Abstract
Introduction
Chronic lateral epicondylitis is generally treated using nonsurgical methods including physiotherapy and infiltrations of cortisone or platelet-rich plasma (PRP). The latter is known for its simple application as well as associated low risk of adverse events, which lend to its widespread use in treating various musculoskeletal conditions. There is limited evidence on the effectiveness of PRP injections to optimally treat chronic lateral epicondylitis. This study explored the effectiveness of single or repeated injections for patients with symptoms that spanned 6 months or more and were unresponsive to alternate conservative measures.
Methods and materials
Patients with chronic lateral epicondylitis received PRP injections in 4-week intervals that were complemented with standardized physical therapy. Patient-reported outcomes based on the patient-rated elbow evaluation (PREE), quick disabilities of the arm, shoulder and hand (qDASH), and EuroQol (five dimensions) 3-level version (EQ5D3L) questionnaires were documented at each visit including 6 months after the first injection. These outcomes were compared between patients receiving 1 vs. 2 or 3 PRP injections.
Results
Sixty-two patients received one (n = 36) or more (n = 26) PRP injections. The mean baseline to 6-month follow-up scores of the PREE and qDASH questionnaires improved significantly from 54.0 to 23.0 and 50.3 to 20.7, respectively. The mean baseline EQ5D3L-visual analogue scale score improved from 62.5 to 82.9 by 6 months post-injection. These outcomes did not significantly differ between the patients who received varying numbers of injections.
Conclusions
Patients with chronic lateral epicondylitis reported significant pain relief and gain in function as well as quality of life 6 months after localized PRP treatment. A single PRP injection may be sufficient.
Similar content being viewed by others
References
Smidt N, Lewis M, Van Der Windt DA, Hay EM, Bouter LM, Croft P (2006) Lateral epicondylitis in general practice: course and prognostic indicators of outcome. J Rheumatol 33:2053–2059
Ahmad Z, Siddiqui N, Malik SS, Abdus-Samee M, Tytherleigh-Strong G, Rushton N (2013) Lateral epicondylitis: a review of pathology and management. Bone Joint J 95-B:1158–1164
Ries C, Franke S, Dietrich F, Jakubowitz E, Dehlinger F, Hollinger B (2013) Transosseous refixation of the common extensor muscle tendons in chronic lateral epicondylitis with and without additional reconstruction of the LUCL—a retrospective evaluation of 101 patients. Z Orthop Unfall 151:296–301
Ferrari M, Zia S, Valbonesi M, Henriquet F, Venere G, Spagnolo S, Grasso MA, Panzani I (1987) A new technique for hemodilution, preparation of autologous platelet-rich plasma and intraoperative blood salvage in cardiac surgery. Int J Artif Organs 10:47–50
de Vos RJ, Weir A, van Schie HT, Bierma-Zeinstra SM, Verhaar JA, Weinans H, Tol JL (2010) Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. JAMA 303:144–149
Hall MP, Band PA, Meislin RJ, Jazrawi LM, Cardone DA (2009) Platelet-rich plasma: current concepts and application in sports medicine. J Am Acad Orthop Surg 17:602–608
Halpern BC, Chaudhury S, Rodeo SA (2012) The role of platelet-rich plasma in inducing musculoskeletal tissue healing. HSS J 8:137–145
Mei-Dan O, Carmont MR, Laver L, Mann G, Maffulli N, Nyska M (2012) Platelet-rich plasma or hyaluronate in the management of osteochondral lesions of the talus. Am J Sports Med 40:534–541
Molloy T, Wang Y, Murrell G (2003) The roles of growth factors in tendon and ligament healing. Sports Med 33:381–394
Sampson S, Gerhardt M, Mandelbaum B (2008) Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr Rev Musculoskelet Med 1:165–174
Sheth U, Simunovic N, Klein G, Fu F, Einhorn TA, Schemitsch E, Ayeni OR, Bhandari M (2012) Efficacy of autologous platelet-rich plasma use for orthopaedic indications: a meta-analysis. J Bone Joint Surg Am 94:298–307
Dohan Ehrenfest DM, Rasmusson L, Albrektsson T (2009) Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 27:158–167
Mazzocca AD, McCarthy MB, Intravia J, Beitzel K, Apostolakos J, Cote MP, Bradley J, Arciero RA (2013) An in vitro evaluation of the anti-inflammatory effects of platelet-rich plasma, ketorolac, and methylprednisolone. Arthroscopy 29:675–683
Zhang J, Middleton KK, Fu FH, Im HJ, Wang JH (2013) HGF mediates the anti-inflammatory effect of PRP on injured tendons. PLoS One 8:e67303
Mazzocca AD, McCarthy MB, Chowaniec DM, Cote MP, Romeo AA, Bradley JP, Arciero RA, Beitzel K (2012) Platelet-rich plasma differs according to preparation method and human variability. J Bone Joint Surg Am 94:308–316
Ahmad Z, Brooks R, Kang SN, Weaver H, Nunney I, Tytherleigh-Strong G, Rushton N (2013) The effect of platelet-rich plasma on clinical outcomes in lateral epicondylitis. Arthroscopy 29:1851–1862
Gosens T, Peerbooms JC, van Laar W, den Oudsten BL (2011) Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. Am J Sports Med 39:1200–1208
Krogh TP, Fredberg U, Stengaard-Pedersen K, Christensen R, Jensen P, Ellingsen T (2013) Treatment of lateral epicondylitis with platelet-rich plasma, glucocorticoid, or saline: a randomized, double-blind, placebo-controlled trial. Am J Sports Med 41:625–635
Mishra A, Pavelko T (2006) Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med 34:1774–1778
Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. Am J Sports Med 38:255–262
de Vos RJ, Windt J, Weir A (2014) Strong evidence against platelet-rich plasma injections for chronic lateral epicondylar tendinopathy: a systematic review. Br J Sports Med 48:952–956
Glanzmann MC, Audigé L (2015) Efficacy of platelet-rich plasma injections for chronic medial epicondylitis. J Hand Surg Eur 40(7):744–745
Thanasas C, Papadimitriou G, Charalambidis C, Paraskevopoulos I, Papanikolaou A (2011) Platelet-rich plasma versus autologous whole blood for the treatment of chronic lateral elbow epicondylitis: a randomized controlled clinical trial. Am J Sports Med 39:2130–2134
Beitzel K, McCarthy MB, Cote MP, Apostolakos J, Russell RP, Bradley J, ElAttrache NS, Romeo AA, Arciero RA, Mazzocca AD (2013) The effect of ketorolac tromethamine, methylprednisolone, and platelet-rich plasma on human chondrocyte and tenocyte viability. Arthroscopy 29:1164–1174
Vincent J, MacDermid JC (2012) The patient-rated elbow evaluation (PREE). J Physiother 58:274
John M, Angst F, Pap G, Junge A, Mannion AF (2007) Cross-cultural adaptation, reliability and validity of the patient rated elbow evaluation (PREE) for German-speaking patients. Clin Exp Rheumatol 25:195–205
Angst F, Goldhahn J, Drerup S, Flury M, Schwyzer HK, Simmen BR (2009) How sharp is the short QuickDASH? A refined content and validity analysis of the short form of the disabilities of the shoulder, arm and hand questionnaire in the strata of symptoms and function and specific joint conditions. Qual Life Res 18:1043–1051
Hudak PL, Amadio PC, Bombardier C (1996) Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG). Am J Ind Med 29:602–608
Brooks R (1996) EuroQol: the current state of play. Health Policy 37:53–72
Kon E, Filardo G, Delcogliano M, Presti ML, Russo A, Bondi A, Di Martino A, Cenacchi A, Fornasari PM, Marcacci M (2009) Platelet-rich plasma: new clinical application: a pilot study for treatment of jumper’s knee. Injury 40:598–603
Verhaar J, Walenkamp G, Kester A, van Mameren H, van der Linden T (1993) Lateral extensor release for tennis elbow. A prospective long-term follow-up study. J Bone Joint Surg Am 75:1034–1043
Coombes BK, Bisset L, Vicenzino B (2010) Efficacy and safety of corticosteroid injections and other injections for management of tendinopathy: a systematic review of randomised controlled trials. Lancet 376:1751–1767
Wolf JM, Ozer K, Scott F, Gordon MJ, Williams AE (2011) Comparison of autologous blood, corticosteroid, and saline injection in the treatment of lateral epicondylitis: a prospective, randomized, controlled multicenter study. J Hand Surg Am 36:1269–1272
Redler LH, Thompson SA, Hsu SH, Ahmad CS, Levine WN (2011) Platelet-rich plasma therapy: a systematic literature review and evidence for clinical use. Phys Sportsmed 39:42–51
Yilmaz S, Cakar G, Ipci SD, Kuru B, Yildirim B (2010) Regenerative treatment with platelet-rich plasma combined with a bovine-derived xenograft in smokers and non-smokers: 12-month clinical and radiographic results. J Clin Periodontol 37:80–87
Carofino B, Chowaniec DM, McCarthy MB, Bradley JP, Delaronde S, Beitzel K, Cote MP, Arciero RA, Mazzocca AD (2012) Corticosteroids and local anesthetics decrease positive effects of platelet-rich plasma: an in vitro study on human tendon cells. Arthroscopy 28:711–719
Acknowledgments
We wish to thank all clinicians of the Schulthess Clinic upper extremity and hand team for providing cases used in the clinical evaluation part of this study as well as our study nurses Franziska Kohler and Jessica Hohn for their valuable support. The authors would like also to thank M. Wilhelmi, Ph.D. for the preparation and editing of this manuscript.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
None.
Rights and permissions
About this article
Cite this article
Glanzmann, M.C., Audigé, L. Platelet-rich plasma for chronic lateral epicondylitis: Is one injection sufficient?. Arch Orthop Trauma Surg 135, 1637–1645 (2015). https://doi.org/10.1007/s00402-015-2322-7
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00402-015-2322-7