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Prognostic significance of common hepatic artery lymph node metastasis in gastric cancer

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Abstract

Purpose

The number of lymph nodes is used to determine the prognosis in patients with gastric cancer undergoing D2 lymph node dissection. However, a group of extraperigastric lymph nodes, including lymph node 8a, are also considered to be effective in prognosis. In our clinical experience, in most patients during D2 lymph node dissection, the lymph nodes are removed en-bloc with the specimen and are not marked separately. The aim was to analyze the importance and prognostic impact of 8a lymph node metastasis in patients with gastric cancer.

Methods

Patients who underwent gastrectomy and D2 lymph node dissection for gastric cancer between 2015 and 2022 were included in the study. Patients were divided into two groups based on metastasis to the 8a lymph node: metastatic and nonmetastatic. The effect of clinicopathologic features and the prevalence of lymph node metastasis on the prognosis of the two groups were analyzed.

Results

The present study included 78 patients. The mean number of dissected lymph nodes was 27 (IQR, 15–62). There were 22 (28.2%) patients in the 8a lymph node metastatic group. Patients with 8a lymph node metastatic disease had shorter overall survival and shorter disease-free survival. Those with metastatic 8a lymph nodes among pathologic N2/3 patients had shorter overall and disease-free survival rates (p < 0.05).

Conclusion

In conclusion, we believe that anterior common hepatic artery (8a) LN metastasis is a key factor that negatively affects both disease-free and overall survival in patients with locally advanced gastric cancer.

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Data availability

The data are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Department of Surgical Oncology, Sakarya University Training and Research Hospital, Sakarya, Turkey

    Mevlut Yordanagil, Metin Ercan & Adem Senturk

  2. Department of Pathology, Sakarya University Training and Research Hospital, Sakarya, Turkey

    Bilge Elcin

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  1. Mevlut Yordanagil
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  2. Metin Ercan
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Contributions

Mevlut Yordanagil: study conception and design, drafting of manuscript, critical revision of manuscript. Metin Ercan: study conception and design, critical revision of manuscript. Adem Senturk: analysis and interpretation of data, drafting of manuscript. Bilge Elcin: acquisition of data, analysis and interpretation of data.

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Correspondence to Mevlut Yordanagil.

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The approval numbered E-71522473 was obtained from the Ethics Committee of the University.

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Yordanagil, M., Ercan, M., Senturk, A. et al. Prognostic significance of common hepatic artery lymph node metastasis in gastric cancer. Langenbecks Arch Surg 408, 247 (2023). https://doi.org/10.1007/s00423-023-02996-0

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