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Use of cidofovir in HPV patients with recurrent respiratory papillomatosis

  • Laryngology
  • Published:
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A Letter to the Editor to this article was published on 29 October 2014

Abstract

Recurrent respiratory papillomatosis is a viral-induced disease, associated with exophytic epithelial lesions affecting the upper airways. Problem of treatment is the high recurrence of papilloma growth after surgical removal; therefore, adjuvant therapy schemes have been established. We used cidofovir, 7.5 mg/ml, in adjuvant therapy in the past years. Out of 31 adult patients treated with the drug, 26 (83.9 %) are at the moment in complete response. 19 (73 % of pts with CR) of those 26 patients were cured with a number of injections between 1 and 4 (mean 2.5). We did not see any clinical manifestation of renal toxicity or neutropenia (superinfection) necessitating a blood test. Six patients presented dysplasia during the treatment with the drug, while six patients had dysplasia prior to cidofovir injection. Due to recurrent nature of the disease and the high number of mechanical and laser surgeries required we treated one tracheal stenosis, two scarred larynx, and two glottic synechiaes. There is still an ongoing discussion within the European Laryngological Society about the effectiveness and possible side effects of this drug. Results show promising long-term effects of adjuvant use of cidofovir, without any relevant side effects.

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Conflict of interest

The authors declare no conflict of interest concerning funding sources, relevant patents, financial and business relationship to sponsors, companies related to the research, or the outcome of the studies in the manuscript.

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Authors and Affiliations

  1. Otorhinolaryngology Section, Department of Sensorial Organs, “Sapienza” University of Rome, Rome, Italy

    M. Grasso

  2. Department of Otorhinolaryngology, University Hospital of Louvain de Mont-Godinne, Yvoir, Belgium

    M. Remacle, V. Bachy, S. Van Der Vorst & G. Lawson

  3. via San Silverio 15, 00165, Rome, Italy

    M. Grasso

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  1. M. Grasso
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  2. M. Remacle
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Correspondence to M. Grasso.

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Grasso, M., Remacle, M., Bachy, V. et al. Use of cidofovir in HPV patients with recurrent respiratory papillomatosis. Eur Arch Otorhinolaryngol 271, 2983–2990 (2014). https://doi.org/10.1007/s00405-014-3055-x

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  • DOI: https://doi.org/10.1007/s00405-014-3055-x

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