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Woodfordia fruticosa (L.) Kurz: in vitro biotechnological interventions and perspectives

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Abstract

Woodfordia fruticosa (L.) Kurz is a woody medicinal shrub (Lythraceae) commonly known as the “fire flame bush.” W. fruticosa plant parts either alone or whole plant have a long history of recommended use in the Indian medicine systems of Ayurveda, Unani, and Siddha (AUS). This plant is prominently known for its pharmacological properties, viz., antimicrobial, anti-inflammatory, anti-peptic ulcer, hepatoprotective, immunomodulatory, antitumor, cardioprotective, analgesic, and wound healing activities. Its important phyto-constituents, woodfordin C, woodfordin I, oenothein B, and isoschimacoalin-A, exhibit in vitro or in vivo physiological activities beneficial to human health. As the plant is a rich storehouse of phyto-constituents, it is indiscriminately used in its wild habitats. Moreover, due to very poor seed viability and difficult-to-root qualities, it is placed under IUCN list of endangered plant species. For W. fruticosa, biomass production or to its conservation by in vitro regeneration is the best feasible alternative. Till date, only few important in vitro regeneration methods are reported in W. fruticosa. ISSR molecular markers based clonal fidelity and Agrobacterium-mediated transformation has been demonstrated, indicating that W. fruticosa is amenable to genetic manipulation and genome editing studies. This review presents concise summary of updated reports on W. fruticosa phyto-constituents and their biological activities, while a critical appraisal of biotechnological interventions, shortcomings, and factors influencing such potential areas success was presented. The unexplored gaps addressed here are relevant for W. fruticosa scientific innovations yet to come. In this paper, for the first time, we have presented a simple and reproducible protocol for synthetic seed production in W. fruticosa.

Key points

• Critical and updated records on W. fruticosa phytochemistry and its activities

• In vitro propagation and elicitation of secondary metabolites in W. fruticosa

• Key bottlenecks, in vitro flowering, value addition, and outlook in W. fruticosa

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Data availability

All data supporting the findings of this study are available within the paper and also available from the corresponding author upon reasonable request.

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Acknowledgements

RNM, BK, BB, MM, SVSR, SRT, and MA are grateful to the Department of Biotechnology, Telangana University, Nizamabad, India, for providing the facilities.

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Author notes

  1. Mallesham Bulle

    Present address: Institute of Genomics for Crop Abiotic Stress Tolerance, Department of Plant and Soil Science, Texas Tech University, Lubbock, TX, USA

  2. Mahender Aileni and Mallesham Bulle contributed equally to this work.

Authors and Affiliations

  1. Department of Biotechnology, Telangana University, Dichpally, Nizamabad, Telangana, 503322, India

    Mahender Aileni, Ramesh Naik Malavath, Satyamraj Thurpu, Kiranmayi Bandaram, Bhargavi Balkampeta, Meghana Marri & Vijaya Simha Reddy Singasani

  2. Agri Biotech Foundation, Agricultural University Campus, Rajendranagar, Hyderabad, 500030, Telangana, India

    Mallesham Bulle

  3. Department of Botany, Satavahana University, Karimnagar, India

    E. N. Murthy

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  1. Mahender Aileni
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Contributions

All authors made substantial contributions to conception, design, acquisition of literature, and its interpretation in drafting the article. Writing the draft, its review, and editing were performed by MB, MA, and ENM. RNM, BK, BB, MM, SVSR, and SRT conducted technical experiments and helped in making the tables. All authors read and approved the final manuscript.

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Correspondence to Mahender Aileni or Mallesham Bulle.

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Aileni, M., Bulle, M., Malavath, R.N. et al. Woodfordia fruticosa (L.) Kurz: in vitro biotechnological interventions and perspectives. Appl Microbiol Biotechnol 107, 5855–5871 (2023). https://doi.org/10.1007/s00253-023-12695-x

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