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Hospitalization Among Patients with Sarcoidosis: A Population-Based Cohort Study 1987–2015

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Abstract

Purpose

There is little information about healthcare utilization for sarcoidosis. This study examined need for hospitalization as a measure of healthcare burden in this disease.

Methods

A cohort of Olmsted County, Minnesota residents diagnosed with sarcoidosis between January 1, 1976 and December 31, 2013 was identified using the resources of the Rochester Epidemiology Project. Diagnosis was made based on individual medical record review. For each sarcoidosis subject, one sex- and age-matched comparator without sarcoidosis was randomly selected from the same population. Data on hospitalizations were retrieved electronically from billing data of the Mayo Clinic, the Olmsted Medical Center, and their affiliated hospitals. These data were available from 1987 to 2015. Subjects who died or emigrated from Olmsted County prior to 1987 were excluded.

Results

332 incident cases of sarcoidosis and 342 comparators were included. Hospitalization rates were significantly higher among patients with sarcoidosis than comparators [rate ratio (RR) 1.37; 95% confidence interval (CI) 1.24–1.52]. Analysis based on sex revealed a significantly increased rate among females (RR 1.60; 95% CI 1.40–1.82) but not among males (RR 1.06; 95% CI 0.91–1.25). The overall age- and sex-adjusted rates of hospitalization were stable from 1987 to 2015 for both cases and comparators. The average length of stay was similar (4.6 and 4.4 days for sarcoidosis and non-sarcoidosis hospitalizations, respectively, p = 0.87).

Conclusion

In this population, patients with sarcoidosis had a significantly higher rate of hospitalization than patients without sarcoidosis, driven by higher rates in females.

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Funding

This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health under Award Number R01AG034676, and CTSA Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, 200 First Avenue SW, Rochester, MN, 55905, USA

    Patompong Ungprasert, Cynthia S. Crowson & Eric L. Matteson

  2. Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand

    Patompong Ungprasert

  3. Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA

    Cynthia S. Crowson & Sara J. Achenbach

  4. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA

    Eva M. Carmona

  5. Division of Epidemiology, Department of Health Science Research, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA

    Eric L. Matteson

Authors
  1. Patompong Ungprasert
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  2. Cynthia S. Crowson
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  3. Sara J. Achenbach
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  4. Eva M. Carmona
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  5. Eric L. Matteson
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Corresponding author

Correspondence to Patompong Ungprasert.

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Conflict of interest

The authors have no financial or non-financial potential conflicts of interest to declare. Dr. Carmona is a CO-I in a registry for patients with sarcoidosis-associated pulmonary hypertension. The study is funded by Gilead.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Ungprasert, P., Crowson, C.S., Achenbach, S.J. et al. Hospitalization Among Patients with Sarcoidosis: A Population-Based Cohort Study 1987–2015. Lung 195, 411–418 (2017). https://doi.org/10.1007/s00408-017-0012-7

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  • DOI: https://doi.org/10.1007/s00408-017-0012-7

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