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Heme oxygenase 1 in erythropoiesis: an important regulator beyond catalyzing heme catabolism

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Abstract

Heme oxygenase 1 (HO-1), encoded by the HMOX-1 gene, is the main heme oxygenase that catalyzes the degradation of heme into iron, carbon monoxide, and biliverdin. HMOX-1 gene expression is stimulated by oxidative stress and regulated at transcriptional and post-transcriptional levels. After translation, subcellular location and protein stability of HO-1 are also altered by different extracellular and intracellular stimuli. HO-1 plays a key role in regulating iron homeostasis and cell protection and has become a new target for disease treatment. Erythropoiesis is a tightly controlled, iron-dependent process that begins with hematopoietic stem cells and maturates to red blood cells. HO-1 is expressed in hematopoietic stem/progenitor cells, hematopoietic niche cells, erythroblasts, and especially erythroblastic island and phagocytic macrophages. HO-1 functions importantly in the entire erythroid development process by influencing hematopoietic stem cell proliferation, erythroid lineage engagement, terminal erythroid differentiation, and even senescent RBC erythrophagocytosis. HO-1 is also related to stress erythropoiesis and certain red blood cell diseases. Elucidation of HO-1 regulation and function in erythropoiesis will be of great significance for the treatment of related diseases.

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Funding

This work was supported by the grants from Key Research and Development Program of Hunan Province (CN, 2022SK2037), and Natural Science Foundation of Hunan Province (CN, 2021JJ30892).

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  1. Rui Liu and Xuzhi Zhang contributed equally to this work.

Authors and Affiliations

  1. Molecular Biology Research Center, School of Life Sciences; Hunan Province Key Laboratory of Basic and Applied Hematology, Central South University, Changsha, Hunan Province, 410078, People’s Republic of China

    Rui Liu, Xuzhi Zhang, Shuming Sun, Jing Liu & Huiyong Chen

  2. Xiangya School of Medicine, Central South University, Changsha, Hunan Province, 410013, People’s Republic of China

    Xuzhi Zhang

  3. Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, People’s Republic of China

    Ling Nie

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  1. Rui Liu
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Liu, R., Zhang, X., Nie, L. et al. Heme oxygenase 1 in erythropoiesis: an important regulator beyond catalyzing heme catabolism. Ann Hematol 102, 1323–1332 (2023). https://doi.org/10.1007/s00277-023-05193-7

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