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Volumetric measurement of compensatory hypertrophy in the contralateral normal kidney by the tumor growth

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Abstract

Purpose

We evaluated the association between tumor size and preoperative volumetric kidney parameters measured with CT in patients with renal cell carcinoma (RCC).

Methods

We prospectively identified 1118 patients who underwent radical or partial nephrectomy for RCC between 2011 and 2014. Contrast-enhanced CT was performed within three months before surgery. Kidney volume was measured using a tissue segmentation tool program from CT images. We classified patients into three groups depending on tumor size (A: ≤4 cm, B: 4–7 cm, C: >7 cm). The preoperative volumetric kidney parameters were compared and multivariable linear regression was used to analyze potential factors associated with compensatory hypertrophy of the contralateral normal kidney before surgery.

Results

Patients in group C had a significantly larger contralateral normal kidney volume than patients in A and B (A: 170.0 mL, B: 171.7 mL, C: 187.2 mL, p < 0.001). The contralateral kidney volume was not significantly different between groups A and B (p > 0.05). However, tumor-side real kidney volume in group C was significantly smaller than that of groups A and B (A: 168.8 mL, B: 164.9 mL, C: 150.9 mL, p < 0.001). On multivariable analysis, increased contralateral kidney volume was positively associated with male gender, higher BMI, DM, higher preoperative GFR, and tumor size (>7 cm), and negatively associated with older age (p < 0.05). Tumor size had the strongest positive association with contralateral kidney volume (>7 cm, partial regression coefficient = 30.2).

Conclusions

Tumor size (>7 cm) is the strongest factor associated with compensatory hypertrophy in the contralateral normal kidney before surgery.

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Acknowledgments

This study was supported by Samsung Biomedical Research Institute Grant [#SMR113101].

Conflict of interest

None.

Ethical standard

The study was approved by the Institutional Review Board of Samsung Medical Center; informed consent was obtained from all patients.

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Authors and Affiliations

  1. Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, 135-710, Republic of Korea

    Byong Chang Jeong, Seong Soo Jeon, Seong Il Seo, Hyun Moo Lee, Han Yong Choi & Hwang Gyun Jeon

  2. Department of Urology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Republic of Korea

    Bong Hee Park

Authors
  1. Bong Hee Park
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  2. Byong Chang Jeong
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  3. Seong Soo Jeon
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  4. Seong Il Seo
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  5. Hyun Moo Lee
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  6. Han Yong Choi
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  7. Hwang Gyun Jeon
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Corresponding author

Correspondence to Hwang Gyun Jeon.

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Park, B.H., Jeong, B.C., Jeon, S.S. et al. Volumetric measurement of compensatory hypertrophy in the contralateral normal kidney by the tumor growth. World J Urol 34, 63–68 (2016). https://doi.org/10.1007/s00345-015-1551-2

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  • DOI: https://doi.org/10.1007/s00345-015-1551-2

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