Abstract
Peroxisomes are highly dynamic organelles present in most eukaryotic cells. They also play an important role in human health and the optimum functioning of cells. An extensive repertoire of proteins is associated with the biogenesis and function of these organelles. Two protein families that are involved in regulating peroxisome number in a cell directly or indirectly are Pex11 and Pex30. Interestingly, these proteins are also reported to regulate the contact sites between peroxisomes and other cell organelles such as mitochondria, endoplasmic reticulum and lipid droplets. In this manuscript, we review our current knowledge of the role of these proteins in peroxisome biogenesis in various yeast species. Further, we also discuss in detail the role of these protein families in the regulation of inter-organelle contacts in yeast.
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This work was supported by the Department of Biotechnology (DBT), Government of India [BT/PR25097/NER/95/1013/2017], and Top-up of Start-Up grant from IIT Guwahati.
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NMD performed the literature review, wrote the first draft of the manuscript and prepared the figures. SN conceived the idea, edited the manuscript and procured funding. All authors read and approved the final manuscript.
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Deori, N.M., Nagotu, S. Peroxisome biogenesis and inter-organelle communication: an indispensable role for Pex11 and Pex30 family proteins in yeast. Curr Genet 68, 537–550 (2022). https://doi.org/10.1007/s00294-022-01254-y
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DOI: https://doi.org/10.1007/s00294-022-01254-y