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Assessment of the zonal variation of perfusion parameters in the femoral head: a 3-T dynamic contrast-enhanced MRI pilot study

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Abstract

Objective

The objective was to describe MR perfusion characteristics of the femoral head, with a focus on the subchondral bone.

Materials and methods

This prospective monocentric study was approved by our local Ethics Committee. Written informed consent was obtained from all subjects. Dynamic contrast-enhanced MRI of the right hip was performed in 59 adults with suspected spondyloarthritis (32 women, 28 men). Mean age was 37.5 (±12.5) years. Regions of interest were drawn in the femoral head epiphysis, in the subchondral areas the most exposed to mechanical load (superolateral, anterosuperior, and posterior zones) and in areas less exposed to mechanical load (inferior subchondral zone and center of the femoral head). Semi-quantitative and pharmacokinetic parameters were calculated using the Tofts model. Statistical analysis was performed with a linear mixed model to compare the perfusion parameters in the different femoral head zones.

Results

Extravascular extracellular volume and area under the curve were lower in the superolateral zone than in the inferior zone (p = 0.0135 and p < 0.0001 respectively) and the central zone (p = 0.007 and p = 0.0134 respectively). Extravascular extracellular volume and rate constant were lower in the anterosuperior zone than in the inferior zones (p = 0.011 and p = 0.029). In the anterosuperior zone, extravascular extracellular volume was lower, and time to peak was higher than in the central zones (p = 0.0056 and p = 0.0013 respectively). No significant differences were found for any values between other paired zones.

Conclusion

The perfusion of femoral head subchondral bone assessed with dynamic contrast-enhanced magnetic resonance imaging is not homogeneous: the areas exposed to more mechanical loading are less perfused.

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Acknowledgements

The authors would like to thank Mr Julien Labreuche from the Biostatistics department of Lille Regional University Hospital (Lille, France) for his contribution in the statistical analysis.

No specific grant was received for this research from funding agencies in the public, commercial, or not-for-profit sectors.

Funding

The authors did not benefit from any grants or funding.

Author information

Authors and Affiliations

  1. Imaging Department, Lille Catholic Hospitals, Lille Catholic University, F-59000, Lille, France

    Jean-François Budzik & Sébastien Verclytte

  2. Lille University, Littoral Côte d’Opale University, EA 4490, PMOI, Physiopathologie des Maladies Osseuses Inflammatoires, F-59000, Lille, France

    Jean-François Budzik & Anne Cotten

  3. Musculoskeletal Imaging Department, Centre de Consultation et d’Imagerie de l’Appareil Locomoteur, CHU Lille, University of Lille Nord de France, F-59000, Lille, France

    Guillaume Lefebvre & Anne Cotten

  4. Biostatistics Department, Lille Regional University Hospital, University of Lille Nord de France, F-59000, Lille, France

    Hélène Behal

  5. Littoral Côte d’Opale University, Lille University, EA 4490, PMOI, Physiopathologie des Maladies Osseuses Inflammatoires, F-59000, Lille, France

    Pierre Hardouin

  6. Service d’Imagerie Guilloz, Hôpital Central, Centre Hospitalier Universitaire de Nancy, 29 Ave du Maréchal de Lattre de Tassigny, F-54035, Nancy, France

    Pedro Teixeira

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  1. Jean-François Budzik
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  2. Guillaume Lefebvre
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  3. Hélène Behal
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  4. Sébastien Verclytte
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  5. Pierre Hardouin
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  6. Pedro Teixeira
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  7. Anne Cotten
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Corresponding author

Correspondence to Jean-François Budzik.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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The authors declare that they have no conflicts of interest.

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Budzik, JF., Lefebvre, G., Behal, H. et al. Assessment of the zonal variation of perfusion parameters in the femoral head: a 3-T dynamic contrast-enhanced MRI pilot study. Skeletal Radiol 47, 261–270 (2018). https://doi.org/10.1007/s00256-017-2802-7

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  • DOI: https://doi.org/10.1007/s00256-017-2802-7

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