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Update of pediatric bone tumors—other mesenchymal tumors of bone, hematopoietic neoplasms of bone, and WHO classification of undifferentiated small round cell sarcomas of bone

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Abstract

There are numerous bone tumors in the pediatric population, with imaging playing an essential role in diagnosis and management. Our understanding of certain bone tumors has rapidly evolved over the past decade with advancements in next-generation genetic sequencing techniques. This increased level of understanding has altered the nomenclature, management approach, and prognosis of certain lesions. We provide a detailed update of bone tumors that occur in the pediatric population with emphasis on the recently released nomenclature provided in the 5th edition of the World Health Organization Classification of Soft Tissue and Bone Tumours. We discuss other mesenchymal tumors of bone, hematopoietic neoplasms of bone, and WHO classification of undifferentiated small round cell sarcomas of bone. We have detailed osteogenic tumors and osteoclastic giant cell-rich tumors, as well as notochordal tumors, chondrogenic tumors, and vascular tumors of the bone in separate manuscripts.

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Author information

Authors and Affiliations

  1. Yale Radiology and Biomedical Imaging, 330 Cedar Street, New Haven, CT, 06520, USA

    Annie Wang, Andrew Haims & Jack Porrino

  2. Seattle Children’s Hospital, 4800 Sand Point Way NE, Seattle, WA, 98105, USA

    Ezekiel Maloney & Atif Ahmed

  3. Boston Children’s Hospital, 300 Longwood Ave, Boston, MA, 02115, USA

    Khalid Al-Dasuqi

  4. Pathology Associates at Beverly Hospital, 85 Herrick Street, Beverly, MA, 01915, USA

    Lina Irshaid

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  1. Annie Wang
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Correspondence to Jack Porrino.

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Wang, A., Maloney, E., Al-Dasuqi, K. et al. Update of pediatric bone tumors—other mesenchymal tumors of bone, hematopoietic neoplasms of bone, and WHO classification of undifferentiated small round cell sarcomas of bone. Skeletal Radiol 52, 1443–1463 (2023). https://doi.org/10.1007/s00256-023-04286-8

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