Abstract
Ganglia are benign soft tissue masses that are found adjacent to joints and tendons. They can be multifocal but they are rarely more numerous than a few around any given joint. “Cystic ganglionosis” has been used to describe a condition in which multifocal and extensive ganglia are present. We present a rare case of cystic ganglionosis in a Caucasian girl with clinical symptoms detected at 6 months of age. To the authors’ knowledge, only a single other case report of cystic ganglionosis is documented in the English medical literature. The ganglia in this case are more extensive, manifested at an earlier age and caused erosions of multiple bones, a rarely observed complication of ganglia. Additionally, radiograph, MR and sonographic images collected over 9 years time allows for a detailed description of the imaging characteristics of this case of cystic ganglionosis, and offers unique insight into the natural history of this diagnosis. Extensive ganglia in multiple locations in a young child should alert clinicians to the possibility of cystic ganglionosis. Disease progression may lead to deleterious effects on bone warranting the use of maintenance imaging and possibly surgical resection of symptomatic lesions.
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Kransdorf M, Murphey M. In: Pine Jr J, editor. Imaging of soft tissue tumors. 3rd ed. Philadelphia: Lippincott Williams and Wilkins; 2014.
Meena S, Gupta A. Dorsal wrist ganglion: current review of literature. J Clin Orthop Trauma [Internet]. 2014;5(2):59–64. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0976566214000319
Angelides AC, Wallace PF. The dorsal ganglion of the wrist: its pathogenesis, gross and microscopic anatomy, and surgical treatment. J Hand Surg [Am]. 1976;1(3):228–35. doi:10.1016/S0363-5023(76)80042-1.
Lowden CM, Attiah M, Garvin G, MacDermid JC, Osman S, Faber KJ. The prevalence of wrist ganglia in an asymptomatic population: magnetic resonance evaluation. J Hand Surg [Am]. 2005;30(3):302–6.
Satku K, Ganesh B. Ganglia in children. J Pediatr Orthop. 1985. Jan–Feb;5(1):13–5.
Nelson CL, Sawmiller S, Phalen GS. Ganglions of the wrist and hand. J Bone Joint Surg Am. 1972;54(7):1459–64.
Paivansalo M, Jalovaara P. Ultrasound findings of ganglions of the wrist. Eur J Radiol. 1991;13(3):178–80.
Latif A, Ansar A, Butt MQ. Treatment of ganglions: a five year experience. J Pak Med Assoc [Internet]. 2014;64(11):1278–81. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25831646. Accessed November 2015.
Teefey SA, Dahiya N, Middleton WD, Gelberman RH, Boyer MI. Ganglia of the hand and wrist: a sonographic analysis. Am J Roentgenol. 2008;191(3):716–20.
MacKinnon AE, Azmy A. Active treatment of ganglia in children. Postgrad Med J. 1977;53(621):378–81.
Bracken J, Bartlett M. Ganglion cysts in the paediatric wrist: magnetic resonance imaging findings. Pediatr Radiol. 2013;43(12):1622–8.
Coffey MJ, Fazlur Rahman M, Thirkannad SM. Pediatric ganglion cysts of the hand and wrist: an epidemiologic analysis. Hand. 2008;3(4):359–62.
Shinawi M, Hicks J, Guillerman RP, et al. Multiple ganglion cysts (‘cystic ganglionosis’): an unusual presentation in a child. Scand J Rheumatol. 2007;36(2):145–8.
Stocker JT, Dehner LP, Husain AN. Stocker and Dehner’s pediatric pathology. 3rd ed. Philadelphia: Wolters Kluwer Health; 2012. 1255 p.
Bauer JS, Müller D, Sauerschnig M, et al. Ganglia of the tarsal sinus: MR imaging features and clinical findings. Eur J Radiol. 2011;80(3):394–400.
O’Valle F, Hernández-Cortés P, Aneiros-Fernández J, et al. Morphological and immunohistochemical evaluation of ganglion cysts. cross-sectional study of 354 cases. Histol Histopathol. 2014;29(5):601–7.
Psaila JV, Mansel RE. The surface ultrastructure of ganglia. J Bone Joint Surg (Br). 1978;60-B(2):228–33.
Giard M-C, Pineda C. Ganglion cyst versus synovial cyst? Ultrasound characteristics through a review of the literature. Rheumatol Int. 2014;35(4):597–605. doi:10.1007/s00296-014-3120-1.
Soren A. Pathogenesis, clinic, and treatment of ganglion. Arch Orthop Trauma Surg. 1982;99(4):247–52.
Angelides A. Ganglions of the hand and wrist. In: Green D, Hotchkiss R, Pederson W, editors. Green’s operative hand surgery. 5th ed. New York: Churchill Livingstone; 1999. p. 2171–83.
Colon F, Upton J. Pediatric hand tumors: a review of 349 cases. Hand Clin. 1995;11(2):223–43.
Nahra ME, Bucchieri JS. Ganglion cysts and other tumor related conditions of the hand and wrist. Hand Clinics; 2004. p. 249–60.
De Flaviis L, Nessi R, Del Bo P, Calori G, Balconi G. High-resolution ultrasonography of wrist ganglia. J Clin Ultrasound. 1987;15(1):17–22.
Wang G, Jacobson JA, Feng FY, Girish G, Caoili EM, Brandon C. Sonography of wrist ganglion cysts: variable and noncystic appearances. J Ultrasound Med. 2007;26(10):1323–8.
MacCollum MS. Dorsal wrist ganglions in children. J Hand Surg [Am]. 1977;2(4):325. doi:10.1016/S0363-5023(77)80137-8.
Rosson JW, Walker G. The natural history of ganglia in children. J Bone Joint Surg (Br). 1989;71(4):707–8.
Calif E, Stahl S, Stahl S. Simple wrist ganglia in children: a follow-up study. J Pediatr Orthop B. 2005;14(6):448–50.
Castellanos J, Bertrán C, Pérez R, Roca J. Pathologic fracture of the scaphoid caused by intraosseous ganglion followed by regression after the healing of the fracture. J Trauma. 2001;51(1):141–3.
Tudisco C, Bisicchia S. Intraosseous ganglion with impending fracture of the glenoid. Orthopedics. 2011;956–9.
Sakamoto A, Oda Y, Iwamoto Y. Intraosseous ganglia: a series of 17 treated cases. Biomed Res Int. 2013;2013:3–6.
Murata K, Nakagawa Y, Suzuki T, Kobayashi M, Kotani S, Nakamura T. Intraosseous ganglion about to cause a fracture of the glenoid: a case report. Knee Surg Sports Traumatol Arthrosc. 2007;15(10):1261–3.
Jain D, Selhi HS, Yamin M. Lymphangioma presenting as juxta-articular swelling in children: a case series. APSP J Case Rep. 2013;4(2):30.
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Meyer, N.P., Meyers, A.B., Szabo, S. et al. A rare case of cystic ganglionosis in a child with associated imaging findings. Skeletal Radiol 45, 419–426 (2016). https://doi.org/10.1007/s00256-015-2294-2
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DOI: https://doi.org/10.1007/s00256-015-2294-2