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Diagnostic delays in systemic vasculitides

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Abstract

Systemic vasculitides are among the less common disorders encountered in routine rheumatology practice. The low incidence and heterogeneous presentation at onset can potentially lead to delayed diagnosis. Not recognizing these in the early phase may prove detrimental, as some vasculitis may progress to a catastrophic course with major morbidity or mortality. The causes of diagnostic delay may vary among different types of vasculitis and may also be disease-, patient-, or physician-related. Disease-related factors include the myriad presentations with diverse and non-specific symptoms, mimicking other conditions like infections. In addition, some forms have prolonged prodromal phases before evident organ damage. Limited awareness among healthcare professionals, particularly outside rheumatology, and a lack of readily available diagnostic tools contribute to missed diagnoses. Delays in seeking care due to non-specific symptoms or lack of access to specialist care can worsen outcomes. The economic burden also increases with delayed diagnosis and damage accrual when the disease remains unrecognized or untreated for prolonged periods. Although the causes of vasculitis are numerous, including secondary causes, in this review, we focus on diagnostic delays in primary vasculitides and suggest potential steps to identify and treat these diseases early. These include educating both healthcare professionals and the public about the signs and symptoms of vasculitis; expanding the rheumatology workforce and facilitating timely referrals; implementing readily available and reliable tests for early detection; and streamlining care and diagnostic pathways. Such measures have the potential to improve the overall outcomes of the disease, with prolonged remission, minimal damage accrual, and improved quality of life.

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Authors and Affiliations

  1. Department of Biology and Biochemistry, South Kazakhstan Medical Academy, Shymkent, Kazakhstan

    Akerke Auanassova & Marlen Yessirkepov

  2. Department of Clinical Rheumatology and Immunology, University Hospital in Krakow, Krakow, Poland

    Olena Zimba

  3. National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland

    Olena Zimba

  4. Department of Internal Medicine #2, Danylo Halytsky Lviv National Medical University, L’viv, Ukraine

    Olena Zimba

  5. Department of Clinical Immunology and Rheumatology, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, 751024, India

    Sakir Ahmed & Prakashini Mruthyunjaya

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  1. Akerke Auanassova
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Auanassova, A., Yessirkepov, M., Zimba, O. et al. Diagnostic delays in systemic vasculitides. Rheumatol Int (2024). https://doi.org/10.1007/s00296-024-05582-9

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