Abstract
Purpose
The influence of ethnicity on epidemiology and clinical manifestations of sarcoidosis is well recognized. However, data on the role of sex are limited.
Methods
The current study utilized the resource of the Rochester Epidemiology Project to identify all residents of Olmsted County, Minnesota, United States, with new diagnosis of sarcoidosis from 1976 to 2013. Diagnosis was verified by medical record and histopathological report review.
Results
345 incident cases of sarcoidosis were identified: 174 (50 %) were female and 171 (50 %) were male. The age at diagnosis was significantly higher among females than males (48.3 vs. 42.8 years; p < 0.001). Intra-thoracic disease was seen in the great majority of patients (98 % among females and 96 % among males; p = 0.50). However, pulmonary symptoms were significantly more frequent among males than females (51 vs. 36 %; p = 0.006). The frequency of individual extra-thoracic organ involvement was not significantly different between females and males except for cutaneous involvement and uveitis that were significantly more common among females (6 vs. 1 % for uveitis, p = 0.012 and 25 vs. 12 % for cutaneous involvement, p = 0.002). The frequency of elevate angiotensin-converting enzyme level and hypercalcemia was not significantly different between the two sexes.
Conclusions
Females tended to be older at the age they developed sarcoidosis, and had more uveitis and cutaneous involvement than males.
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References
Newman LS, Rose CS, Bresnitz EA et al (2004) A case control etiologic study of sarcoidosis: environmental and occupational risk factors. Am J Respir Crit Care Med 170:1324–1330
Rybicki BA, Major M, Popovich J Jr et al (1997) Racial differences in sarcoidosis incidence: a 5-year study in a health maintenance organization. Am J Epidemiol 145:234–241
Cozier YC, Berman JS, Palmer JR et al (2011) Sarcoidosis in black women in the United States: data from the black women’s health study. Chest 139:144–150
Morimoto T, Azuma A, Abe S et al (2008) Epidemiology of sarcoidosis in Japan. Eur Resp J 31:372–379
Westney GE, Judson MA (2006) Racial and ethnic disparities in sarcoidosis: from genetics to socioeconomics. Clin Chest Med 27:453–462
Ortona E, Pierdominici M, Maselli A et al (2016) Sex-based differences in autoimmune diseases. Ann Ist Super Sanita 52:205–212
Rocca WA, Yawn BP, St Sauver JL et al (2012) History of the rochester epidemiology project: half a century of medical records linkage in a U.S. population. Mayo Clin Proc 87:1202–1213
Costabel U, Hunninghake GW (1999) ATS/ERS/WASOG statement on sarcoidosis. Sarcoidosis statement committee. American Thoracic Society. European Respiratory Society. World association for sarcoidosis and other granulomatous disorders. Eur Respir J 14:735–737
Birnbaum AD, Rifkin LM (2014) Sarcoidosis: sex dependent variations in presentation and management. J Opthalmol 2014:236905
Brito-Zeron P, Sellares J, Bosch X et al (2016) Epidemiologic patterns of disease expression in sarcoidosis: age, gender and ethnicity-related differences. Clin Exp Rheumatol 34:380–388
Judson MA, Boan AD, Lackland DT (2012) The clinical course of sarcoidosis: presentation, diagnosis, and treatment in a large white and black cohort in the United States. Sarcoidosis Vasc Diffus Lung Dis 29:119–127
Birnbaum AD, Oh FS, Ckakrabarti A et al (2011) Clinical features and diagnostic evaluation of biopsy-proven ocular sarcodiosis. Arch Ophthalmol 129:409–413
Yanardag H, Nuri Pamuk O, Karayel T (2003) Cutaneous involvement in sarcoidosis: analysis of the features in 170 patients. Respir Med 97:978–982
Acknowledgment
This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health under Award Number R01AG034676, and CTSA Grant Number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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We do not have any financial or non-financial potential conflicts of interest.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Ungprasert, P., Crowson, C.S. & Matteson, E.L. Influence of Gender on Epidemiology and Clinical Manifestations of Sarcoidosis: A Population-Based Retrospective Cohort Study 1976–2013. Lung 195, 87–91 (2017). https://doi.org/10.1007/s00408-016-9952-6
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DOI: https://doi.org/10.1007/s00408-016-9952-6