Abstract
Background
Near-infrared II theranostic agents have gained great momentum in the research field of AD owing to the appealing advantages. Recently, an array of activatable NIR-II fluorescence probes has been developed to specifically monitor pathological targets of AD. Furthermore, various NIR-II-mediated nanomaterials with desirable photothermal and photodynamic properties have demonstrated favorable outcomes in the management of AD.
Methods
We summerized amounts of references and focused on small-molecule probes, nanomaterials, photothermal therapy, and photodynamic therapy based on NIR-II fluorescent imaging for the diagnosis and treatment in AD. In addition, design strategies for NIR-II-triggered theranostics targeting AD are presented, and some prospects are also addressed.
Results
NIR-II theranostic agents including small molecular probes and nanoparticles have received the increasing attention for biomedical applications. Meanwhile, most of the theranostic agents exhibited the promising results in animal studies. To our surprise, the multifunctional nanoplatforms also show a great potential in the diagnosis and treatment of AD.
Conclusions
Although NIR-II theranostic agents showed the great potential in diagnosis and treatment of AD, there are still many challenges: 1) Faborable NIR-II fluorohpores are still lacking; 2) Biocompatibility, bioseurity and dosage of NIR-II theranostic agents should be further revealed; 3) New equipment and software associated with NIR-II imaging system should be explored.
Graphical Abstract
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Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.
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This work is supported by the National Natural Science Foundation of China (No.81971677) and Shanghai Natural Science Foundation (No.22ZR1424400).
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Xiao Li, Xingdang Liu, and Jian Yang had the idea for the article. Screening and selection of the literatures were performed by Can Zhou, Fantian Zeng, and Jian Yang. The first draft of the manuscript was written by Can Zhou, Fantian Zeng, and Jian Yang; all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Zhou, C., Zeng, F., Yang, H. et al. Near-infrared II theranostic agents for the diagnosis and treatment of Alzheimer’s disease. Eur J Nucl Med Mol Imaging (2024). https://doi.org/10.1007/s00259-024-06690-1
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DOI: https://doi.org/10.1007/s00259-024-06690-1