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Current conditions and significance of outpatient cardiac rehabilitation and home nursing-care services in heart failure patients with mid-range or preserved ejection fraction: post-hoc analysis of the REAL-HF registry

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Abstract

The effects of outpatient cardiac rehabilitation (OCR) implementation and home nursing-care services (HNS) use are not well defined in patients with heart failure (HF) with mid-range or preserved left-ventricular ejection fraction (EF) (HFmrEF or HFpEF). Through a post-hoc analysis of the HF registry in Hiroshima Prefecture of Japan (REAL-HF), we investigated the current conditions and significance of OCR and HNS in HFmrEF or HFpEF patients. The REAL-HF enrolled adult patients hospitalized with HF in eight regional core hospitals. Patients discharged home were followed for conditions of OCR and HNS and the primary endpoints (all-cause death or unscheduled readmission) for 1 year. The patients were classified into HF with reduced EF (< 40%) (HFrEF) or HFmrEF (40% ≤ EF < 50%) or HFpEF (EF ≥ 50%) group. We followed 195 HFrEF and 381 HFmrEF or HFpEF patients. OCR was generally underutilized, especially in HFmrEF or HFpEF patients (rate of completion [5-month program], 3.2%), whereas HFmrEF or HFpEF patients were more likely to use HNS after discharge home than HFrEF patients (44.1% vs. 27.2%, P < 0.0001). Patients with the use of HNS generally had lower scores of Mini-Mental State Examination and EuroQol 5 dimensions than those without. Multivariate analysis adjusted for medical and social factors showed that the completion of OCR was a strong negative predictor of the primary endpoints both in HFrEF (hazard ratio [HR] 0.10; 95% confidence interval [CI] 0.01–0.75; P = 0.025) and HFmrEF or HFpEF (HR 0.11; 95% CI 0.01–0.78; P = 0.028) patients, whereas the use of HNS was a positive predictor only in HFmrEF or HFpEF patients (HR 1.41; 95% CI 1.00–1.97; P = 0.047). In conclusion, continuous OCR, despite its inadequate implementation, was associated with favorable overall outcomes, while the necessity for HNS related to impaired cognitive function and quality of life was associated with poorer overall outcomes in HFmrEF or HFpEF patients discharged home. Further study is warranted to fully consider the factors related to OCR implementation and HNS use.

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Acknowledgements

We would like to thank Ayano Michimura for help in aggregating and summarizing the patient data. We thank Mark Cleasby, PhD, from Edanz Group (https://en-author-services.edanz.com/ac) for editing a draft of this manuscript.

Funding

This study was supported by the Japan Agency for Medical Research and Development (AMED) under Grant Number JP17ek0210058. This study was also supported by a local medical program of the Hiroshima Prefecture Government in Japan (Hiroshima Heart Health Promotion Project).

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan

    Toshiro Kitagawa, Takayuki Hidaka, Noriaki Watanabe, Yasuki Kihara & Yukiko Nakano

  2. Heart Failure Center, Hiroshima University Hospital, Hiroshima, Japan

    Toshiro Kitagawa, Takayuki Hidaka, Noriaki Watanabe, Makiko Naka, Mizuho Yamaguchi, Kana Kanai & Yukiko Nakano

  3. Division of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University Hospital, Hiroshima, Japan

    Kana Kanai

  4. Sakakibara Heart Institute, Tokyo, Japan

    Mitsuaki Isobe

  5. Kobe City Medical Center General Hospital, Kobe, Japan

    Yasuki Kihara

Authors
  1. Toshiro Kitagawa
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  2. Takayuki Hidaka
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  3. Noriaki Watanabe
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  4. Makiko Naka
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  5. Mizuho Yamaguchi
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  6. Kana Kanai
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  7. Mitsuaki Isobe
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  8. Yasuki Kihara
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  9. Yukiko Nakano
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The REAL-HF Investigators

Contributions

MI and YK conceived and designed this study. TK, TH, MN, and MY contributed to acquisition and analysis of the data. TK, TH, NW, and KK contributed to interpretation of the data. Toshiro Kitagawa wrote the paper. MI, YK, and YN had primary responsibility for the final content. All authors read and approved the final manuscript.

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Correspondence to Toshiro Kitagawa.

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The members of the REAL-HF Investigators are mentioned in the Supplementary file 1.

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Kitagawa, T., Hidaka, T., Watanabe, N. et al. Current conditions and significance of outpatient cardiac rehabilitation and home nursing-care services in heart failure patients with mid-range or preserved ejection fraction: post-hoc analysis of the REAL-HF registry. Heart Vessels 37, 745–754 (2022). https://doi.org/10.1007/s00380-021-01965-1

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