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Clinical and functional impact of central sensitization on patients with familial Mediterranean fever: a cross-sectional study

  • Observational Research
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Abstract

This study aimed to investigate the frequency of CS and its clinical and functional effects on familial Mediterranean fever (FMF). A hundred FMF patients were included in this study. The presence of CS was investigated by the central sensitization inventory (CSI). In addition to the detailed clinical features of patients and genetic mutations, quality of life, disability, sleep disorders, depression, anxiety, and fibromyalgia frequency were examined to evaluate the negative effects of CS on the individual. Patients were divided into groups according to the presence and severity of CS, and their results were compared. Correlation and multivariate regression analysis were performed to investigate the association of CS  with selected demographic and clinical parameters. The mean CSI was 37.72 (SD: 19.35), and thirty-eight (38%) patients had CS. Sacroiliitis occurred in 11 patients (11%), amyloidosis in 3 (3%), and erysipelas-like erythema in 11 (11%). The most prevalent genetic mutation was M694/any compound heterogeneous (35.7%), followed by M69V homogeneous (30%). Regarding comparing the patients with and without CS, the number of attacks, disease activity, daily colchicine dose, and all investigated comorbidities were significantly higher in the patients with CS (p < 0.05). In regression analysis, gender, colchicine dose and sleep disturbance were detected as related parameters with CS (OR (95% CI): 6.05 (1.39; 26.32), p: 0.017, OR (95% CI): 6.69 (1.65; 27.18), p: 0.008, OR (95% CI): 1.35 (1.35; 1.59), p: 0.001, respectively). Concomitant pain sensitization appears to be related to FMF patients' clinical and functional characteristics. These results suggest taking into consideration CS in the management of FMF patients.

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Data availability

The data sets used in this study are available from the corresponding author (FNY) upon reasonable request.

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Authors and Affiliations

  1. PMR Department, Marmara University School of Medicine, Istanbul, Turkey

    Feyza Nur Yücel & Janbubi Jandaulyet

  2. Rheumatology Clinic, Ümraniye Research and Training Hospital, Istanbul, Turkey

    Halise Hande Gezer

  3. Rheumatology Division, PMR Department, Marmara University School of Medicine, Istanbul, Turkey

    Nuran Öz & Mehmet Tuncay Duruöz

  4. Rheumatology Clinic, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey

    Sevtap Acer Kasman

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  1. Feyza Nur Yücel
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Contributions

The authors confirm contribution to the paper as follows: study conception and design: FNY; data collection: HHG, JJ, NO, SAK; analysis and interpretation of results: FNY; draft manuscript preparation: FNY, HHG, JJ, NO, SAK, MTD. All authors declare that they take full responsibility for the accuracy and integrity of all aspects of this work.

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Correspondence to Feyza Nur Yücel.

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Yücel, F.N., Gezer, H.H., Jandaulyet, J. et al. Clinical and functional impact of central sensitization on patients with familial Mediterranean fever: a cross-sectional study. Rheumatol Int 43, 125–136 (2023). https://doi.org/10.1007/s00296-022-05181-6

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