Abstract
Objectives
This study aims to measure the reproducibility of radiomic features in pancreatic parenchyma and ductal adenocarcinomas (PDAC) in patients who underwent consecutive contrast-enhanced computed tomography (CECT) scans.
Methods
In this IRB-approved and HIPAA-compliant retrospective study, 37 pairs of scans from 37 unique patients who underwent CECTs within a 2-week interval were included in the analysis of the reproducibility of features derived from pancreatic parenchyma, and a subset of 18 pairs of scans were further analyzed for the reproducibility of features derived from PDAC. In each patient, pancreatic parenchyma and pancreatic tumor (when present) were manually segmented by two radiologists independently. A total of 266 radiomic features were extracted from the pancreatic parenchyma and tumor region and also the volume and diameter of the tumor. The concordance correlation coefficient (CCC) was calculated to assess feature reproducibility for each patient in three scenarios: (1) different radiologists, same CECT; (2) same radiologist, different CECTs; and (3) different radiologists, different CECTs.
Results
Among pancreatic parenchyma-derived features, using a threshold of CCC > 0.90, 58/266 (21.8%) and 48/266 (18.1%) features met the threshold for scenario 1, 14/266 (5.3%) and 15/266 (5.6%) for scenario 2, and 14/266 (5.3%) and 10/266 (3.8%) for scenario 3. Among pancreatic tumor-derived features, 11/268 (4.1%) and 17/268 (6.3%) features met the threshold for scenario 1, 1/268 (0.4%) and 5/268 (1.9%) features met the threshold for scenario 2, and no features for scenario 3 met the threshold, respectively.
Conclusions
Variations between CECT scans affected radiomic feature reproducibility to a greater extent than variation in segmentation. A smaller number of pancreatic tumor-derived radiomic features were reproducible compared with pancreatic parenchyma-derived radiomic features under the same conditions.
Key Points
• For pancreatic-derived radiomic features from contrast-enhanced CT (CECT), fewer than 25% are reproducible (with a threshold of CCC < 0.9) in a clinical heterogeneous dataset.
• Variations between CECT scans affected the number of reproducible radiomic features to a greater extent than variations in radiologist segmentation.
• A smaller number of pancreatic tumor-derived radiomic features were reproducible compared with pancreatic parenchyma-derived radiomic features under the same conditions.
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Abbreviations
- ACM:
-
Angle co-occurrence matrix
- CCC:
-
Concordance correlation coefficient
- CECT:
-
Contrast-enhanced computed tomography
- DICOM:
-
Digital Imaging and Communications in Medicine
- FD:
-
Fractal dimension
- GLCM:
-
Gray-level co-occurrence matrix
- ICC:
-
Intraclass correlation coefficient
- IH:
-
Intensity histogram
- IQR:
-
Interquartile range
- LBP:
-
Local binary pattern
- PDAC:
-
Pancreatic ductal adenocarcinoma
- RLM:
-
Run length matrix
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Acknowledgments
We thank Luz Adriana Escobar Hoyos and Juliana Brooke Schilsky for their support in figure creation and Joanne Chin for editorial assistance.
Funding
This study was funded in part through the 2016 Society of Abdominal Radiology Wylie J. Dodds Research Award, the National Institutes of Health/National Cancer Institute Cancer Center Support Grant P30 CA008748, and the Japan Society Promotion of Science Overseas Research Fellowships JSPS/OT/290125.
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The scientific guarantor of this publication is Richard K. G. Do, MD, PhD.
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Two of the authors (Joanne Chou and Mithat Gonen, PhD) have significant statistical expertise.
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Written informed consent was waived by the Institutional Review Board.
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• retrospective
• cross-sectional study
• performed at one institution
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Yamashita, R., Perrin, T., Chakraborty, J. et al. Radiomic feature reproducibility in contrast-enhanced CT of the pancreas is affected by variabilities in scan parameters and manual segmentation. Eur Radiol 30, 195–205 (2020). https://doi.org/10.1007/s00330-019-06381-8
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DOI: https://doi.org/10.1007/s00330-019-06381-8