Skip to main content

Advertisement

SpringerLink
Log in

Acetazolamide in vestibular migraine prophylaxis: a retrospective study

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

The aim of this study is to check the efficacy of acetazolamide in the prophylaxis of vestibular migraine (VM). Treatment options in VM are mainly based on migraine guidelines. We tried to assess the efficacy of acetazolamide in these patients depending on clinical similarities with episodic ataxia type 2 and familial hemiplegic migraine responding to the drug. This is a retrospective cohort study. Among 50 patients with VM and prescribed acetazolamide 500 mg/day, 39 patients were studied as five had been lost on follow-up and six had stopped taking the drug due to side effects. Vertigo and headache frequency determined by number of attacks per month, and the severity determined by visual analog scales measured in centimeters from 0 to 10 were collected from the records. Initial reported figures for frequency and severity were compared with the results gathered after 3 months of treatment. The results were compared. Acetazolamide was effective in reducing both the frequency and severity of vertigo and headache attacks and this effect was more prominent for vertigo frequency and severity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Kayan A, Hood JD (1984) Neuro-otological manifestations of migraine. Brain 107:1123–1142

    Article  PubMed  Google Scholar 

  2. Cutrer FM, Baloh RW (1992) Migraine-associated dizziness. Headache 32:300–304

    Article  CAS  PubMed  Google Scholar 

  3. Cass SP, Furman JM, Ankerstjerne K, Balaban C, Yetişer S, Aydogan B (1997) Migraine-related vestibulopathy. Ann Otol Rhinol Laryngol 106:182–189

    Article  CAS  PubMed  Google Scholar 

  4. Dieterich M, Brandt T (1999) Episodic vertigo related to migraine. J Neurol 246:883–892

    Article  CAS  PubMed  Google Scholar 

  5. Neuhauser H, Leopold M, von Brevern M, Arnold G, Lempert T (2001) The interrelations of migraine, vertigo and migrainous vertigo. Neurology 56:436–441

    Article  CAS  PubMed  Google Scholar 

  6. Reploeg MD, Goebel JA (2002) Migraine-associated dizziness: patient characteristics and management options. Otol Neurotol 23:364–371

    Article  PubMed  Google Scholar 

  7. Lempert T, Olesen J, Furman J, Waterston J, Seemungal B, Carey J, Bisdorff A, Versino M, Evers S, Newman-Toker D (2012) Vestibular migraine: diagnostic criteria. J Vest Res 22:167–172

    Google Scholar 

  8. International Headache Society Classification Subcommittee (2013) The International Classification of Headache disorders, 3rd edition (beta version). Cephalalgia 33:629–808

    Article  Google Scholar 

  9. Neuhauser H, Radtke A, von Brevern M, Feldmann M, Lezius F, Ziese T, Lempert T (2006) Migrainous vertigo: prevalence and impact on quality of life. Neurology 67:1028–1033

    Article  CAS  PubMed  Google Scholar 

  10. Neff BA, Staab JP, Eggers SD, Carlson ML, Schmitt WR, Van Abel KM, Worthington DK, Beatty CW, Driscoll CL, Shepard NT (2012) Auditory and vestibular symptoms and chronic subjective dizziness in patients with Meniere’s disease, vestibular migraine and Meniere’s disease with concomitant vestibular migraine. Otol Neurotol 33:1235–1244

    Article  PubMed  Google Scholar 

  11. Radtke A, von Brevern M, Neuhauser H, Hottenrott T, Lempert T (2012) Vestibular migraine: long term follow-up of clinical symptoms and vestibulo-cochlear findings. Neurology 79:1607–1614

    Article  PubMed  Google Scholar 

  12. Celebisoy N, Gökçay F, Sirin H, Bıçak N (2008) Migrainous vertigo: clinical, oculographic and posturographic findings. Cephalalgia 28:72–77

    CAS  PubMed  Google Scholar 

  13. Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SM, Lamerdin JE (1996) Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 87:543–552

    Article  CAS  PubMed  Google Scholar 

  14. Von Brevern M, Ta N, Shankar A, Wieste A, Siegel A, Radtke A, Sander T, Escayg A (2006) Migrainous vertigo: mutation analysis of the candidate genes CACNA1A, ATP1A2, SCN1A, and CACNB4. Headache 46(1136–1):141

    Google Scholar 

  15. Kim JS, Yue Q, Jen JC, Nelson SF, Baloh RW (1998) Familial migraine with vertigo: no mutations found in CACNA1A. Am J Med Gen 79:148–151

    Article  CAS  Google Scholar 

  16. Lepcha A, Amalanathan S, Augustine AM, Tyagi AK, Balraj A (2014) Flunarizine in the prophylaxis of migrainous vertigo. Eur Arch Otorhinolaryngol 271:2931–2936

    Article  PubMed  Google Scholar 

  17. Bikhazi P, Jackson C, Ruckenstein MJ (1997) Efficacy of antimigrainous therapy in the treatment of migraine-associated dizziness. Am J Otol 18:350–354

    CAS  PubMed  Google Scholar 

  18. Maione A (2006) Migraine-related vertigo: diagnostic criteria and prophylactic treatment. Laryngoscope 116:1782–1786

    Article  PubMed  Google Scholar 

  19. Baier B, Winkenwerder E, Dieterich M (2009) “Vestibular migraine”: effects of prophylactic therapy with various drugs. A retrospective study. J Neurol 256:436–442

    Article  PubMed  Google Scholar 

  20. Bisdorff AR (2004) Treatment of migraine related vertigo with lamotrigine an observational study. Bull Soc Sci Med Grand Duche Luxemb 2:103–108

    PubMed  Google Scholar 

  21. Gode S, Celebisoy N, Kirazli T, Akyuz A, Bilgen C, Karapolat H, Sirin H, Gokcay F (2010) Clinical assessment of topiramate therapy in patients with migrainous vertigo. Headache 50:77–84

    Article  PubMed  Google Scholar 

  22. Taghdiri F, Togha M, Jahromi SR, Refaeian F (2014) Cinnarizine for the prophylaxis of migraine associated vertigo: a retrospective study. Springerplus 3:231–235

    Article  PubMed  PubMed Central  Google Scholar 

  23. Kohshi K, Konda N, Kinoshita Y, Tsuru E, Yokota A (1994) In situ arterial and brain tissue PCO2 responses to acetazolamide in cats. J Appl Physiol 76:2199–2203

    CAS  PubMed  Google Scholar 

  24. Aggarwal M, Kondeti B, McKenna R (2013) Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review. Expert Opin Ther Pat 23:717–724

    Article  CAS  PubMed  Google Scholar 

  25. De Simone R, Marano E, Di Stasio E, Bonuso S, Fiorillo C, Bonavita V (2005) Acetazolamide efficacy and tolerability in migraine with aura: a pilot study. Headache 45:385–386

    Article  PubMed  Google Scholar 

  26. Robbins MS, Lipton RB, Laureta EC, Grosberg BM (2009) CACNA1A nonsense mutation is associated with basilar-type migraine and episodic ataxia type 2. Headache 49:1042–1046

    Article  PubMed  Google Scholar 

  27. Tricarico D, Barbieri MG, Conte Camerino D (2000) Acetazolamide opens the muscular KCa2+ channel: a novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis. Ann Neurol 48:304–312

    Article  CAS  PubMed  Google Scholar 

  28. Omata T, Takanashi J, Wada T, Arai H, Tanabe Y (2011) Genetic diagnosis and acetazolamide treatment of familial hemiplegic migraine. Brain Dev 33:332–334

    Article  PubMed  Google Scholar 

  29. Shirai T, Meyer JS, Akiyama H, Mortel KF, Wills PM (1996) Acetazolamide testing of cerebral vasodilator capacity provokes ‘vascular’ but not tension headaches. Headache 36:589–594

    Article  CAS  PubMed  Google Scholar 

  30. Evers S, Afra J, Frese A, Goadsby PJ, Linde M, May A, Sandor PS (2009) EFNS guideline on the drug treatment of migraine-revised report of an EFNS task force. Eur J Neurol 16:968–981

    Article  CAS  PubMed  Google Scholar 

  31. Loder E, Burch R, Rizzoli P (2012) The 2012 AHS/AAN guidelines for prevention of episodic migraine: a summary and comparison with other recent clinical practice guidelines. Headache 52:930–945

    Article  PubMed  Google Scholar 

  32. Linde M, Mulleners WM, Chronicle EP, McCrory DC (2013) Antiepileptics other than gabapentin, pregabalin, topiramate, and valproate for the prophylaxis of episodic migraine in adults (review). Cochrane Database Syst Rev 6:1–58

    Google Scholar 

  33. Baloh RW, Foster CA, Yue Q, Nelson SF (1996) Familial migraine with vertigo and essential tremor. Neurology 46:458–460

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Ege University Medical School, Bornova, İzmir, 35100, Turkey

    Neşe Çelebisoy & Figen Gökçay

  2. Department of Otorhinolaryngology, Head and Neck Surgery, Ege University Medical School, Bornova, İzmir, 35100, Turkey

    Ceyda Karahan, Cem Bilgen & Tayfun Kirazlı

  3. Department of Physical Medicine and Rehabilitation, Ege University Medical School, Bornova, İzmir, 35100, Turkey

    Hale Karapolat

  4. Department of Biostatistics and Medical Informatics, Ege University Medical School, Bornova, İzmir, 35100, Turkey

    Timur Köse

Authors
  1. Neşe Çelebisoy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Figen Gökçay
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ceyda Karahan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Cem Bilgen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tayfun Kirazlı
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hale Karapolat
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Timur Köse
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Neşe Çelebisoy.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Çelebisoy, N., Gökçay, F., Karahan, C. et al. Acetazolamide in vestibular migraine prophylaxis: a retrospective study. Eur Arch Otorhinolaryngol 273, 2947–2951 (2016). https://doi.org/10.1007/s00405-015-3874-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-015-3874-4

Keywords

Search

Navigation