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Medical treatment of tuberous sclerosis-related epilepsy

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Abstract

Epilepsy is one of the most frequent CNS manifestations of tuberous sclerosis, and for most patients, it is the major debilitating factor. In up to 70% of the cases, the epilepsy is refractory and usually associated with significant behavioral as well as developmental consequences. Therefore, controlling seizures is one of the biggest medical and surgical challenges. Understanding the cellular mechanism involved in the disease empowered targeted research aimed toward early intervention in the epileptogenicity process. In this review, we present an update on the pharmacological treatments in tuberous sclerosis-related epilepsy.

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  1. Pediatric Neurology Institute, Dana-Dwek Children’s Hospital, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv, Israel

    Shimrit Uliel-Sibony, Veronika Chernuha, Hadas Meirson & Aviva Fattal-Valevski

  2. Pediatric Neurology institute, Dana-Dwek Children’s Hospital, Tel-Aviv Sourasky Medical Center, 6 Weizmann Street, 64239, Tel Aviv, Israel

    Shimrit Uliel-Sibony

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Uliel-Sibony, S., Chernuha, V., Meirson, H. et al. Medical treatment of tuberous sclerosis-related epilepsy. Childs Nerv Syst 36, 2511–2517 (2020). https://doi.org/10.1007/s00381-020-04772-7

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