  27. Sabri A, Bawab I, Khalifeh I, Alam E (2015) Hybrid tumor of the parotid gland: a case report and review of the literature. Case Rep Otolaryngol. doi:10.1155/2015/192453

    PubMed  PubMed Central  Google Scholar 

  28. Tran TAN, Jennings T, Carlson JA (2015) Dedifferentiated salivary hybrid carcinoma of the maxillary sinus with Pagetoid spread to the overlying lining mucosa. Head Neck Pathol 9:293–299

    Article  PubMed  Google Scholar 

  29. Henley JD, Geary WA, Jackson CL, Wu CD, Gnepp DR (1997) Dedifferentiated acinic cell carcinoma of the parotid gland: a distinct rarely described entity. Hum Pathol 28:869–873

    Article  CAS  PubMed  Google Scholar 

  30. Di Palma S, Corletto V, Lavarino C, Birindelli S, Pilotti S (1999) Unilateral aneuploid dedifferentiated acinic cell carcinoma associated with bilateral low grade diploid acinic cell carcinoma of the parotid gland. Virchows Arch 434:361–365

    Article  CAS  PubMed  Google Scholar 

  31. Skálová A, Sima R, Vanecek T, Muller S, Korabecna M, Nemcova J, Elmberger G, Leivo I, Passador-Santos F, Walter J, Rousarova M, Jedlickova K, Curik R, Geierova M, Michal M (2009) Acinic cell carcinoma with high-grade transformation: a report of 9 cases with immunohistochemical study and analysis of TP53 and HER-2/neu genes. Am J Surg Pathol 33:1137–1145

    Article  PubMed  Google Scholar 

  32. Ilayaraja V, Prasad H, Anuthama K, Sruthi R (2014) Acinic cell carcinoma of minor salivary gland showing features of high-grade transformation. J Oral Maxillofac Pathol 18:97–101

    Article  PubMed  PubMed Central  Google Scholar 

  33. Thompson LD, Aslam MN, Stall JN, Udager AM, Chiosea S, McHugh JB (2015) Clinicopathologic and immunophenotypic characterization of 25 cases of acinic cell carcinoma with high-grade transformation. Head Neck Pathol 10:152–160

    Article  PubMed  PubMed Central  Google Scholar 

  34. Chintakuntlawar AV, Shon W, Erickson-Johnson M, Bilodeau E, Jenkins SM, Davidson JA, Keeney MG, Rivera M, Price DL, Moore EJ, Olsen KD, Kasperbauer JL, Foote RL, Price KA, Garcia JJ (2016) High-grade transformation of acinic cell carcinoma: an inadequately treated entity? Oral Surg Oral Med Oral Pathol Oral Radiol 121:542–549

    Article  PubMed  Google Scholar 

  35. Cheuk W, Chan JKC, Ngan RKC (1999) Dedifferentiation in adenoid cystic carcinoma of salivary gland. An uncommon complication associated with an accelerated clinical course. Am J Surg Pathol 23:465–472

    Article  CAS  PubMed  Google Scholar 

  36. Moles MA, Avila IR, Archila AR (1999) Dedifferentiation occurring in adenoid cystic carcinoma of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 88:177–180

    Article  CAS  PubMed  Google Scholar 

  37. Terasaki M, Tokutomi T, Maruiwa H, Sugita Y, Harada H, Shigemori M (2000) High-grade adenoid cystic carcinoma originating from the lacrimal gland. Brain Tumor Pathol 17:159–163

    Article  CAS  PubMed  Google Scholar 

  38. Chau Y, Hongyo T, Aozasa K, Chan JK (2001) Dedifferentiation of adenoid cystic carcinoma: report of a case implicating p53 gene mutation. Hum Pathol 32:1403–1407

    Article  CAS  PubMed  Google Scholar 

  39. Ide F, Mishima K, Saito I (2003) Small foci of high-grade carcinoma cells in adenoid cystic carcinoma represent an incipient phase of dedifferentiation. Histopathology 43:604–606

    Article  CAS  PubMed  Google Scholar 

  40. Nagao T, Gaffey TA, Serizawa H, Sugano I, Ishida Y, Yamazaki K, Tokashiki R, Yoshida T, Minato H, Kay PA, Lewis JE (2003) Dedifferentiated adenoid cystic carcinoma: a clinicopathologic study of 6 cases. Mod Pathol 16:1265–1272

    Article  PubMed  Google Scholar 

  41. Brackrock S, Krüll A, Röser K, Schwarz R, Riethdorf L, Alberti W (2005) Neutron therapy, prognostic factors and dedifferentiation of adenoid cystic carcinomas (ACC) of salivary glands. Anticancer Res 25:1321–1326

    PubMed  Google Scholar 

  42. Sato K, Ueda Y, Sakurai A, Ishikawa Y, Kaji S, Nojima T, Katsuda S (2006) Adenoid cystic carcinoma of the maxillary sinus with gradual histologic transformation to high-grade adenocarcinoma: a comparative report with dedifferentiated carcinoma. Virchows Arch 448:204–208

    Article  PubMed  Google Scholar 

  43. Seethala RR, Hunt JL, Baloch ZW, Livolsi VA, Barnes EL (2007) Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature. Am J Surg Pathol 31:1683–1694

    Article  PubMed  Google Scholar 

  44. Handra-Luca A, Planchard D, Fouret P (2009) Docetaxel-cisplatin-radiotherapy in adenoid cystic carcinoma with high-grade transformation. Oral Oncol 45:e208–e209

    Article  PubMed  Google Scholar 

  45. Malhotra KP, Agrawal V, Pandey R (2009) High grade transformation in adenoid cystic carcinoma of the parotid: report of a case with cytologic, histologic and immunohistochemical study. Head Neck Pathol 3:310–314

    Article  PubMed  PubMed Central  Google Scholar 

  46. Bonfitto VL, Demasi AP, Costa AF, Bonfitto JF, Araujo VC, Altemani A (2010) High-grade transformation of adenoid cystic carcinomas: a study of the expression of GLUT1 glucose transporter and of mitochondrial antigen. J Clin Pathol 63:615–619

    Article  CAS  PubMed  Google Scholar 

  47. Costa AF, Altemani A, Vékony H, Bloemena E, Fresno F, Suárez C, et al. (2011) Genetic profile of adenoid cystic carcinomas (ACC) with high grade transformation versus solid type. Cell Oncol 34:369–379

    Article  CAS  Google Scholar 

  48. Panarelli JF, Zoumalan CI, Mukkamala K, Maher EA, Iacob C, Della Rocca DA (2011) Dedifferentiated adenoid cystic carcinoma of the lacrimal gland. Ophthal Plast Reconstr Surg 27:e119–e121

    Article  PubMed  Google Scholar 

  49. Boland JM, McPhail ED, García JJ, Lewis JE, Schembri-Wismayer DJ (2012) Detection of human papilloma virus and p16 expression in high-grade adenoid cystic carcinoma of the head and neck. Mod Pathol 25:529–236

    Article  PubMed  Google Scholar 

  50. Argyris PP, Pambuccian SE, Cayci Z, Singh C, Tosios KI, Koutlas IG (2013) Lacrimal gland adenoid cystic carcinoma with high-grade transformation to myoepithelial carcinoma: report of a case and review of the literature. Head Neck Pathol 7:85–92

    Article  PubMed  Google Scholar 

  51. Bayle RM, D’Mello S, Makaria S, Hosthor SS (2013) Dedifferentiation in adenoid cystic carcinoma. J Oral Maxillofac Pathol 17:474–477

    Article  Google Scholar 

  52. Ly CK, Cheng HM, Vermeulen T (2013) High grade transformation in a case of adenoid cystic carcinoma associated with Epstein-Barr virus expression. Pathology 45:693–695

    Article  PubMed  Google Scholar 

  53. Sayar H, Sarioȗğlu S, Bakaris S, Yildirim I, Öztarakçi H (2013) High-grade transformation of adenoid cystic carcinoma delineated with a fibrous rim: a case report. Balkan Med J 30:333–336

    Article  PubMed  PubMed Central  Google Scholar 

  54. Alos L, Carrillo R, Ramos J, Baez JM, Mallofre C, Fernandez PL, Cardesa A (1999) High-grade carcinoma component in epithelial-myoepithelial carcinoma of salivary glands clinicopathological, immunohistochemical and flow-cytometric study of three cases. Virchows Arch 434:291–299

    Article  CAS  PubMed  Google Scholar 

  55. Seethala RR, Barnes EL, Hunt JL (2007) Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol 31:44–57

    Article  PubMed  Google Scholar 

  56. Kusafuka K, Takizawa Y, Ueno T, Ishiki H, Asano R, Kamijo T, Iida Y, Ebihara M, Ota Y, Onitsuka T, Kameya T (2008) Dedifferentiated epithelial-myoepithelial carcinoma of the parotid gland: a rare case report of immunohistochemical analysis and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:85–91

    Article  PubMed  Google Scholar 

  57. Roy P, Bullock MJ, Perez-Ordoñez B, Dardick I, Weinreb I (2010) Epithelial-myoepithelial carcinoma with high grade transformation. Am J Surg Pathol 34:1258–1265

    Article  PubMed  Google Scholar 

  58. Aydin S, Taskin U, Ozdamar K, Yücebas K, Sar M, Oktay MF, Tetikkurt ÜS (2014) Case study of a parotid gland adenocarcinoma dedifferentiated from epithelial-myoepithelial carcinoma. Case Rep Otolaryngol. doi:10.1155/2014/629054

    PubMed  PubMed Central  Google Scholar 

  59. Lloreta J, Serrano S, Corominas JM, Ferrés-Padró E (1995) Polymorphous low-grade adenocarcinoma arising in the nasal cavities with an associated undifferentiated carcinoma. Ultrastruct Pathol 19:365–370

    Article  CAS  PubMed  Google Scholar 

  60. Pelkey TJ, Mills SE (1999) Histologic transformation of polymorphous low-grade adenocarcinoma of salivary gland. Am J Clin Pathol 111:785–791

    Article  CAS  PubMed  Google Scholar 

  61. Simpson RH, Pereira EM, Ribeiro AC, Abdulkadir A, Reis-Filho JS (2002) Polymorphous low-grade adenocarcinoma of the salivary glands with transformation to high-grade carcinoma. Histopathology 41:250–259

    Article  CAS  PubMed  Google Scholar 

  62. Nagao T, Gaffey TA, Kay PA, Unni KK, Nascimento AG, Sebo TJ, et al. (2003) Dedifferentiation in low-grade mucoepidermoid carcinoma of the parotid gland. Hum Pathol 34:1068–1072

    Article  PubMed  Google Scholar 

  63. Ogawa I, Nishida T, Miyauchi M, Sato S, Takata T (2003) Dedifferentiated malignant myoepithelioma of the parotid gland. Pathol Int 53:704–709

    Article  PubMed  Google Scholar 

  64. Subramaniam MM, Ng SB, Seah SB, Anuar D, Soong R, Lee VK (2009) Molecular characterization of dedifferentiated mucoepidermoid carcinoma of the trachea using laser microdissection-based PT53 mutation analysis. Histopathology 55:4722–4475

    Article  Google Scholar 

  65. O'Regan E, Shandilya M, Gnepp DR, Timon C, Toner M (2004) Hyalinizing clear cell carcinoma of salivary gland: an aggressive variant. Ral Oncol 40:348–350

    Google Scholar 

  66. Jin R, Craddock KJ, Irish JC, Perez-Ordonez B, Weinreb I (2012) Recurrent hyalinizing clear cell carcinoma of the base of tongue with high-grade transformation and EWSR1 gene rearrangement by FISH. Head Neck Pathol 6:389–394

    Article  PubMed  PubMed Central  Google Scholar 

  67. Skalova A, Vanecek T, Majewska H, Laco J, Grossmann P, Simpson RHW, et al. (2014) Mammary analogue secretory carcinoma of salivary glands with high grade transformation: report of three cases with the ETV6-NTRK3 gene fusion and analysis of TP53, β-catenin, EGFR and CCND1 genes. Am J Surg Pathol 38:23–33

    Article  PubMed  Google Scholar 

  68. Luo W, Lindley SW, Lindley PH, Krempl GA, Seethala RR, Fung K-M (2014) Mammary analog secretary carcinoma of salivary gland with high-grade histology arising in hard palate, report of a case and review of the literature. Int J Clin Exp Pathol 7:9008–9022

    PubMed  PubMed Central  Google Scholar 

  69. Hellquist H, Skálová A, Barnes L, Cardesa A, Thompson LDR, Triantafyllou A, et al. (2016) Cervical lymph node metastasis in high-grade transformation of head and neck adenoid cystic carcinoma: a collective international review. Adv Ther 33:357–368

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Seethala RR, Cieply K, Barnes EL, Dacic S (2011) Progressive genetic alterations of adenoid cystic carcinoma with high-grade transformation. Arch Pathol Lab Med 135:123–130

    PubMed  Google Scholar 

  71. Hellquist H, Skalova A (2014) Acinic cell carcinoma in: histopathology of the salivary glands. Springer, Heidelberg, New York, Dordrecht, London, pp. 261–281

    Google Scholar 

  72. Di Palma S (1994) Epithelial-myoepithelial carcinoma with co-existing multifocal intercalated duct hyperplasia of the parotid gland. Histopathology 25:494–496

    Article  CAS  PubMed  Google Scholar 

  73. Chetty R (2000) Intercalated duct hyperplasia: possible relationship to epithelial-myoepithelial carcinoma and hybrid tumours of salivary gland. Histopathology 37:260–263

    Article  CAS  PubMed  Google Scholar 

  74. Weinreb I, Seethala RR, Hunt JL, Chetty R, Dardick I, Perez-Ordoñez B (2009) Intercalated duct lesions of salivary gland: a morphologic spectrum from hyperplasia to adenoma. Am J Surg Pathol 33:1322–1329

    Article  PubMed  Google Scholar 

  75. Naunheim MR, Lin HW, Faquin WC, Lin DT (2012) Intercalated duct lesion of the parotid. Head Neck Pathol 6:373–337

    Article  PubMed  PubMed Central  Google Scholar 

  76. Grenko RT, Abendroth CS, Davis AT, Levin RJ, Dardick I (1998) Hybrid tumors of salivary gland tumors sharing common differentiation pathways? Reexamining adenoid cystic and epithelial-myoepithelial carcinomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 86:188–195

    Article  CAS  PubMed  Google Scholar 

  77. Padmanabhan V, Cooper K (2000) Concomitant adenoma and hybrid carcinoma of salivary gland type arsing in Bartholin’s gland. Int J Gynecol Pathol 19:377–380

    Article  CAS  PubMed  Google Scholar 

  78. Hellquist H, Skalova A (2014) Carcinoma ex pleomorphic adenoma in: histopathology of the salivary glands. Springer, Heidelberg, New York, Dordrecht, London, pp. 283–296

    Google Scholar 

  79. Petersson F (2015) High-grade transformation (“dedifferentiation”) – malignant progression of salivary gland neoplasms, including carcinoma ex pleomorphic adenoma. Pathology Case Reviews 20:27–37

    Article  Google Scholar 

  80. Costa AF, Altemani A, García-Inclán C, Fresno F, Suárez C, Llorente JL, Hermsen M (2014) Analysis of MYB oncogene in transformed adenoid cystic carcinomas reveals distinct pathways of tumor progression. Lab Investig 94:692–702

    Article  CAS  PubMed  Google Scholar 

  81. Gupta R, Balasubramanian D, Clark JR (2015) Salivary gland lesions: recent advances and evolving concepts. Oral Surg Oral Med Oral Pathol Oral Radiol 119:661–674

    Article  PubMed  Google Scholar 

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  1. Department of Biomedical Sciences and Medicine, University of Algarve, Campus de Gambelas, 8005-139, Faro, Portugal

    Henrik Hellquist

  2. Department of Pathology, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic

    Alena Skalova

  3. Department of Pathology, Glan Clwyd Hospital, Rhyl, UK

    Bahram Azadeh

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Hellquist, H., Skalova, A. & Azadeh, B. Salivary gland hybrid tumour revisited: could they represent high-grade transformation in a low-grade neoplasm?. Virchows Arch 469, 643–650 (2016). https://doi.org/10.1007/s00428-016-2018-6

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