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Review of diffusion tensor imaging and its application in children

  • Advances in Pediatric Neuroradiology
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Abstract

Diffusion MRI is an imaging technique that uses the random motion of water to probe tissue microstructure. Diffusion tensor imaging (DTI) can quantitatively depict the organization and connectivity of white matter. Given the non-invasiveness of the technique, DTI has become a widely used tool for researchers and clinicians to examine the white matter of children. This review covers the basics of diffusion-weighted imaging and diffusion tensor imaging and discusses examples of their clinical application in children.

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References

  1. Yang E, Nucifora PG, Melhem ER (2011) Diffusion MR imaging: basic principles. Neuroimaging Clin N Am 21:1–25

    Article  CAS  PubMed  Google Scholar 

  2. Einstein A (1905) On the movement of small particles suspended in stationary liquids required by the molecular-kinetic theory of heat. Ann Phys 17:549–560

  3. Basser PJ, Mattiello J, LeBihan D (1994) Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B 103:247–254

    Article  CAS  PubMed  Google Scholar 

  4. Huisman TA (2010) Diffusion-weighted and diffusion tensor imaging of the brain, made easy. Cancer Imaging 10A:S163–S171

    Article  Google Scholar 

  5. Moseley ME, Cohen Y, Mintorovitch J et al (1990) Early detection of regional cerebral ischemia in cats: comparison of diffusion- and T2-weighted MRI and spectroscopy. Magn Reson Med 14:330–346

    Article  CAS  PubMed  Google Scholar 

  6. Tanner JE, Stejskal EO (1968) Restricted self-diffusion of protons in colloidal systems by the pulsed-gradient, spin-echo method. J Chem Phys 49:1768–1777

    Article  CAS  Google Scholar 

  7. Mori S, Tournier JD (2014) Introduction to diffusion tensor imaging and higher order models. Elsevier/Academic Press, Amsterdam Boston

    Google Scholar 

  8. Mukherjee P, Berman JI, Chung SW et al (2008) Diffusion tensor MR imaging and fiber tractography: theoretic underpinnings. AJNR Am J Neuroradiol 29:632–641

    Article  CAS  PubMed  Google Scholar 

  9. Beaulieu C (2002) The basis of anisotropic water diffusion in the nervous system — a technical review. NMR Biomed 15:435–455

    Article  PubMed  Google Scholar 

  10. Choudhri AF, Chin EM, Blitz AM et al (2014) Diffusion tensor imaging of cerebral white matter: technique, anatomy, and pathologic patterns. Radiol Clin N Am 52:413–425

    Article  PubMed  Google Scholar 

  11. Basser PJ, Mattiello J, LeBihan D (1994) MR diffusion tensor spectroscopy and imaging. Biophys J 66:259–267

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Mukherjee P, Chung SW, Berman JI et al (2008) Diffusion tensor MR imaging and fiber tractography: technical considerations. AJNR Am J Neuroradiol 29:843–852

  13. Wimberger DM, Roberts TP, Barkovich AJ et al (1995) Identification of ‘premyelination’ by diffusion-weighted MRI. J Comput Assist Tomogr 19:28–33

    Article  CAS  PubMed  Google Scholar 

  14. Counsell SJ, Maalouf EF, Fletcher AM et al (2002) MR imaging assessment of myelination in the very preterm brain. AJNR Am J Neuroradiol 23:872–881

    PubMed  Google Scholar 

  15. Garel C, Chantrel E, Elmaleh M et al (2003) Fetal MRI: normal gestational landmarks for cerebral biometry, gyration and myelination. Childs Nerv Syst 19:422–425

    Article  PubMed  Google Scholar 

  16. Welker KM, Patton A (2012) Assessment of normal myelination with magnetic resonance imaging. Semin Neurol 32:15–28

    Article  PubMed  Google Scholar 

  17. Oishi K, Faria AV, Yoshida S et al (2013) Quantitative evaluation of brain development using anatomical MRI and diffusion tensor imaging. Int J Dev Neurosci 31:512–524

    Article  PubMed  Google Scholar 

  18. Yoshida S, Oishi K, Faria AV et al (2013) Diffusion tensor imaging of normal brain development. Pediatr Radiol 43:15–27

    Article  PubMed Central  PubMed  Google Scholar 

  19. Mukherjee P, Miller JH, Shimony JS et al (2001) Normal brain maturation during childhood: developmental trends characterized with diffusion-tensor MR imaging. Radiology 221:349–358

    Article  CAS  PubMed  Google Scholar 

  20. Partridge SC, Mukherjee P, Henry RG et al (2004) Diffusion tensor imaging: serial quantitation of white matter tract maturity in premature newborns. Neuroimage 22:1302–1314

    Article  PubMed  Google Scholar 

  21. Hermoye L, Saint-Martin C, Cosnard G et al (2006) Pediatric diffusion tensor imaging: normal database and observation of the white matter maturation in early childhood. Neuroimage 29:493–504

    Article  PubMed  Google Scholar 

  22. Eluvathingal TJ, Hasan KM, Kramer L et al (2007) Quantitative diffusion tensor tractography of association and projection fibers in normally developing children and adolescents. Cereb Cortex 17:2760–2768

    Article  PubMed Central  PubMed  Google Scholar 

  23. Giorgio A, Watkins KE, Douaud G et al (2008) Changes in white matter microstructure during adolescence. Neuroimage 39:52–61

    Article  CAS  PubMed  Google Scholar 

  24. Wu M, Lu LH, Lowes A et al (2014) Development of superficial white matter and its structural interplay with cortical gray matter in children and adolescents. Hum Brain Mapp 35:2806–2816

    Article  PubMed  Google Scholar 

  25. Chokshi FH, Poretti A, Meoded A et al (2011) Normal and abnormal development of the cerebellum and brainstem as depicted by diffusion tensor imaging. Semin Ultrasound CT MR 32:539–554

    Article  PubMed  Google Scholar 

  26. Lee SK, Kim DI, Kim J et al (2005) Diffusion-tensor MR imaging and fiber tractography: a new method of describing aberrant fiber connections in developmental CNS anomalies. Radiographics 25:53–65, discussion 66–68

    Article  PubMed  Google Scholar 

  27. Poretti A, Meoded A, Rossi A et al (2013) Diffusion tensor imaging and fiber tractography in brain malformations. Pediatr Radiol 43:28–54

    Article  PubMed  Google Scholar 

  28. Rollins NK (2007) Clinical applications of diffusion tensor imaging and tractography in children. Pediatr Radiol 37:769–780

    Article  PubMed  Google Scholar 

  29. Wahl M, Barkovich AJ, Mukherjee P (2010) Diffusion imaging and tractography of congenital brain malformations. Pediatr Radiol 40:59–67

    Article  PubMed Central  PubMed  Google Scholar 

  30. Barkovich AJ, Raybaud C (2012) Pediatric neuroimaging. Lippincott, Williams & Wilkins/Wolters Kluwer Health, Philadelphia

    Google Scholar 

  31. Lee SK, Mori S, Kim DJ et al (2004) Diffusion tensor MR imaging visualizes the altered hemispheric fiber connection in callosal dysgenesis. AJNR Am J Neuroradiol 25:25–28

    CAS  PubMed  Google Scholar 

  32. Nakata Y, Barkovich AJ, Wahl M et al (2009) Diffusion abnormalities and reduced volume of the ventral cingulum bundle in agenesis of the corpus callosum: a 3T imaging study. AJNR Am J Neuroradiol 30:1142–1148

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  33. Tovar-Moll F, Moll J, de Oliveira-Souza R et al (2007) Neuroplasticity in human callosal dysgenesis: a diffusion tensor imaging study. Cereb Cortex 17:531–541

    Article  PubMed  Google Scholar 

  34. Utsunomiya H, Yamashita S, Takano K et al (2006) Arrangement of fiber tracts forming Probst bundle in complete callosal agenesis: report of two cases with an evaluation by diffusion tensor tractography. Acta Radiol 47:1063–1066

    Article  CAS  PubMed  Google Scholar 

  35. Wahl M, Strominger Z, Jeremy RJ et al (2009) Variability of homotopic and heterotopic callosal connectivity in partial agenesis of the corpus callosum: a 3T diffusion tensor imaging and Q-ball tractography study. AJNR Am J Neuroradiol 30:282–289

    Article  CAS  PubMed  Google Scholar 

  36. Aziz ZA, Saini J, Bindu PS et al (2013) Demonstration of different histological layers of the pachygyria/agyria cortex using diffusion tensor MR imaging. Surg Radiol Anat 35:427–433

    Article  PubMed  Google Scholar 

  37. Rollins N, Reyes T, Chia J (2005) Diffusion tensor imaging in lissencephaly. AJNR Am J Neuroradiol 26:1583–1586

    PubMed  Google Scholar 

  38. Kao YC, Peng SS, Weng WC et al (2011) Evaluation of white matter changes in agyria-pachygyria complex using diffusion tensor imaging. J Child Neurol 26:433–439

    Article  PubMed  Google Scholar 

  39. Colombo N, Salamon N, Raybaud C et al (2009) Imaging of malformations of cortical development. Epileptic Disord 11:194–205

    PubMed  Google Scholar 

  40. Kabat J, Krol P (2012) Focal cortical dysplasia — review. Pol J Radiol 77:35–43

    Article  PubMed Central  PubMed  Google Scholar 

  41. Madan N, Grant PE (2009) New directions in clinical imaging of cortical dysplasias. Epilepsia 50:9–18

    Article  PubMed  Google Scholar 

  42. Blumcke I, Thom M, Aronica E et al (2011) The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc task force of the ILAE Diagnostic Methods Commission. Epilepsia 52:158–174

    Article  PubMed Central  PubMed  Google Scholar 

  43. Dumas de la Roque A, Oppenheim C, Chassoux F et al (2005) Diffusion tensor imaging of partial intractable epilepsy. Eur Radiol 15:279–285

    Article  PubMed  Google Scholar 

  44. Eriksson SH, Rugg-Gunn FJ, Symms MR et al (2001) Diffusion tensor imaging in patients with epilepsy and malformations of cortical development. Brain 124:617–626

    Article  CAS  PubMed  Google Scholar 

  45. Gross DW, Bastos A, Beaulieu C (2005) Diffusion tensor imaging abnormalities in focal cortical dysplasia. Can J Neurol Sci 32:477–482

    Article  PubMed  Google Scholar 

  46. Lee SK, Kim DI, Mori S et al (2004) Diffusion tensor MRI visualizes decreased subcortical fiber connectivity in focal cortical dysplasia. Neuroimage 22:1826–1829

    Article  PubMed  Google Scholar 

  47. Widjaja E, Blaser S, Miller E et al (2007) Evaluation of subcortical white matter and deep white matter tracts in malformations of cortical development. Epilepsia 48:1460–1469

    Article  PubMed  Google Scholar 

  48. Chen Q, Lui S, Li CX et al (2008) MRI-negative refractory partial epilepsy: role for diffusion tensor imaging in high field MRI. Epilepsy Res 80:83–89

    Article  PubMed  Google Scholar 

  49. Widjaja E, Zarei Mahmoodabadi S, Otsubo H et al (2009) Subcortical alterations in tissue microstructure adjacent to focal cortical dysplasia: detection at diffusion-tensor MR imaging by using magnetoencephalographic dipole cluster localization. Radiology 251:206–215

    Article  PubMed  Google Scholar 

  50. Diehl B, Tkach J, Piao Z et al (2010) Diffusion tensor imaging in patients with focal epilepsy due to cortical dysplasia in the temporo-occipital region: electro-clinico-pathological correlations. Epilepsy Res 90:178–187

    Article  CAS  PubMed  Google Scholar 

  51. Tuch DS, Reese TG, Wiegell MR et al (2003) Diffusion MRI of complex neural architecture. Neuron 40:885–895

    Article  CAS  PubMed  Google Scholar 

  52. Wedeen VJ, Hagmann P, Tseng W-YI et al (2005) Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging. Magn Res Med 54:1377–1386

    Article  Google Scholar 

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Conflicts of interest

Dr. J. I. Berman receives a consulting fee from McGowan Associates. Dr. G. A. Vorona has no financial interests, investigational or off-label uses to disclose.

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Correspondence to Jeffrey I. Berman.

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Vorona, G.A., Berman, J.I. Review of diffusion tensor imaging and its application in children. Pediatr Radiol 45 (Suppl 3), 375–381 (2015). https://doi.org/10.1007/s00247-015-3277-0

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  • DOI: https://doi.org/10.1007/s00247-015-3277-0

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