Abstract
Zearalenone (ZEN) and its derivatives are one of the most contaminated fungal toxins worldwide, posing a severe threat to food security and human life. Traditional physical and chemical detoxifying methods are unsatisfactory due to incomplete detoxification, nutrient loss, and secondary pollutants. In recent years, bioremediation for eliminating fungal toxins has been gradually investigated. ZEN lactone hydrolase (lactonase) has been widely studied because of its high activity, mild conditions, and non-toxic product property. This review comprehensively represents the gene mining, characterization, molecular modification, and application of microbial-derived ZEN lactonases. It is aimed to elucidate the advantages and challenges of ZEN lactonases in industrial application, which also provides perspectives on obtaining innovative and promising biocatalysts for ZEN degradation.
Key points
• A timely and concise review related to enzymatic elimination towards ZEN is shown.
• The catalytic conditions and mechanism of ZEN lactonase is presented.
• The modification and application of ZEN lactonase are exhibited also.
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This work was supported by the National Key R&D Program of China (2019YFC1604602).
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Y. Y. Fang: data analysis, writing — original draft. Z. X. Zhang: writing — original draft. W. Xu: writing — review and editing. W. L. Zhang: methodology. C. E. Guang: supervision. W. M. Mu: supervision, project administration.
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Fang, Y., Zhang, Z., Xu, W. et al. Zearalenone lactonase: characteristics, modification, and application. Appl Microbiol Biotechnol 106, 6877–6886 (2022). https://doi.org/10.1007/s00253-022-12205-5
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DOI: https://doi.org/10.1007/s00253-022-12205-5