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Factors affecting diabetic patient’s long-term quality of life after simultaneous pancreas-kidney transplantation: a single-center analysis

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Abstract

Purpose

Pancreas transplantation (PT) is one of the few ways to restore euglycemia within diabetic patients; however, the high morbidity caused by surgical complications and the need for immunosuppressive therapy has raised controversy about PT improving the health-related quality-of-life (HRQoL). The aim of this study is to assess the long-term (≥ 5 years after PT) HRQoL and to identify the factors affecting it.

Methods

A single-center, cross-sectional study of 49 sequential PT was performed. All patients conducted a telephone interview to fulfill the modification of Medical Outcome Health Survey Short Form questionnaire (SF-36v2) and were compared to similar post-PT studies from the literature.

Results

Patients with a history of replacement renal therapy (RRT) or neuropathy undergoing a PT were associated to a worse bodily pain (P = 0.03) and physical function (P = 0.04), respectively, whereas those with retinopathy showed an improved Role Emotional (P = 0.04). Multivariate analysis revealed the presence of RRT as the only independent prognostic factor for a worse bodily pain [relative risk = 3.9; 95% confidence interval (1.1–14.6)], (P = 0.04). Furthermore, nearly all PT recipients (91.8%) claimed an overall better health than prior to PT.

Conclusion

Our study confirms that PT recipients’ HRQoL improves after PT, showing similar HRQoL scores across different populations and suggests that patients in predialysis could benefit from an improved HRQoL if transplanted on the early stages of the disease.

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Author information

Author notes

  1. Luis Muñoz-Bellvís and Javier I. Muñoz-González have equally contributed to this work and they should both be considered “joint senior authors.”

Authors and Affiliations

  1. Department of General and Gastrointestinal Surgery, Pancreas Transplant Program, Hospital Universitario de Salamanca, Salamanca, Spain

    Jaime López-Sánchez, Carmen Esteban, Manuel J. Iglesias, Luis M. González, José E. Quiñones, Juan I. González-Muñoz & Luis Muñoz-Bellvís

  2. Biomedical Research Institute of Salamanca (IBSAL), Universidad de Salamanca, Salamanca, Spain

    Jaime López-Sánchez, Carmen Esteban, Manuel J. Iglesias, Luis M. González, José E. Quiñones, Juan I. González-Muñoz, Javier I. Muñoz-González & Luis Muñoz-Bellvís

  3. Department of Nephrology, Hospital Universitario de Salamanca, Salamanca, Spain

    Guadalupe Tabernero & Pilar Fraile

  4. Department of Endocrinology, Hospital Universitario de Salamanca, Salamanca, Spain

    Rosa A. Iglesias

  5. Cancer Research Center (IBMCC, USAL-CSIC), Department of Medicine and Cytometry Service (NUCLEUS), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Universidad de Salamanca, Salamanca, Spain

    Javier I. Muñoz-González

  6. Department of Surgery, Hospital Universitario de Salamanca, Paseo San Vicente, 88-132, 37007, Salamanca, Spain

    Luis Muñoz-Bellvís

Authors
  1. Jaime López-Sánchez
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  2. Carmen Esteban
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  3. Manuel J. Iglesias
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  4. Luis M. González
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  5. José E. Quiñones
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  6. Juan I. González-Muñoz
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  7. Guadalupe Tabernero
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  8. Rosa A. Iglesias
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  9. Pilar Fraile
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  10. Javier I. Muñoz-González
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  11. Luis Muñoz-Bellvís
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Contributions

J. L-S performed data collection, analyzed the data, and wrote the manuscript; CE, MI, LG, JQ, JI. G-M, GT, RAI, and PF provided patient’s clinical data, performed data collection, and reviewed the manuscript; JI. M-G supported the statistical analyses, analyzed the data, and wrote the manuscript; L. M-B designed the study, analyzed the data, and wrote the manuscript.

Corresponding author

Correspondence to Luis Muñoz-Bellvís.

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The authors declare that they have no conflict of interest.

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The study was approved by the local institutional Ethics Committees. No organs/tissues were obtained from prisoners.

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López-Sánchez, J., Esteban, C., Iglesias, M.J. et al. Factors affecting diabetic patient’s long-term quality of life after simultaneous pancreas-kidney transplantation: a single-center analysis. Langenbecks Arch Surg 406, 873–882 (2021). https://doi.org/10.1007/s00423-020-02059-8

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  • DOI: https://doi.org/10.1007/s00423-020-02059-8

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