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Green tea, black tea consumption and risk of endometrial cancer: a systematic review and meta-analysis

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Several studies have assessed the association between green and black tea consumption and the risk of endometrial cancer (EC) and have yielded inconsistent results.

Objective

The purpose of this meta-analysis is to systematically analyze the effect of green tea and black tea on EC risk.

Methods

PubMed, Embase, Cochrane Library and China Biological Medicine Database were searched through February 2, 2015 to identify studies that met pre-stated inclusion criteria. Overall relative risk (RR) was estimated based on the highest and lowest levels of green/black tea consumption. Dose–response relationships were evaluated with the data from categories of green/black tea intake in each study.

Results

For green tea, the summary RR indicated that the highest green tea consumption was associated with a reduced risk of EC (RR 0.78, 95 % CI 0.66–0.92). Furthermore, an increase in green tea consumption of one cup per day was associated with an 11 % decreased risk of developing EC. (RR 0.89, 95 % CI 0.84–0.94). For black tea, no statistically significant association was observed in the meta-analysis (highest versus non/lowest, RR 0.99, 95 % CI 0.79–1.23; increment of one cup/day, RR 0.99, 95 % CI 0.94–1.03). The power of the estimate of green tea and black tea with risk of EC was 84.33 and 5.07 %, respectively. The quality of evidence for the association between green and black tea with EC risk was moderate and very low, respectively.

Conclusions

The results from this meta-analysis indicate that green tea, but not black tea, may be related to a reduction of EC risk. Large population-based randomized controlled trials and large prospective cohort studies are required to obtain a definitive conclusion and determine the mechanisms underlying this association.

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Acknowledgments

This work was supported by Instructional science and technology Program of Changde City (2014ZD11), NSFC (Natural Science Foundation of China) (81360351).

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    Authors and Affiliations

    1. Department of Science and Education, First People’s Hospital of Changde City, No. 818, Renming road, Changde, 415003, Hunan, China

      Quan Zhou

    2. Department of Oncology, First People’s Hospital of Changde City, No. 818, Renming road, Changde, 415003, Hunan, China

      Hui Li & Tao Wu

    3. Department of Oncology, Affiliated Hospital of Zunyi Medical University, Zunyi Medical University, No. 149, Dalian road, Zunyi, 563000, Guizhou, China

      Jian-Guo Zhou & Hu Ma

    4. Department of Acupuncture and Moxibustion, Liaoning University of Traditional Chinese Medicine, No. 79, Chongshan road, Shenyang, 110032, Liaoning, China

      Yuan Ma

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    Correspondence to Tao Wu or Hu Ma.

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    Q. Zhou, H. Li and J.-G. Zhou have contributed equally to this work.

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    Appendix 1: Meta-analysis of Observational Studies in Epidemiology (MOOSE) Checklist (DOC 49 kb)

    Appendix2: SAS code for power calculations (DOC 24 kb)

    404_2015_3811_MOESM3_ESM.doc

    Supplementary Appendix3: Supplemental characteristics of studies in the meta-analysis of tea intake and EC risk (DOC 38 kb)

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    Zhou, Q., Li, H., Zhou, JG. et al. Green tea, black tea consumption and risk of endometrial cancer: a systematic review and meta-analysis. Arch Gynecol Obstet 293, 143–155 (2016). https://doi.org/10.1007/s00404-015-3811-1

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