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Investigation of the human FCRL1, 2, and 4 gene expressions in patients with rheumatoid arthritis

  • Genes and Disease
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Abstract

The Fc receptor-like (FCRL) molecules have recently been shown to contribute to the pathogenesis of certain autoimmune disorders. In this study, we investigated the expression levels of FCRL1, 2 and 4 in blood mononuclear cells from rheumatoid arthritis patients using real-time PCR. The mRNA of these molecules was detected in 44.4 % (FCRL1), 53.3 % (FCRL2) and 31.1 % (FCRL4) of patients. Comparatively, 31.1 % (FCRL1), 51.1 % (FCRL2) and 26.6 % (FCRL4) of controls expressed these genes. Analysis of gene expressions in FCRL-positive patients demonstrated a lower FCRL4 gene expression in patients compared to controls (P < 0.001). In FCRL2-positive patients, a significant positive correlation between FCRL2 expression and the erythrocyte sedimentation rate (P < 0.001), anti-cyclic citrullinated peptide antibody (P = 0.033) level and disease activity score (DAS28, P = 0.016) was found. In conclusion, decreased FCRL4 expression and association of FCRL2 expression with inflammatory markers and disease activity suggested the contribution of these molecules to RA inflammatory processes.

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Acknowledgments

The present article was extracted from the thesis written by one of the authors A. Khanzadeh and was supported by Grant No 6860 from Shiraz University of Medical Sciences.

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Authors and Affiliations

  1. Immunology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Ali Khanzadeh & Zahra Amirghofran

  2. Rheumatology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Zahra Habibagahi

  3. Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran

    Ahmad Hosseini

  4. Department of Immunology, Autoimmune Disease Research Center and Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Zahra Amirghofran

Authors
  1. Ali Khanzadeh
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  2. Zahra Habibagahi
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  3. Ahmad Hosseini
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  4. Zahra Amirghofran
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Correspondence to Zahra Amirghofran.

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Conflicts of interest

Ali Khanzadeh, Zahra Habibagahi, Ahmad Hosseini and Zahra Amirghofran declare that they have no conflict of interest in the authorship or publication of this contribution.

Human and animal rights

This article does not contain any studies with animals performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Khanzadeh, A., Habibagahi, Z., Hosseini, A. et al. Investigation of the human FCRL1, 2, and 4 gene expressions in patients with rheumatoid arthritis. Rheumatol Int 36, 1149–1156 (2016). https://doi.org/10.1007/s00296-016-3495-2

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  • DOI: https://doi.org/10.1007/s00296-016-3495-2

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