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Bone marrow edema of the hip: a narrative review

  • Hip Arthroplasty
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Abstract

Bone marrow edema (BME) of the hip is a radiological-clinical condition with symptoms ranging from asymptomatic to severe, and it is characterized by increased interstitial fluid within the bone marrow, usually at the femur. Depending on the etiology it can be classified as primary or secondary. The primary cause of BME is unknown, while the secondary forms include traumatic, degenerative, inflammatory, vascular, infectious, metabolic, iatrogenic, and neoplastic etiologies. BME could be classified as reversible or progressive. Reversible forms include transient BME syndrome and regional migratory BME syndrome. Progressive forms include avascular necrosis of the femoral head (AVNH), subchondral insufficiency fracture, and hip degenerative arthritis. The diagnosis can be difficult, because at the beginning, the outbreak of hip pain, typically acute and disabling without any prior trauma or exceptional physical activity, is poorly supported by radiographic findings. MRI is the gold standard, and it shows an area of intermediate signal on T1-weighted MRI scans and a high signal on T2-weighted scans, usually lacking sharps margins. In the reversible form, BME is typically self-limiting, and it can be managed conservatively by means of pharmacological and physical therapy. Surgery is generally required for progressive forms in patients who failed non-operative treatment, and it ranges from femoral head and neck core decompression to total hip arthroplasty.

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References

  1. Wilson AJ, Murphy WA, Hardy DC, Totty WG (1988) Transient osteoporosis: transient bone marrow edema? Radiology 167:757–760. https://doi.org/10.1148/radiology.167.3.3363136

    Article  CAS  PubMed  Google Scholar 

  2. Tarantino U, Greggi C, Cariati I et al (2022) Bone marrow edema: overview of etiology and treatment strategies. JBJS 104:189. https://doi.org/10.2106/JBJS.21.00300

    Article  Google Scholar 

  3. Vassalou EE, Spanakis K, Tsifountoudis IP, Karantanas AH (2019) MR imaging of the hip: an update on bone marrow edema. Semin Musculoskelet Radiol 23:276–288. https://doi.org/10.1055/s-0039-1677872

    Article  PubMed  Google Scholar 

  4. Starr AM, Wessely MA, Albastaki U et al (2008) Bone marrow edema: pathophysiology, differential diagnosis, and imaging. Acta Radiol 49:771–786. https://doi.org/10.1080/02841850802161023

    Article  CAS  PubMed  Google Scholar 

  5. Manara M, Varenna M (2014) A clinical overview of bone marrow edema. Reumatismo 66:184–196. https://doi.org/10.4081/reumatismo.2014.790

    Article  CAS  PubMed  Google Scholar 

  6. Patel S (2014) Primary bone marrow oedema syndromes. Rheumatology 53:785–792. https://doi.org/10.1093/rheumatology/ket324

    Article  PubMed  Google Scholar 

  7. Geith T, Stellwag A-C, Müller EP et al (2020) Is bone marrow edema syndrome a precursor of hip or knee osteonecrosis? Results of 49 patients and review of the literature. Diagn Interv Radiol 26:355–362. https://doi.org/10.5152/dir.2020.19188

    Article  PubMed  PubMed Central  Google Scholar 

  8. Foti G, Faccioli N, Silva R et al (2020) Bone marrow edema around the hip in non-traumatic pain: dual-energy CT vs MRI. Eur Radiol 30:4098–4106. https://doi.org/10.1007/s00330-020-06775-z

    Article  PubMed  Google Scholar 

  9. Hofmann S (2005) The painful bone marrow edema syndrome of the hip joint. Wien Klin Wochenschr 117:111–120. https://doi.org/10.1007/s00508-005-0322-2

    Article  PubMed  Google Scholar 

  10. Eriksen EF, Ringe JD (2012) Bone marrow lesions: a universal bone response to injury? Rheumatol Int 32:575–584. https://doi.org/10.1007/s00296-011-2141-2

    Article  CAS  PubMed  Google Scholar 

  11. Klontzas ME, Zibis AH, Vassalou EE, Karantanas AH (2017) MRI of the hip: current concepts on bone marrow oedema. Hip Int. https://doi.org/10.5301/hipint.5000527

    Article  PubMed  Google Scholar 

  12. Xu L, Hayashi D, Roemer FW et al (2012) Magnetic resonance imaging of subchondral bone marrow lesions in association with osteoarthritis. Semin Arthritis Rheum 42:105–118. https://doi.org/10.1016/j.semarthrit.2012.03.009

    Article  PubMed  PubMed Central  Google Scholar 

  13. Aaron RK, Dyke JP, Ciombor DM et al (2007) Perfusion abnormalities in subchondral bone associated with marrow edema, osteoarthritis, and avascular necrosis. Ann N Y Acad Sci 1117:124–137. https://doi.org/10.1196/annals.1402.069

    Article  PubMed  Google Scholar 

  14. MRI findings of the shoulder and hip joint in patients with polymyalgia rheumatica | Modern Rheumatology | Oxford Academic. https://academic.oup.com/mr/article/25/5/761/6302943?login=false. Accessed 20 Dec 2022

  15. Varenna M, Crotti C (2018) Bisphosphonates in the treatment of complex regional pain syndrome: is bone the main player at early stage of the disease? Rheumatol Int 38:1959–1962. https://doi.org/10.1007/s00296-018-4101-6

    Article  CAS  PubMed  Google Scholar 

  16. Sax AJ, Halpern EJ, Zoga AC et al (2020) Predicting osteomyelitis in patients whose initial MRI demonstrated bone marrow edema without corresponding T1 signal marrow replacement. Skeletal Radiol 49:1239–1247. https://doi.org/10.1007/s00256-020-03396-x

    Article  PubMed  Google Scholar 

  17. Bierry G, Huang AJ, Chang CY et al (2012) MRI findings of treated bacterial septic arthritis. Skeletal Radiol 41:1509–1516. https://doi.org/10.1007/s00256-012-1397-2

    Article  PubMed  Google Scholar 

  18. A case of probable hydroxyapatite deposition disease (HADD) of the Hip. https://www.jstage.jst.go.jp/article/mrms/3/3/3_3_141/_article. Accessed 20 Dec 2022

  19. Chua E, Shah D (2022) Hydroxyapatite crystal deposition disease around the hip: a rare cause of piriformis syndrome and ischiofemoral impingement. BJR Case Rep 7:20210075. https://doi.org/10.1259/bjrcr.20210075

    Article  PubMed  PubMed Central  Google Scholar 

  20. Weaver JS, Omar I, Mar W et al (2022) Magnetic resonance imaging of rheumatological diseases. Pol J Radiol 87:e93–e112. https://doi.org/10.5114/pjr.2022.113390

    Article  PubMed  PubMed Central  Google Scholar 

  21. James SLJ, Panicek DM, Davies AM (2008) Bone marrow oedema associated with benign and malignant bone tumours. Eur J Radiol 67:11–21. https://doi.org/10.1016/j.ejrad.2008.01.052

    Article  CAS  PubMed  Google Scholar 

  22. Diaz-Ledezma C, Casaccia M, Parvizi J (2013) Reports of magnetic resonance images of the hip in patients with femoroacetabular impingement: is useful information provided to the orthopedic surgeon? Skeletal Radiol 42:335–340. https://doi.org/10.1007/s00256-012-1499-x

    Article  PubMed  Google Scholar 

  23. Transient osteoporosis of the hip, complete resolution after treatment with alendronate as observed by MRI description of eight cases and review of the literature | SpringerLink. https://link.springer.com/article/10.1007/s10067-012-2060-y. Accessed 20 Dec 2022

  24. Bashaireh KM, Aldarwish FM, Al-Omari AA et al (2020) Transient osteoporosis of the hip: risk and therapy. Open Access Rheumatol 12:1–8. https://doi.org/10.2147/OARRR.S236324

    Article  PubMed  PubMed Central  Google Scholar 

  25. Transient Osteoporosis of the Hip: State of the Art and Review of Literature. https://www.fortunejournals.com/articles/transient-osteoporosis-of-the-hip-state-of-the-art-and-review-of-literature.html. Accessed 20 Dec 2022

  26. Uzun M, Ayhan E, Beksac B, Karaman Ö (2013) Regional migratory osteoporosis and transient osteoporosis of the hip: are they all the same? Clin Rheumatol 32:919–923. https://doi.org/10.1007/s10067-013-2243-1

    Article  PubMed  Google Scholar 

  27. Cahir JG, Toms AP (2008) Regional migratory osteoporosis. Eur J Radiol 67:2–10. https://doi.org/10.1016/j.ejrad.2008.01.051

    Article  PubMed  Google Scholar 

  28. Zhao D, Zhang F, Wang B et al (2020) Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version). J Orthop Translat 21:100–110. https://doi.org/10.1016/j.jot.2019.12.004

    Article  PubMed  PubMed Central  Google Scholar 

  29. Hines JT, Jo W-L, Cui Q et al (2021) Osteonecrosis of the Femoral head: an updated review of ARCO on pathogenesis, staging and treatment. J Korean Med Sci 36:e177. https://doi.org/10.3346/jkms.2021.36.e177

    Article  PubMed  PubMed Central  Google Scholar 

  30. Shah KN, Racine J, Jones LC, Aaron RK (2015) Pathophysiology and risk factors for osteonecrosis. Curr Rev Musculoskelet Med 8:201–209. https://doi.org/10.1007/s12178-015-9277-8

    Article  PubMed  PubMed Central  Google Scholar 

  31. Lee G-C, Khoury V, Steinberg D et al (2014) How do radiologists evaluate osteonecrosis? Skeletal Radiol 43:607–614. https://doi.org/10.1007/s00256-013-1803-4

    Article  PubMed  Google Scholar 

  32. Sultan AA, Mohamed N, Samuel LT et al (2019) Classification systems of hip osteonecrosis: an updated review. Int Orthop 43:1089–1095. https://doi.org/10.1007/s00264-018-4018-4

    Article  PubMed  Google Scholar 

  33. George G, Lane JM (2022) Osteonecrosis of the femoral head. J Am Acad Orthop Surg Glob Res Rev 6(e21):00176. https://doi.org/10.5435/JAAOSGlobal-D-21-00176

    Article  Google Scholar 

  34. Chen M, Wang X, Takahashi E et al (2022) Current research on subchondral insufficiency fracture of the femoral head. Clin Orthop Surg 14:477–485. https://doi.org/10.4055/cios22175

    Article  PubMed  PubMed Central  Google Scholar 

  35. Yamamoto T (2012) Subchondral insufficiency fractures of the femoral head. Clin Orthop Surg 4:173–180. https://doi.org/10.4055/cios.2012.4.3.173

    Article  PubMed  PubMed Central  Google Scholar 

  36. Steele CE, Cochran G, Renninger C et al (2018) Femoral neck stress fractures: MRI risk factors for progression. J Bone Jt Surg Am 100:1496–1502. https://doi.org/10.2106/JBJS.17.01593

    Article  Google Scholar 

  37. Nishino T, Sugaya H, Kikuchi N et al (2021) Bilateral stress fracture of the femoral neck in association with simultaneously developing osteonecrosis of the femoral head: a case report. J Med Case Rep 15:607. https://doi.org/10.1186/s13256-021-03198-2

    Article  PubMed  PubMed Central  Google Scholar 

  38. Kasahara K, Kita N, Kawasaki T et al (2017) Bilateral femoral neck fractures resulting from pregnancy-associated osteoporosis showed bone marrow edema on magnetic resonance imaging. J Obstet Gynaecol Res 43:1067–1070. https://doi.org/10.1111/jog.13313

    Article  PubMed  PubMed Central  Google Scholar 

  39. Shabestari M, Vik J, Reseland JE, Eriksen EF (2016) Bone marrow lesions in hip osteoarthritis are characterized by increased bone turnover and enhanced angiogenesis. Osteoarthritis Cartilage 24:1745–1752. https://doi.org/10.1016/j.joca.2016.05.009

    Article  CAS  PubMed  Google Scholar 

  40. Taljanovic MS, Graham AR, Benjamin JB et al (2008) Bone marrow edema pattern in advanced hip osteoarthritis: quantitative assessment with magnetic resonance imaging and correlation with clinical examination, radiographic findings, and histopathology. Skeletal Radiol 37:423–431. https://doi.org/10.1007/s00256-008-0446-3

    Article  PubMed  Google Scholar 

  41. Mirghasemi SA, Trepman E, Sadeghi MS et al (2016) Bone marrow edema syndrome in the foot and ankle. Foot Ankle Int 37:1364–1373. https://doi.org/10.1177/1071100716664783

    Article  PubMed  Google Scholar 

  42. White TC, Davis DD, Cooper JS (2022) Dysbaric osteonecrosis. StatPearls Publishing, Treasure Island

    Google Scholar 

  43. Tarantino U, Greggi C, Cariati I et al (2021) Reviewing bone marrow edema in athletes: a difficult diagnostic and clinical approach. Medicina (Kaunas) 57:1143. https://doi.org/10.3390/medicina57111143

    Article  PubMed  Google Scholar 

  44. Choi H-R, Steinberg ME, Cheng EY (2015) Osteonecrosis of the femoral head: diagnosis and classification systems. Curr Rev Musculoskelet Med 8:210–220. https://doi.org/10.1007/s12178-015-9278-7

    Article  PubMed  PubMed Central  Google Scholar 

  45. Schapira D (1992) Transient osteoporosis of the hip. Semin Arthritis Rheum 22:98–105. https://doi.org/10.1016/0049-0172(92)90003-V

    Article  CAS  PubMed  Google Scholar 

  46. Szwedowski D, Nitek Ż, Walecki J (2014) Evaluation of transient osteoporosis of the hip in magnetic resonance imaging. Pol J Radiol 79:36–38. https://doi.org/10.12659/PJR.889827

    Article  PubMed  PubMed Central  Google Scholar 

  47. Hofmann S, Schneider W, Breitenseher M et al (2000) “Transient osteoporosis” as a special reversible form of femur head necrosis. Orthopade 29:411–419. https://doi.org/10.1007/s001320050462

    Article  CAS  PubMed  Google Scholar 

  48. Korompilias AV, Karantanas AH, Lykissas MG, Beris AE (2009) Bone marrow edema syndrome. Skeletal Radiol 38:425–436. https://doi.org/10.1007/s00256-008-0529-1

    Article  PubMed  Google Scholar 

  49. O’Hare A, Shortt C, Napier N, Eustace SJ (2006) Bone marrow edema: patterns and clinical implications. Semin Musculoskelet Radiol 10:249–257. https://doi.org/10.1055/s-2007-971996

    Article  PubMed  Google Scholar 

  50. Davis DD, Kane SM (2022) Bone marrow edema syndrome. StatPearls Publishing, Treasure Island

    Google Scholar 

  51. Son W, Park C, Jeong HS et al (2020) Bone marrow edema in non-traumatic hip: high accuracy of dual-energy CT with water-hydroxyapatite decomposition imaging. Eur Radiol 30:2191–2198. https://doi.org/10.1007/s00330-019-06519-8

    Article  CAS  PubMed  Google Scholar 

  52. Pache G, Krauss B, Strohm P et al (2010) Dual-energy CT virtual noncalcium technique: detecting posttraumatic bone marrow lesions–feasibility study. Radiology 256:617–624. https://doi.org/10.1148/radiol.10091230

    Article  PubMed  Google Scholar 

  53. An Y-S, Park S, Jung J-Y et al (2019) Clinical characteristics and role of whole-body bone scan in multifocal osteonecrosis. BMC Musculoskelet Disord 20:23. https://doi.org/10.1186/s12891-019-2401-y

    Article  PubMed  PubMed Central  Google Scholar 

  54. Pierce TP, Jauregui JJ, Cherian JJ et al (2015) Imaging evaluation of patients with osteonecrosis of the femoral head. Curr Rev Musculoskelet Med 8:221–227. https://doi.org/10.1007/s12178-015-9279-6

    Article  PubMed  PubMed Central  Google Scholar 

  55. Baumbach SF, Pfahler V, Bechtold-Dalla Pozza S et al (2020) How we manage bone marrow edema—an interdisciplinary approach. J Clin Med 9:551. https://doi.org/10.3390/jcm9020551

    Article  PubMed  PubMed Central  Google Scholar 

  56. Ververidis AN, Paraskevopoulos K, Keskinis A et al (2020) Bone marrow edema syndrome/transient osteoporosis of the hip joint and management with the utilization of hyperbaric oxygen therapy. J Orthop 22:29–32. https://doi.org/10.1016/j.jor.2020.03.062

    Article  PubMed  PubMed Central  Google Scholar 

  57. Ringe et al (2005) Effective and rapid treatment of painful localized transient osteoporosis (bone marrow edema) with intravenous ibandronate. Osteoporos Int. https://doi.org/10.1007/s00198-005-2001-6

    Article  PubMed  Google Scholar 

  58. Kuchler L et al (2020) Pain control with ibandronate for bone marrow oedema of the knee. Swiss Med Wkly. https://doi.org/10.4414/smw.2020.20384

    Article  PubMed  Google Scholar 

  59. Efficacy of intravenous neridronate in transient osteoporosis of the hip. In: Clin Exp Rheumatol. https://www.clinexprheumatol.org/abstract.asp?a=17722. Accessed 20 Dec 2022

  60. Sconza C, Coletta F, Magarelli N et al (2022) Multimodal conservative treatment of migrating bone marrow edema associated with early osteonecrosis of the hip. SAGE Open Med Case Rep. https://doi.org/10.1177/2050313X211067617

    Article  PubMed  PubMed Central  Google Scholar 

  61. Rolvien T, Schmidt T, Butscheidt S et al (2017) Denosumab is effective in the treatment of bone marrow oedema syndrome. Injury 48:874–879. https://doi.org/10.1016/j.injury.2017.02.020

    Article  PubMed  Google Scholar 

  62. Baier C et al (2013) Bisphosphonates or prostacyclin in the treatment of bone-marrow oedema syndrome of the knee and foot. Rheumatol Int. https://doi.org/10.1007/s00296-012-2584-0

    Article  PubMed  Google Scholar 

  63. Tosun HB, Uludağ A, Demir S et al (2020) Effectiveness of iloprost in the treatment of bone marrow edema. Cureus 12:e10547. https://doi.org/10.7759/cureus.10547

    Article  PubMed  PubMed Central  Google Scholar 

  64. Zippelius T, Matziolis G, Perka C et al (2018) Long-term effects of intravenous iloprost therapy in patients with bone marrow oedema of the knee joint. Acta Chir Orthop Traumatol Cech 85:17–21

    Article  CAS  PubMed  Google Scholar 

  65. Häußer J, Wieber J, Catalá-Lehnen P (2021) The use of extracorporeal shock wave therapy for the treatment of bone marrow oedema—a systematic review and meta-analysis. J Orthop Surg Res 16:369. https://doi.org/10.1186/s13018-021-02484-5

    Article  PubMed  PubMed Central  Google Scholar 

  66. Ghasemi RA, Sadeghi S, Rahimee N, Tahmasebi M (2019) Technologies in the treatment of bone marrow edema syndrome. Orthop Clin North Am 50:131–138. https://doi.org/10.1016/j.ocl.2018.08.008

    Article  PubMed  Google Scholar 

  67. Sollazzo V, Palmieri A, Pezzetti F et al (2010) Effects of pulsed electromagnetic fields on human osteoblastlike cells (MG-63): a pilot study. Clin Orthop Relat Res 468:2260–2277. https://doi.org/10.1007/s11999-010-1341-5

    Article  PubMed  PubMed Central  Google Scholar 

  68. Barnaba SA, Ruzzini L, Di Martino A et al (2012) Clinical significance of different effects of static and pulsed electromagnetic fields on human osteoclast cultures. Rheumatol Int 32:1025–1031. https://doi.org/10.1007/s00296-010-1724-7

    Article  CAS  PubMed  Google Scholar 

  69. Ververidis AN, Paraskevopoulos K, Keskinis A et al (2020) The efficacy and safety of bisphosphonates in patients with bone marrow edema syndrome/transient osteoporosis: a systematic literature review. J Orthop 22:592–597. https://doi.org/10.1016/j.jor.2020.11.011

    Article  PubMed  PubMed Central  Google Scholar 

  70. Chandrinou A, Korompeli A, Grammatopoulou E et al (2020) Avascular necrosis of the femoral head: evaluation of hyperbaric oxygen therapy and quality of life. Undersea Hyperb Med 47:561–569. https://doi.org/10.22462/10.12.2020.5

    Article  PubMed  Google Scholar 

  71. Salameh M, Moghamis IS, Kokash O, Ahmed GO (2021) Hyperbaric oxygen therapy for the treatment of Steinberg I and II avascular necrosis of the femoral head: a report of fifteen cases and literature review. Int Orthop 45:2519–2523. https://doi.org/10.1007/s00264-021-05120-3

    Article  PubMed  Google Scholar 

  72. de Castro JC, Henares-Esguerra EL, Tamayo-Shih MBOS et al (2022) Photoactivated leucocyte-rich platelet-rich plasma treatment in reduction of bone marrow edema in hip osteoarthritis. Regen Med 17:521–531. https://doi.org/10.2217/rme-2021-0165

    Article  CAS  PubMed  Google Scholar 

  73. Liu Y, Su X, Zhou S et al (2015) A modified porous tantalum implant technique for osteonecrosis of the femoral head: survivorship analysis and prognostic factors for radiographic progression and conversion to total hip arthroplasty. Int J Clin Exp Med 8:1918–1930

    PubMed  PubMed Central  Google Scholar 

  74. Akhavan S, Martinkovich SC, Kasik C, DeMeo PJ (2020) Bone marrow edema, clinical significance, and treatment options: a review. JAAOS 28:e888. https://doi.org/10.5435/JAAOS-D-20-00142

    Article  PubMed  Google Scholar 

  75. Chughtai M et al (2017) An evidence-based guide to the treatment of osteonecrosis of the femoral head. Bone Jt J. https://doi.org/10.1302/0301-620X.99B10.BJJ-2017-0233.R2

    Article  Google Scholar 

  76. Kapil N, Samuel LT, Kamath AF (2020) Management of bone marrow lesions of the hip with subchondral calcium phosphate injection: surgical technique and tips. Arthrosc Tech 9:e863–e875. https://doi.org/10.1016/j.eats.2020.02.022

    Article  PubMed  PubMed Central  Google Scholar 

  77. Arbeloa-Gutierrez L, Dean CS, Chahla J, Pascual-Garrido C (2016) Core decompression augmented with autologous bone marrow aspiration concentrate for early avascular necrosis of the femoral head. Arthrosc Tech 5:e615–e620. https://doi.org/10.1016/j.eats.2016.02.009

    Article  PubMed  PubMed Central  Google Scholar 

  78. Floerkemeier T, Lutz A, Nackenhorst U et al (2011) Core decompression and osteonecrosis intervention rod in osteonecrosis of the femoral head: clinical outcome and finite element analysis. Int Orthop 35:1461–1466. https://doi.org/10.1007/s00264-010-1138-x

    Article  PubMed  Google Scholar 

  79. Gao F, Sun W, Li Z et al (2015) Intractable bone marrow edema syndrome of the hip. Orthopedics 38:e263-270. https://doi.org/10.3928/01477447-20150402-53

    Article  PubMed  Google Scholar 

  80. Radke et al (2003) Treatment of transient bone marrow oedema of the hip—a comparative study. Int Orthop. https://doi.org/10.1007/s00264-003-0452-y

    Article  PubMed  PubMed Central  Google Scholar 

  81. Lee G-W, Park K-S, Kim D-Y et al (2016) Results of total hip arthroplasty after core decompression with tantalum rod for osteonecrosis of the femoral head. Clin Orthop Surg 8:38–44. https://doi.org/10.4055/cios.2016.8.1.38

    Article  PubMed  PubMed Central  Google Scholar 

  82. Cohen-Rosenblum A, Cui Q (2019) Osteonecrosis of the femoral head. Orthop Clin North Am 50:139–149. https://doi.org/10.1016/j.ocl.2018.10.001

    Article  PubMed  Google Scholar 

  83. Cadossi M, Sambri A, Tedesco G et al (2017) Anterior approach in total hip replacement. Orthopedics 40:e553–e556. https://doi.org/10.3928/01477447-20161202-06

    Article  PubMed  Google Scholar 

  84. Niccoli G, Bozzi F, Candura D et al (2022) The anterior lateral decubitus intermuscolar and the postero-lateral approaches in total hip arthroplasty: a comparative study. Acta Biomed 92:e2021532. https://doi.org/10.23750/abm.v92iS3.11583

    Article  PubMed  Google Scholar 

  85. Swarup I, Shields M, Mayer EN et al (2017) Outcomes after total hip arthroplasty in young patients with osteonecrosis of the hip. Hip Int 27:286–292. https://doi.org/10.5301/hipint.5000457

    Article  PubMed  Google Scholar 

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  1. 1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Via G.B. Pupilli 1, 40136, Bologna, Italy

    Alberto Di Martino, Matteo Brunello, Eleonora Villari, Piergiorgio Cataldi, Claudio D’Agostino & Cesare Faldini

  2. Department of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, Bologna, Italy

    Alberto Di Martino, Matteo Brunello, Eleonora Villari, Piergiorgio Cataldi, Claudio D’Agostino & Cesare Faldini

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Di Martino, A., Brunello, M., Villari, E. et al. Bone marrow edema of the hip: a narrative review. Arch Orthop Trauma Surg 143, 6901–6917 (2023). https://doi.org/10.1007/s00402-023-04961-4

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