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Standardized pretreatment inflammatory laboratory markers and calculated ratios in patients with oral squamous cell carcinoma

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Abstract

Analyzing the inflammatory microenvironment has become an important issue in the management of oral squamous cell carcinoma (OSCC). Pretreatment C-reactive protein (CRP) levels, leucocytes, monocytes, lymphocytes, neutrophils, basophils, eosinophils, platelets, neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) derived from the peripheral blood were analyzed. Receiver operating characteristic (ROC) curves determined a cut-off value for each parameter in 146 patients with OSCC compared with 93 controls and the results were associated with clinicopathological characteristics. CRP expression of tumors was measured by immunohistochemistry. ROC analysis determined cut-off values for CRP levels, leucocytes, monocytes, lymphocytes, neutrophils, NLR, dNLR, LMR, PLR and showed significant differences between the OSCC and control group. Compared with single laboratory tests calculated ratios were superior in measuring sensitivity and specificity of OSCC disease. NLR was significant directly associated and correlated with PLR. LMR was significant inversely associated and correlated with NLR and PLR. Immunohistochemical analysis did not show CRP expression of OSCCs. This study highlights the first analysis for cut-off values of pretreatment single laboratory tests and calculated ratios, which are strongly needed for a follow-up of cancer patients. Additionally, the calculated baselines can be used as a goal for successful immunotherapies in the future. The links between NLR, LMR, and PLR might be helpful for the clinical course (monitoring) of cancer patients and have been first described for OSCC in this study. Taken together, analyzing these data provides an additional practical guideline of further postoperative OSCC management.

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Abbreviations

OSCC:

Oral squamous cell carcinoma

CP:

Clinicopathological parameters

CRP:

C-reactive protein

WBCs:

White blood cells

ROC:

Receiver operating characteristic

NLR:

Neutrophil-to-lymphocyte ratio

dNLR:

Derived NLR

LMR:

Lymphocyte-to-monocyte ratio

PLR:

Platelet-to-lymphocyte ratio

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Acknowledgments

The authors thank the assistance of Dr. Julia Grimm for her technical support.

Author information

Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, University Hospital Tuebingen, Osianderstrasse 2-8, 72076, Tuebingen, Germany

    Martin Grimm, Johan Rieth, Sebastian Hoefert, Michael Krimmel, Sven Rieth, Susanne Kluba, Adelheid Munz & Siegmar Reinert

  2. Cancer Research Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Peter Teriete

  3. Department of Pathology, University Hospital Tuebingen, Liebermeisterstrasse 8, 72076, Tuebingen, Germany

    Thorsten Biegner

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  1. Martin Grimm
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Corresponding author

Correspondence to Martin Grimm.

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Written informed consent to participate was obtained from all patients (Ethics Committee Tuebingen, Germany, approval number: 562-2013BO2).

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The authors declare that they have no conflict of interest.

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Grimm, M., Rieth, J., Hoefert, S. et al. Standardized pretreatment inflammatory laboratory markers and calculated ratios in patients with oral squamous cell carcinoma. Eur Arch Otorhinolaryngol 273, 3371–3384 (2016). https://doi.org/10.1007/s00405-016-3950-4

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