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Partial voxel interpolation to reduce partial volume error of cardiac computed tomography ventricular volumetry in patients with congenital heart disease

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Abstract

Background

Varying degrees of partial volume error depending on the complexity of the endocardial borders are inevitable in threshold-based cardiac computed tomography (CT) ventricular volumetry. These errors can potentially be reduced by using a partial voxel interpolation (PVI) method, but this has not been tested for cardiac CT ventricular volumetry.

Objective

To evaluate the partial volume error-reducing effects of the PVI method in cardiac CT ventricular volumetry among patients with congenital heart disease (CHD).

Materials and methods

The cardiac CT ventricular volumetry data were obtained from 55 patients (median age 12.0 years) with CHD. The ventricular and myocardial volumes, ejection fraction and ventricular mass-volume ratio were quantified and compared before and after the PVI method. The correlation between the myocardial volumes in the end-systolic and end-diastolic phases was tested. The effect of the PVI method on the classification of ventricular hypertrophy was evaluated.

Results

The indexed ventricular volumes after PVI were significantly smaller (7.4–11.5%) than those before PVI (P<0.001). In contrast, the indexed myocardial volumes were significantly larger (6.2–27.7%) after PVI (P<0.001). The ejection fractions and mass-volume ratios were significantly larger (1.6–2.2% and 19.7–42.5%, respectively) after PVI (P<0.001 and P<0.001, respectively). The indexed myocardial masses showed prominently high correlation between the end-systolic and end-diastolic phases (R, 0.961–0.990; P<0.001). The proportions of no and severe hypertrophy were significantly decreased (P<0.002) and increased (P<0.032), respectively, after the application of the PVI method.

Conclusion

The PVI method can reduce partial volume error in cardiac CT ventricular volumetry among patients with CHD.

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Data availability

Data will be available on reasonable request.

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Acknowledgements

We would like to thank Ms. Seon Young Goo for correcting the English language.

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Authors and Affiliations

  1. Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea

    Hyun Woo Goo & Sang Hyub Park

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  1. Hyun Woo Goo
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All authors whose names appear on the submission (1) made substantial contributions to the conception or design of the work; or the acquisition, analysis or interpretation of data, (2) drafted the work or revised it critically for important intellectual content, (3) approved the version to be published and (4) agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Correspondence to Hyun Woo Goo.

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Goo, H.W., Park, S.H. Partial voxel interpolation to reduce partial volume error of cardiac computed tomography ventricular volumetry in patients with congenital heart disease. Pediatr Radiol 53, 2528–2538 (2023). https://doi.org/10.1007/s00247-023-05734-2

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  • DOI: https://doi.org/10.1007/s00247-023-05734-2

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