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Is C-11 Methionine PET/CT Able to Localise Sestamibi-Negative Parathyroid Adenomas?

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Abstract

Background

Patients with primary hyperparathyroidism (pHPT) and a negative preoperative Tc-99 sestamibi (MIBI) scintigraphy are considered to have a higher risk of persistent disease. The aim of this study was to assess whether additional imaging with C-11 methionine positron emission tomography/computed tomography (Met-PET/CT) is able to localise sestamibi-negative hyperfunctioning parathyroid glands.

Methods

In 50 patients (38 females, 12 males, age 13–81 years) with pHPT and negative localisation procedures such as ultrasound and sestamibi, a Met-PET/CT was performed before parathyroid surgery. The results of Met-PET/CT were analysed prospectively and compared with intraoperative and histopathological findings. 22% of the patients underwent previous parathyroid and/or thyroid surgery.

Results

Met-PET/CT correctly located a single-gland adenoma in 33 of 45 (73%) patients with pHPT. In 5 patients with multiglandular disease, Met-PET/CT detected at least one hyperfunctional parathyroid gland in 4 patients (80%). In 3 patients with double adenomas, 5 of 6 parathyroids were correctly located. Overall, 40 of 57 (70%) hyperfunctioning glands were identified with Met-PET/CT. Met-PET/CT was false-negative in 12 of 50 (24%) patients and false-positive in only one case (2%). Postoperatively, 48 of 50 patients (96%) were cured.

Conclusions

Additional pre-interventional imaging with Met-PET/CT was able to identify hyperfunctioning parathyroid glands in 74% of patients with pHPT and negative sestamibi scans, thus enabling successful parathyroid surgery.

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Authors and Affiliations

  1. Department of Endocrine Surgery, Katholisches Klinikum Mainz, An der Goldgrube 11, 55131, Mainz, Germany

    Theresia Weber

  2. Department of Nuclear Medicine, University Medical Center Ulm, Ulm, Germany

    Martin Gottstein, Sabrina Schwenzer & Ambros Beer

  3. Department of Nuclear Medicine, University of Marburg, Marburg, Germany

    Markus Luster

Authors
  1. Theresia Weber
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  2. Martin Gottstein
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  3. Sabrina Schwenzer
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  4. Ambros Beer
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  5. Markus Luster
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Correspondence to Theresia Weber.

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Weber, T., Gottstein, M., Schwenzer, S. et al. Is C-11 Methionine PET/CT Able to Localise Sestamibi-Negative Parathyroid Adenomas?. World J Surg 41, 980–985 (2017). https://doi.org/10.1007/s00268-016-3795-4

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  • DOI: https://doi.org/10.1007/s00268-016-3795-4

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