Abstract
Recurrent respiratory papillomatosis (RRP) primarily caused by human papillomas virus is a rare and benign neoplasm, primarily involving the epithelium mucosae of the respiratory tract. RRP may occur anywhere in the respiratory tract with a predilection to the laryngeal area and may potentially threaten life. Because of the absence of specific clinical manifestations, the diagnosis of this disease is easily delayed. The high awareness of RRP and performing endoscopy as soon as possible in suspected patients are the prerequisites for early diagnosis. Surgical removal on endoscope is still a fundamental treatment. Adjuvant treatment is required only in some patients. Because of the potential of malignant transformation and recurrence, careful follow-up for RRP is required for early detection and treatment.
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Chhetri DK, Shapiro NL (2003) A scheduled protocol for the treatment of juvenile recurrent respiratory papillomatosis with intralesional cidofovir. Arch Otolaryngol Head Neck Surg 129:1081–1085
Bishai D, Kashima H, Shah K (2000) The cost of juvenile-onset recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg 126:935–939
Steinbrook R (2006) The potential of human papillomavirus vaccines. N Engl J Med 354:1109–1112
Ribeiro KM, Alvez JM, Pignatari SS et al (2006) Detection of human papilloma virus in the tonsils of children undergoing tonsillectomy. Braz J Infect Dis 10:165–168
Gissmann L, Wolnik L, Ikenberg H et al (1983) Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proc Natl Acad Sci USA 80:560–563
Silverberg MJ, Thorsen P, Lindeberg H et al (2003) Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosis. Obstet Gynecol 101:645–652
Kashima HK, Shah F, Lyles A et al (1992) A comparison of risk factors in juvenile-onset and adult-onset recurrent respiratory papillomatosis. Laryngoscope 102:9–13
Pignatari SS, Liriano RY, Avelino MA et al (2007) Gastroesophageal reflux in patients with recurrent laryngeal papillomatosis. Braz J Otorhinolaryngol 73:210–214
Tabrizi SN, Garland SM (1996) Is cryotherapy treating or infecting? Med J Aust 164:263
Garden JM, O’Banion MK, Bakus AD et al (2002) Viral disease transmitted by laser-generated plume (aerosol). Arch Dermatol 138:1303–1307
Carvalho CM, Huot L, Charlois AL et al (2009) Prognostic factors of recurrent respiratory papillomatosis from a registry of 72 patients. Acta Otolaryngol 129:462–470
Soldatski IL, Onufrieva EK, Steklov AM et al (2005) Tracheal, bronchial, and pulmonary papillomatosis in children. Laryngoscope 115:1848–1854
Shibuya H, Kutomi T, Kujime K et al (2008) An adult case of multiple squamous papillomas of the trachea associated with human papilloma virus type 6. Inter Med 47:1535–1538
DeVoti JA, Rosenthal DW, Wu R et al (2008) Immune dysregulation and tumor-associated gene changes in recurrent respiratory papillomatosis: a paired microarray analysis. Mol Med 14:608–617
Wu R, Abramson AL, Shikowitz MJ et al (2005) Epidermal growth factor-induced cyclooxygenase-2 expression is mediated through phosphatidylinositol-3 kinase, not mitogen-activated protein/extracellular signal-regulated kinase kinase, in recurrent respiratory papillomas. Clin Cancer Res 11(17):6155–6161
Scurry WC Jr, McGinn JD (2008) Recurrent respiratory papillomatosis in pregnancy: a case of emergent airway management. Ear Nose Throat J 87:E8–E11
Rady PL, Schnadig VJ, Weiss RL et al (1998) Malignant transformation of recurrent respiratory papillomatosis associated with integrated human papillomavirus type 11 DNA and mutation of p53. Laryngoscope 108:735–740
Gerein V, Rastorguev E, Gerein J et al (2004) 2′, 5′-Oligoadenylate synthetase activity analysis and human papilloma virus typing as prognostic factors in patients with recurrent respiratory papillomatosis. J Laryngol Otol 118:750–756
Blumin JH, Handler EB, Simpson CB et al (2009) Dysplasia in adults with recurrent respiratory papillomatosis: incidence and risk factors. Ann Otol Rhinol Laryngol 118:481–485
Lee LA, Cheng AJ, Fang TJ et al (2008) High incidence of malignant transformation of laryngeal papilloma in Taiwan. Laryngoscope 118:50–55
Leman JA, Benton EC (2000) Verrucas. Guidelines for management. Am J Clin Dermatol 1:143–149
Pignatari S, Smith EM, Gray SD et al (1992) Detection of human papillomavirus infection in diseased and nondiseased sites of the respiratory tract in recurrent respiratory papillomatosis patients by DNA hybridization. Ann Otol Rhinol Laryngol 101:408–412
Fox PA, Tung MY (2005) Human papillomavirus: burden of illness and treatment cost considerations. Am J Clin Dermatol 6:365–381
Perkins JA, Inglis AF Jr, Richardson MA (1998) Iatrogenic airway stenosis with recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg 124:281–287
Ulualp SO, Ryan MW, Wright ST (2007) Microdebrider removal of tracheal papilloma via tracheostomy in the child with an obliterated larynx. J Laryngol Otol 121:1070–1072
Thorne MC, Zur KB (2009) Transoral trans-stomal microdebrider excision of tracheal papillomatosis. Laryngoscope 119:964–966
Derkay CS (1995) Task force on recurrent respiratory papillomas. A preliminary report. Arch Otolaryngol Head Neck Surg 121:1386–1391
Kimberlin DW (2004) Current status of antiviral therapy for juvenile-onset recurrent respiratory papillomatosis. Antiviral Res 63:141–151
Bielecki I, Mniszek J, Cofała M (2009) Intralesional injection of cidofovir for recurrent respiratory papillomatosis in children. Int J Pediatr Otorhinolaryngol 73:681–684
Donne AJ, Rothera MP, Homer JJ (2008) Scientific and clinical aspects of the use of cidofovir in recurrent respiratory papillomatosis. Int J Pediatr Otorhinolaryngol 72:939–944
McMurray JS, Connor N, Ford CN (2008) Cidofovir efficacy in recurrent respiratory papillomatosis: a randomized, double-blind, placebo-controlled study. Ann Otol Rhinol Laryngol 117:477–483
Broekema FI, Dikkers FG (2008) Side-effects of cidofovir in the treatment of recurrent respiratory papillomatosis. Eur Arch Otorhinolaryngol 265:871–879
Lott DG, Krakovitz PR (2009) Squamous cell carcinoma associated with intralesional injection of cidofovir for recurrent respiratory papillomatosis. Laryngoscope 119:567–570
Kashima H, Leventhal B, Clark K et al (1988) Interferon alfa-n1 (Wellferon) in juvenile onset recurrent respiratory papillomatosis: results of a randomized study in twelve collaborative institutions. Laryngoscope 98:334–340
Gerein V, Rastorguev E, Gerein J et al (2005) Use of interferon-alpha in recurrent respiratory papillomatosis: 20-year follow-up. Ann Otol Rhinol Laryngol 114:463–471
Villa LL, Costa RL, Petta CA et al (2005) Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial. Lancet Oncol 6:271–278
Govan VA (2008) A novel vaccine for cervical cancer: quadrivalent human papillomavirus (types 6, 11, 16 and 18) recombinant vaccine (Gardasil). Ther Clin Risk Manag 4:65–70
Freed GL, Derkay CS (2006) Prevention of recurrent respiratory papillomatosis: role of HPV vaccination. Int J Pediatr Otorhinolaryngol 70:1799–1803
Chesson HW, Forhan SE, Gottlieb SL et al (2008) The potential health and economic benefits of preventing recurrent respiratory papillomatosis through quadrivalent human papillomavirus vaccination. Vaccine 26:4513–4518
Vandepapeliere P, Barrasso R, Meijer CJ et al (2005) Randomized controlled trial of an adjuvanted human papillomavirus (HPV) type 6 L2E7 vaccine: infection of external anogenital warts with multiple HPV types and failure of therapeutic vaccination. J Infect Dis 192:2099–2107
Giuliano AR, Tortolero-Luna G, Ferrer E et al (2008) Epidemiology of human papillomavirus infection in men, cancers other than cervical and benign conditions. Vaccine 26(Suppl 10):K17–K28
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Xue, Q., Wang, H. & Wang, J. Recurrent respiratory papillomatosis: an overview. Eur J Clin Microbiol Infect Dis 29, 1051–1054 (2010). https://doi.org/10.1007/s10096-010-0963-6
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DOI: https://doi.org/10.1007/s10096-010-0963-6