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Long-term prognostic value of myocardin expression levels in non-ischemic dilated cardiomyopathy

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Abstract

The mortality of patients with non-ischemic dilated cardiomyopathy (NIDCM) remains substantial. We evaluated gene expression levels of myocardin, an early cardiac gene, in the peripheral blood cells of NIDCM patients as a prognostic biomarker in their long-term outcome and mortality from congestive HF (CHF). We retrospectively analyzed 101 consecutives optimally treated NIDCM patients of Cretan origin who were enrolled from the HF clinic of our hospital from November 2005 to December 2008. Our patient data were either taken from their medical files or recorded during visits to the HF unit or hospitalizations. Follow-up was carried out by telephone interview and by accessing information from general practitioners and cardiologists in private practice. The median follow-up period was 8 years (mean follow-up 7 ± 3.4 years). The overall mortality during follow-up was 61.4%, while mortality due to congestive heart failure (CHF) was 49.5%. Higher CHF and all-cause mortality were observed in patients with myocardin levels < 14.26 (p < 0.001 for both CHF and all-cause mortality). A multivariate Cox regression analysis showed that myocardin level of expression had independent significant prognostic value for the risk of death from CHF (HR 14.5, 95% confidence interval (CI) 5.3–39) in those patients. Peripheral blood cells gene expression of myocardin, an early myocardial marker, may serve as prognostic biomarkers of the long-term outcome of patients with NIDCM. Our findings open new prospects in the risk stratification of these patients.

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No financial support was received for this study and there are no conflicts of interest by any of the authors.

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Authors and Affiliations

  1. Cardiology Department, Heraklion University Hospital, Stavrakia, P.O. Box 1352, Heraklion, Crete, Greece

    Maria E. Marketou, Alexandros Patrianakos, Emmanuel Kanoupakis, Anthoula Plevritaki, Hercules Mavrakis, Eleutherios Kallergis, Emmanuel Koutalas, Ioannis Anastasiou & Fragiskos Parthenakis

  2. Molecular Cardiology Laboratory, School of Medicine, University of Crete, Heraklion, Greece

    Joanna Kontaraki

  3. Division of Biostatisctics, School of Medicine, University of Crete, Heraklion, Greece

    Gregory Chlouverakis

Authors
  1. Maria E. Marketou
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  2. Joanna Kontaraki
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Correspondence to Maria E. Marketou.

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Marketou, M.E., Kontaraki, J., Patrianakos, A. et al. Long-term prognostic value of myocardin expression levels in non-ischemic dilated cardiomyopathy. Heart Vessels 36, 1841–1847 (2021). https://doi.org/10.1007/s00380-021-01869-0

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