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Recent advances in the diagnostic pathology of salivary carcinomas

  • Review and Perspectives
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Abstract

This review concentrates on the most important developments since the WHO classification of 2005. In particular, the identification of specific translocations is revolutionising the way salivary tumours are considered and will have a major impact on future diagnostic practice. This is true so far in four malignancies: mammary analogue secretory, mucoepidermoid, adenoid cystic and hyalinising clear cell carcinomas. In each, the gene rearrangement is found in 80 % or more of cases. Two 2014 publications have added further possible candidates with molecular abnormalities to the list (cribriform adenocarcinoma of the tongue and minor salivary glands and epithelial-myoepithelial carcinoma), but these findings have yet to be confirmed by other investigators. The advances in molecular pathology have also allowed re-evaluation of the morphology; for example, it is now realised that the histological spectrum of hyalinising clear cell carcinoma includes intracellular mucin in over half of cases, as well as tumours with only scanty clear cells. In a separate development, it is now proposed that salivary duct carcinoma can be subdivided along molecular lines, in ways analogous to breast cancer, suggesting new therapeutic prospects in an otherwise highly aggressive malignancy.

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The authors declare that they have no conflict of interest in this paper.

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Authors and Affiliations

  1. Department of Anatomical Pathology, University of Calgary, 11th Floor, Foothills Medical Centre, 1403, 29th Street NW, Calgary, Alberta, T2N 2T9, Canada

    Roderick H. W. Simpson

  2. Faculty of Medicine in Plzeň, Charles University in Prague, Prague 1, Czech Republic

    Alena Skálová

  3. Royal Surrey County Hospital, Guildford, Surrey, UK

    Silvana Di Palma

  4. University of Turku, Turku, Finland

    Ilmo Leivo

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  1. Roderick H. W. Simpson
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  2. Alena Skálová
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  3. Silvana Di Palma
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  4. Ilmo Leivo
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Correspondence to Roderick H. W. Simpson.

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Simpson, R.H.W., Skálová, A., Di Palma, S. et al. Recent advances in the diagnostic pathology of salivary carcinomas. Virchows Arch 465, 371–384 (2014). https://doi.org/10.1007/s00428-014-1639-x

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  • DOI: https://doi.org/10.1007/s00428-014-1639-x

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