Abstract
Background
Exercise-induced bronchoconstriction (EIB) has not been well studied in cystic fibrosis (CF), and eucapnic voluntary hyperventilation (EVH) testing has not been used as an objective assessment of EIB in CF to date.
Methods
A prospective cohort pilot study was completed where standard EVH testing was completed by 10 CF patients with forced expiratory volume in 1 s (FEV1) ≥70 % of predicted. All patients also completed a cardiopulmonary exercise test (CPET) with pre- and post-CPET spirometry as a comparative method of detecting EIB.
Results
No adverse events occurred with EVH testing. A total of 20 % (2/10) patients were diagnosed with EIB by means of EVH. Both patients had clinical symptoms consistent with EIB. No patient had a CPET-based exercise challenge consistent with EIB.
Conclusions
EVH testing was safe and effective in the objective assessment for EIB in patients with CF who had well-preserved lung function. It may be a more sensitive method of detecting EIB then exercise challenge.
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Acknowledgments
This study was supported by the Cystic Fibrosis Foundation (KIRKBY09AO), Nationwide Children’s Hospital Research Institute (232208), and The General Clinical Research Center at The Ohio State University, Grant M01-RR00034 from the National Center of Research Resources of the NIH.
Conflict of interest
Stephen Kirkby, Don Hayes, Jr., Jonathan Parsons, Clayton Wisely, Benjamin Kopp, and John Mastronarde have no conflict of interest to disclose. Karen McCoy declares that, as the CF Center Director, the funding is provided to her institution to participate in the research trials. There is no payment to him/her.She does not perceive any actual conflict of interest related to this Project.
Ethical standards
This study was approved by the institutional review boards of all participating centers, and informed consent was received from the parents of the participating patients.
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Clinical Trials Registration: This study was registered with ClinicalTrials.gov. Registration#: NCT00806455 Ohio State University. First received: December 9, 2008. Last updated: November 18, 2013. Last verified: November 2013.
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Kirkby, S.E., Hayes, D., Parsons, J.P. et al. Eucapnic Voluntary Hyperventilation to Detect Exercise-Induced Bronchoconstriction in Cystic Fibrosis. Lung 193, 733–738 (2015). https://doi.org/10.1007/s00408-015-9745-3
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DOI: https://doi.org/10.1007/s00408-015-9745-3