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Laser speckle flowgraphy has comparable accuracy to indocyanine green fluorescence angiography in assessing bowel blood perfusion

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Abstract

Purpose

To investigate the accuracy of laser speckle flowgraphy (LSFG), a noninvasive method for the quantitative evaluation of blood flow using mean blur rate (MBR) as a blood flow parameter in the assessment of bowel blood perfusion compared to indocyanine green fluorescence angiography (ICG-FA).

Methods

We enrolled 46 patients who underwent left-sided colorectal surgery. LSFG and ICG-FA were applied to assess blood bowel perfusion, with MBR and luminance as parameters, respectively. In both measurement methods, the position where the parameter suddenly decreased was defined as the blood flow boundary line. Subsequently, the blood flow boundaries created after processing the blood vessels flowing into the intestinal tract were determined using LSFG and ICG-FA, and concordance between the two was examined. Blood flow boundaries were visually identified using color tone changes on a color map created based on MBR in LSFG and using differences in luminance in ICG-FA. The distances between the transection line and blood flow boundaries determined using each method were compared.

Results

The location of blood flow boundaries matched in 65% (30/46) of cases. Although locations differed in the remaining 35% (16/46), all were located on the anal side near the transection line, and the difference was not clinically significant. The average distances between the transection line and blood flow boundary were 2.76 (SD = 3.25) and 3.71 (SD = 4.26) mm, respectively. There was no statistically significant difference between the two groups (p = 0.38).

Conclusion

LSFG was shown to have comparable accuracy to ICG-FA, and may be useful for evaluating bowel perfusion.

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Data availability

No datasets were generated or analysed during the current study.

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Acknowledgements

We would like to thank Editage (www.editage.jp), for English language editing.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Toho University Omori Medical Center, 6-11-1 Omori-Nishi, Ota, Tokyo, 143-8541, Japan

    Tomoaki Kaneko, Kimihiko Funahashi, Yuko Ito, Mitsunori Ushigome, Satoru Kagami, Kimihiko Yoshida, Takayuki Suzuki, Yasuyuki Miura & Akiharu Kurihara

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  1. Tomoaki Kaneko
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  2. Kimihiko Funahashi
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  3. Yuko Ito
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  4. Mitsunori Ushigome
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  5. Satoru Kagami
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  6. Kimihiko Yoshida
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  7. Takayuki Suzuki
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  8. Yasuyuki Miura
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  9. Akiharu Kurihara
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Contributions

T.K, and K.F established a study conception and design.

M.U, K.Y, Y.M and A.K acquired the data.

S.K,Y.I and T.S analyzed and interpreted the data.

T.K prepared the manuscript.

K.F revised the manuscript.

Corresponding author

Correspondence to Tomoaki Kaneko.

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Ethics approval

This study was approved by the Ethics Committee of Toho University Omori Hospital (M17229).

Informed consent

Written informed consent was obtained from all subjects involved in the study.

Competing interests

The authors declare no competing interests.

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Kaneko, T., Funahashi, K., Ito, Y. et al. Laser speckle flowgraphy has comparable accuracy to indocyanine green fluorescence angiography in assessing bowel blood perfusion. Langenbecks Arch Surg 409, 147 (2024). https://doi.org/10.1007/s00423-024-03338-4

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  • DOI: https://doi.org/10.1007/s00423-024-03338-4

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