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Anorectal manometry findings in relation with long-term functional outcomes of the patients operated on for Hirschsprung’s disease compared to the reference-based population

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Abstract

Purpose

This study investigated anorectal manometry (AM) findings and bowel function of patients operated on for Hirschsprung’s disease (HD).

Methods

A cross-sectional study was conducted at Children’s Hospital 2. Patients operated on for HD from January 2015 to January 2020 were reviewed. Their clinical characteristics, bowel function, and manometric findings were investigated and compared with the references.

Results

Ninety-five patients and 95 references were enrolled. Mean ages were 6.6 ± 2.2 years and 7.2 ± 2.9 years,; fecal incontinence rates were 25.3% and 2.1%, and constipation rates were 12.6% and 4.2 for the patients versus the references, respectively. Anal resting pressures were significantly decreased in the patients compared to the references (53.2 ± 16.1 mmHg versus 62.2 ± 14.0 mmHg; p < 0.05). Among the patients, the anal resting pressure was significantly decreased in the incontinents than in the continents (46.0 ± 10.6 mmHg versus 55.6 ± 16.9 mmHg, p < 0.05). During the sensation test, the value of maximum tolerated volume was significantly decreased in the incontinents than in the continents (135.9 ± 47.9 mL versus 166.6 ± 58.3 mL, p < 0.05).

Conclusion

AM is an objective method providing beneficial information that could guide a more adapted management in HD patients with defecation disorders.

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Data availability

Data could be available in cases of request and of course with acceptance of all authors.

Abbreviations

AM:

Anorectal manometry

HD:

Hirschsprung’s disease

IAAP:

Increased abnormal anal sphincter pressure

LATEP:

Laparoscopically assisted trans-anal endo-rectal pull-through

RAIR:

Recto-anal inhibitory reflex

SD:

Standard deviation

TERPT:

Transanal endorectal pull-through

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Acknowledgements

This research is part of a collaboration project funded by the Department of Science and Technology of Ho Chi Minh City, Vietnam, under grant number 03/2021/HĐ-QKHCN.

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Authors and Affiliations

  1. Department of Pediatric Surgery, Children’s Hospital 2, 14 Ly Tu Trong, Ben Nghe ward, District 1, Ho Chi Minh City, Vietnam

    Tung Huu Trinh, Kim Thien Lam, Thach Ngoc Pham, Nhan Truong Vu & Viet Quoc Tran

  2. University of Medicine and Pharmacy at Ho Chi Minh City, 215 Hong Bang, District 5, Ho Chi Minh City, Vietnam

    Linh Nguyen Uy Truong

  3. Department of Pediatrics, Children’s Hospital 2, 14 Ly Tu Trong, Ben Nghe ward, District 1, Ho Chi Minh City, Vietnam

    Tung Huu Trinh & Ngoc Minh Nguyen

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Contributions

All authors have contributed to the study's conception and design. VQT, KTL, NMN, and THT were the principal investigators in the data acquisition, analysis, interpretation, and drafting of the manuscript. All authors have contributed to the critical revisions.

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Trinh, T.H., Nguyen, N.M., Lam, K.T. et al. Anorectal manometry findings in relation with long-term functional outcomes of the patients operated on for Hirschsprung’s disease compared to the reference-based population. Pediatr Surg Int 39, 131 (2023). https://doi.org/10.1007/s00383-023-05402-4

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