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Baseline Cohort Profile of the Korean Chronic Cough Registry: A Multicenter, Prospective, Observational Study

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Abstract

Purpose

The Korean Chronic Cough Registry study was initiated to characterize patients with chronic cough (CC) and investigate their outcomes in real-world clinical practice. This report aims to describe the baseline cohort profile and study protocols.

Methods

This multicenter, prospective observational cohort study included newly referred CC patients and those already being treated for refractory or unexplained chronic cough (RUCC). Cough status was assessed using a visual analog scale, the Leicester Cough Questionnaire (LCQ), and the Cough Hypersensitivity Questionnaire (CHQ).

Results

A total of 610 patients (66.9% women; median age 59.0 years) were recruited from 18 centers, with 176 being RUCC patients (28.9%). The median age at CC onset was 50.1 years, and 94.4% had adult-onset CC (≥ 19 years). The median cough duration was 4 years. Compared to newly referred CC patients, RUCC patients had a longer cough duration (6.0 years vs. 3.0 years) but had fewer symptoms and signs suggesting asthma, rhinosinusitis, or gastroesophageal acid reflux disease. Subjects with RUCC had lower LCQ scores (10.3 ± 3.3 vs. 11.6 ± 3.6; P < 0.001) and higher CHQ scores (9.1 ± 3.9 vs. 8.4 ± 4.1; P = 0.024). There were no marked differences in the characteristics of cough between refractory chronic cough and unexplained chronic cough.

Conclusions

Chronic cough typically develops in adulthood, lasting for years. Cough severity and quality of life impairment indicate the presence of unmet clinical needs and insufficient cough control in real-world clinical practice. Longitudinal follow-up is warranted to investigate the natural history and treatment outcomes.

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Funding

The study was supported in part by a research grant from the Investigator-Initiated Studies Program of Merck Sharp & Dohme Corp. The sponsor had no role in the study design, data collection, analysis, result interpretation, publication decision, or manuscript preparation. The opinions expressed in this paper are entirely those of the authors.

Author information

Authors and Affiliations

  1. Department of Internal Medicine, School of Medicine, Pusan National University, Busan, Korea

    Eun-Jung Jo & Seung Eun Lee

  2. Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea

    Ji-Hyang Lee, Hyouk-Soo Kwon & Woo-Jung Song

  3. Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea

    Ha-Kyeong Won

  4. Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea

    Noeul Kang & Byung-Jae Lee

  5. Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea

    Sung-Yoon Kang

  6. Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea

    Seung Eun Lee

  7. Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea

    Ji-Ho Lee

  8. Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea

    Mi-Yeong Kim

  9. Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea

    Ji-Su Shim & Min-Hye Kim

  10. Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea

    Jin An

  11. Department of Internal Medicine, Gangneung Asan Hospital, Gangneung, Korea

    Youngsang Yoo

  12. Department of Internal Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Chung-Ang University College of Medicine, Seoul, Korea

    So-Young Park

  13. Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, University College of Medicine, Seoul, Korea

    Byung-Keun Kim

  14. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea

    Ji-Yong Moon & Sang-Heon Kim

  15. Department of Allergy and Clinical Immunology, School of Medicine, Kyungpook National University Chilgok Hospital, Kyungpook National University, Daegu, Korea

    Han-Ki Park

  16. Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea

    Sae-Hoon Kim & Yoon-Seok Chang

  17. Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea

    Sang-Hoon Kim

  18. Centre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK

    Surinder S. Birring

Authors
  1. Eun-Jung Jo
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Contributions

WJS is the full guarantor of this manuscript. WJS, BJL, and EJJ contributed to the study conception and design, and data interpretation. EJJ, JHL, HKW, NK, SYK, SEL, JHL, MYK, JSS, JA, YY, SYP, BKK, JYM, HKP, MHK, HSK, SHK, SHK, YSC, SHK, BJL and WJS have made contributions to the data acquisition. EJJ and WJS performed formal analysis and interpretation of data. EJJ and WJS drafted the first version of the manuscript. WJS, BJL, and SSB supervised and revised the manuscript. All authors approved this version of the manuscript for submission.

Corresponding authors

Correspondence to Byung-Jae Lee or Woo-Jung Song.

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Conflict of interests

SSB declares grants from Merck Sharp & Dohme Corp., consulting fees from Merck, Shionogi, Bayer, Nerre, Genentech/Roche and Bellus. WJS declares grants from Merck Sharp & Dohme Corp. and AstraZeneca, consulting fees from Merck, AstraZeneca, Shionogi and GSK, and lecture fees from Merck, AstraZeneca, GSK, Sanofi, and Novartis. Other authors declare that they have no competing interests.

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The authors declare no competing interests.

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Jo, EJ., Lee, JH., Won, HK. et al. Baseline Cohort Profile of the Korean Chronic Cough Registry: A Multicenter, Prospective, Observational Study. Lung 201, 477–488 (2023). https://doi.org/10.1007/s00408-023-00644-4

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