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Initial experience of correlating parameters of intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging at 3.0 T in nasopharyngeal carcinoma

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Abstract

Purpose

To determine the correlation between intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters.

Methods

Thirty-eight newly diagnosed NPC patients were prospectively enrolled. Diffusion-weighted images (DWI) at 13 b-values were acquired using a 3.0-T MRI system. IVIM parameters including the pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f), DCE-MRI parameters including maximum slope of increase (MSI), enhancement amplitude (EA) and enhancement ratio (ER) were calculated by two investigators independently. Intra- and interobserver agreement were evaluated using the intraclass correlation coefficient (ICC) and Bland-Altman analysis. Relationships between IVIM and DCE-MRI parameters were evaluated by calculation of Spearman’s correlation coefficient.

Results

Intra- and interobserver reproducibility were excellent to relatively good (ICC = 0.887-0.997; narrow width of 95 % limits of agreement). The highest correlation was observed between f and EA (r = 0.633, P < 0.001), with a strong correlation between f and MSI (r = 0.598, P = 0.001). No correlation was observed between f and ER (r = -0.162; P = 0.421) or D* and DCE parameters (r = 0.125–0.307; P > 0.119).

Conclusion

This study suggests IVIM perfusion imaging using 3.0-T MRI is feasible in NPC, and f correlates significantly with EA and MSI.

Key Points

• Assessment of tumour perfusion is important in nasopharyngeal carcinoma.

• DCE-MRI provided perfusion information with the use of intravenous contrast media.

• Perfusion information could be provided by non-invasive IVIM MRI.

• IVIM parameter f correlated with DCE-MRI parameters.

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Abbreviations

CBV:

Cerebral blood volume

D:

Pure molecular diffusion

DCE:

Dynamic contrast-enhanced

DWI:

Diffusion-weighted images

D*:

Perfusion-related diffusion

EA:

Enhancement amplitude

ER:

Enhancement ratio

f:

Perfusion fraction

FOV:

Field of view

IVIM:

Intravoxel incoherent motion

ICC:

Intraclass correlation coefficient

LoA:

Limits of agreement

MRI:

Magnetic resonance imaging

MSI:

Maximum slope of increase

MVD:

Microvessel density

MTT:

Mean transit time

NEX:

Number of excitations

NPC:

Nasopharyngeal carcinoma

SPGR:

Spoiled gradient-recalled echo

TR:

Repetition time

TE:

Echo time

TICs:

Time-signal intensity curves

VEGFR-2:

Vascular endothelial growth factor receptor 2

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (nos. 81271654, 81271569 and 81171329) and Science and Technology Support Program of Guangzhou, China (2010J-E481). We gratefully acknowledge the assistance of Zhong-Ping Zhang (MD, from Applied Science Lab, GE Healthcare, Guangzhou, Guangdong Prov., P. R. China) for support with IVIM methodology and for linguistic editing.

The scientific guarantor of this publication is Chang-Hong Liang. The authors of this manuscript declare relationships with the following companies: GE Healthcare. No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: Prospective, diagnostic or prognostic study, performed at one institution.

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Authors and Affiliations

  1. Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, 106 Zhong Shan Er Road, Guangzhou, Guangdong Province, 510080, People’s Republic of China

    Qian-Jun Jia, Shui-Xing Zhang, Wen-Bo Chen, Long Liang, Zheng-Gen Zhou, Zai-Yi Liu, Qiong-Xin Zeng & Chang-Hong Liang

  2. Department of Otolaryngology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, 106 Zhong Shan Er Road, Guangzhou, Guangdong Province, 510080, People’s Republic of China

    Qian-Hui Qiu

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  1. Qian-Jun Jia
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Correspondence to Chang-Hong Liang.

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Qian-Jun Jia and Shui-Xing Zhang contributed equally to this manuscript.

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Jia, QJ., Zhang, SX., Chen, WB. et al. Initial experience of correlating parameters of intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging at 3.0 T in nasopharyngeal carcinoma. Eur Radiol 24, 3076–3087 (2014). https://doi.org/10.1007/s00330-014-3343-2

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