Skip to main content

Advertisement

SpringerLink
Log in

Do hairdressers comprise a high risk group for genotoxicity? A systematic review

  • Review
  • Published:
International Archives of Occupational and Environmental Health Aims and scope Submit manuscript

Abstract

Background and objectives

Nowadays, hair dye products are widely used for aesthetic purposes, in which it generates chemical exposure to customers and, mainly, hairdressers. The aim of this systematic review was designed to elucidate the following question: are hair dye products able to induce DNA damage in hairdressers?

Methods

Studies were included in our analyses if they met the following criteria: (1) studies measuring genetic damage in vivo; (2) studies published in English; (3) studies that provided data clearly presented in scientific standards.

Results

Full manuscripts from 13 studies were carefully selected in this setting. Our results demonstrate that hair dye products may contain chemical agents able to induce DNA strand breaks or chromosome damage since the majority of studies demonstrated positive findings for genotoxicity. A total of 7 studies (out of 13) had strong or moderate rates in the quality assessment. The type of genotoxicity assay and sample selection criteria time influenced the outcome.

Conclusion

In summary, our results reveal that hairdressers are occupationally exposed to genotoxic agents. Such findings are very important for protecting these professionals who are continuously exposed to chemicals for long periods.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Availability of data and materials

Data sharing are not available to this article.

References

  • Aglan MA, Mansour GN (2020) Hair straightening products and the risk of occupational formaldehyde exposure in hairstylists. Drug ChemToxicol 43(5):488–495. https://doi.org/10.1080/01480545.2018.1508215

    Article  CAS  Google Scholar 

  • Aslantürk ÖS, AşkinÇelik T (2017) Genotoxic risk assessment in professionals working hairdressers area using buccal micronucleus assay, in Aydın City. Turkey Environ SciPollut Res Int 24(17):14700–14705. https://doi.org/10.1007/s11356-017-9075-5

    Article  CAS  Google Scholar 

  • Bolognesi C, Knasmueller S, Nersesyan A, Thomas P, Fenech M (2013) The HUMNxl scoring criteria for different cell types and nuclear anomalies in the buccal micronucleus cytome assay - an update and expanded photogallery. Mutat Res 753(2):100–113

    Article  CAS  Google Scholar 

  • Bonassi S, El-Zein R, Bolognesi C, Fenech M (2011) Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies. Mutagenesis 26(1):93–100. https://doi.org/10.1093/mutage/geq075. (PMID: 21164188)

    Article  CAS  Google Scholar 

  • Butera A, Amelio I (2023) Healthy lifestyle? or just the right genetic mutations. Cell Cycle 22(11):1353–1356

    Article  CAS  Google Scholar 

  • Carlin V, Fracalossi AC, Miranda SR, Noguti J, Pereira da Silva VH, Oshima CT, Ribeiro DA (2013) Chromosome breakage and cellular death are induced in oral epithelial cells of hairdressers: a preliminary study. ToxicolMech Methods 23(2):108–112. https://doi.org/10.3109/15376516.2012.721810

    Article  CAS  Google Scholar 

  • Cavallo D, Ursini CL, Setini A, Chianese C, Cristaudo A, Iavicoli S (2005) DNA damage and TNFalpha cytokine production in hairdressers with contact dermatitis. Contact Dermatitis 53(3):125–129. https://doi.org/10.1111/j.0105-1873.2005.00672.x

    Article  CAS  Google Scholar 

  • Collins A, Møller P, Gajski G, Vodenková S, Abdulwahed A, Anderson D, Bankoglu EE, Bonassi S, Boutet-Robinet E, Brunborg G, Chao C, Cooke MS, Costa C, Costa S, Dhawan A, de Lapuente J, Bo’ CD, Dubus J, Dusinska M, Duthie SJ, Yamani NE, Engelward B, Gaivão I, Giovannelli L, Godschalk R, Guilherme S, Gutzkow KB, Habas K, Hernández A, Herrero O, Isidori M, Jha AN, Knasmüller S, Kooter IM, Koppen G, Kruszewski M, Ladeira C, Laffon B, Larramendy M, Hégarat LL, Lewies A, Lewinska A, Liwszyc GE, de Cerain AL, Manjanatha M, Marcos R, Milić M, de Andrade VM, Moretti M, Muruzabal D, Novak M, Oliveira R, Olsen AK, Owiti N, Pacheco M, Pandey AK, Pfuhler S, Pourrut B, Reisinger K, Rojas E, Rundén-Pran E, Sanz-Serrano J, Shaposhnikov S, Sipinen V, Smeets K, Stopper H, Teixeira JP, Valdiglesias V, Valverde M, van Acker F, van Schooten FJ, Vasquez M, Wentzel JF, Wnuk M, Wouters A, Žegura B, Zikmund T, Langie SAS, Azqueta A (2023) Measuring DNA modifications with the comet assay: a compendium of protocols. Nat Protoc 18(3):929–989

    Article  CAS  Google Scholar 

  • Cordelli E, Bignami M, Pacchierotti F (2021) Comet assay: a versatile but complex tool in genotoxicity testing. Toxicol Res (camb) 10(1):68–78

    Article  Google Scholar 

  • Espinoza F, Silverman D, Kogevinas M, Creus A, Fernández F, García-Closas M, Tardon A, García-Closas R, Serra C, Carrato A, Rothman N, Dosemeci M, Malats N, Marcos R (2008) Micronuclei assessment in the urothelial cells of women using hair dyes and its modulation by genetic polymorphisms. Cancer Lett 263(2):259–266. https://doi.org/10.1016/j.canlet.2008.01.010

    Article  CAS  Google Scholar 

  • Farhadi S, Jolehar M, Safapour F (2018) Micronucleus assay of buccal mucosal cells in hairdressers: the importance of occupational exposure. Asian Pac J Cancer Prev 19(8):2131–2134. https://doi.org/10.22034/APJCP.2018.19.8.2131

    Article  Google Scholar 

  • Galiotte MP, Kohler P, Mussi G, Gattás GJ (2008) Assessment of occupational genotoxic risk among Brazilian hairdressers. Ann OccupHyg 52(7):645–651. https://doi.org/10.1093/annhyg/men037

    Article  CAS  Google Scholar 

  • Gan HF, Meng XS, Song CH, Li BX (2003) A survey on health effects in a human population exposed to permanent-waving solution containing thioglycolic acid. J Occup Health 45(6):400–404. https://doi.org/10.1539/joh.45.400

    Article  CAS  Google Scholar 

  • Hartmann A, Agurell E, Beevers C, Brendler-Schwaab S, Burlinson B, Clay P, Collins A, Smith A, Speit G, Thybaud V, Tice RR (2003) 4th International Comet Assay Workshop Recommendations for conducting the in vivo alkaline Comet assay. 4th International Conet Assay Workshop. Mutagenesis 18(1):45–51

    Article  CAS  Google Scholar 

  • Hayashi M (2023) “Statistical significance” and other important considerations in genotoxicity safety testing. Mutat Res Genet Toxicol Environ Mutagen 888:503627

    Article  CAS  Google Scholar 

  • Karim M, Klein EJ, Nohria A, Taiwo D, Adotama P, Cohen D, Shapiro J, Milam E, Lo Sicco K (2023) Potential for allergic contact dermatitis in popular hair care practices and ingredients. Dermatitis. https://doi.org/10.1089/derm.2023.0045

    Article  Google Scholar 

  • Kirkland DJ, Honeycombe JR, Lawler SD, Venitt S, Crofton-Sleigh C (1981) Sister-chromatid exchanges before and after hair dyeing. Mutat Res 90(3):279–286. https://doi.org/10.1016/0165-1218(81)90008-2

    Article  CAS  Google Scholar 

  • Lauriola MM, Corazza M (2023) Dermato-allergological risks in beauty operators. Ital J Dermatol Venerol 158(3):243–248

    Google Scholar 

  • Li H, Åkerman G, Lidén C, Alhamdow A, Wojdacz TK, Broberg K, Albin M (2016) Alterations of telomere length and DNA methylation in hairdressers: a cross-sectional study. Environ Mol Mutagen 57(2):159–167. https://doi.org/10.1002/em.21991

    Article  CAS  Google Scholar 

  • Liljedahl ER, Wahlberg K, Lidén C, Albin M, Broberg K (2019) Genetic variants of filaggrin are associated with occupational dermal exposure and blood DNA alterations in hairdressers. Sci Total Environ 653:45–54. https://doi.org/10.1016/j.scitotenv.2018.10.328

    Article  CAS  Google Scholar 

  • Madnani N, Khan K (2013) Hair cosmetics. Indian J Dermatol Venereol Leprol 79(5):654–667

    Article  Google Scholar 

  • Malacarne IT, Takeshita WM, de Souza DV, Dos Anjos RB, de Barros VM, Renno ACM, Salvadori DMF, Ribeiro DA (2022) Is micronucleus assay in oral exfoliated cells a useful biomarker for biomonitoring populations exposed to pesticides? A systematic review with meta-analysis. Environ SciPollut Res Int 43:64392–64403

    Article  Google Scholar 

  • Muñoz X, Cruz MJ, Orriols R, Torres F, Espuga M, Morell F (2004) Validation of specific inhalation challenge for the diagnosis of occupational asthma due to persulphate salts. Occup Environ Med 61(10):861–816

    Article  Google Scholar 

  • Nersesyan A, Kundi M, Fenech M, Stopper H, da Silva J, Bolognesi C, Mišík M, Knasmueller S (2022) Recommendations and quality criteria for micronucleus studies with humans. Mutat Res Rev Mutat Res 789:108410

    Article  CAS  Google Scholar 

  • Rickes LN, Alvarengo MC, Souza TM, Garcias GL, Martino-Roth MG (2010) Increased micronucleus frequency in exfoliated cells of the buccal mucosa in hairdressers. Genet Mol Res 9(3):1921–1928. https://doi.org/10.4238/vol9-3gmr941

    Article  CAS  Google Scholar 

  • Sardaş S, Aygün N, Karakaya AE (1997) Genotoxicity studies on professional hair colorists exposed to oxidation hair dyes. Mutat Res 394(1–3):153–161. https://doi.org/10.1016/s1383-5718(97)00135-6

    Article  Google Scholar 

  • Turanitz K, Kovac R, Tuschl H, Pavlicek E (1983) Investigations on the effect of repeated hair dyeing on sister chromatid exchanges. Food Chem Toxicol 21(6):791–793. https://doi.org/10.1016/0278-6915(83)90214-4

    Article  CAS  Google Scholar 

  • Uter W, Johansen JD, Macan J, Symanzik C, John SM (2023) Diagnostics and prevention of occupational allergy in hairdressers. Curr Allergy Asthma Rep 23(5):267–275

    Article  CAS  Google Scholar 

  • Vlastos D, Ntinopoulos A (2011) Induction of micronuclei on Greek hairdressers occupationally exposed to chemical mixtures. Environ Toxicol 26(5):506–514. https://doi.org/10.1002/tox.20579

    Article  CAS  Google Scholar 

Download references

Funding

The authors acknowledge research grants received from CNPq (Conselho Nacional de DesenvolvimentoCientífico e Tecnológico, Grant Number #001) for productivity fellowship.

Author information

Authors and Affiliations

  1. Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Rua Silva Jardim, 136, Room 332, Vila Mathias, Santos– SP, 11050-020, Brazil

    Thiago Guedes Pinto, Ana Claudia Muniz Renno & Daniel Araki Ribeiro

  2. Department of Pathology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP, Sao Paulo, SP, Brazil

    Andrea Cristina de Moraes Malinverni

Authors
  1. Thiago Guedes Pinto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrea Cristina de Moraes Malinverni
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ana Claudia Muniz Renno
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Daniel Araki Ribeiro
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Study design: TGP and DAR. Data search: TGP and DAR. Data analysis: TGP, ACMM, ACMR and DAR. Writing the paper: TGP, ACMM, ACMR and DAR.

Corresponding author

Correspondence to Daniel Araki Ribeiro.

Ethics declarations

Conflict of interest

All authors declare there is no conflict of interest.

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Guedes Pinto, T., de Moraes Malinverni, A.C., Renno, A.C.M. et al. Do hairdressers comprise a high risk group for genotoxicity? A systematic review. Int Arch Occup Environ Health 96, 1077–1086 (2023). https://doi.org/10.1007/s00420-023-01999-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00420-023-01999-0

Keywords

Search

Navigation