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Functional disruptions of the brain network in low back pain: a graph-theoretical study

  • Advanced Neuroimaging
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Abstract

Purpose

The aim of this study was to investigate alterations in the topological organization of whole-brain functional networks in patients with chronic low back pain (CLBP) and characterize the relationship of these alterations with pain characteristics.

Methods

Thirty-three CLBP patients and 34 matched healthy controls (HCs) underwent fMRI scans. A graph-theoretical approach was applied to identify brain network changes in patients suffering from chronic low back pain given its nonspecific etiology and complexity. Graph theory-based analysis was used to construct functional connectivity matrices and extract the features of small-world networks of the brain in both groups. Then, the whole-brain functional connectivity differences were characterized by network-based statistics (NBS) analysis, and the relationship between the altered brain features and clinical measures was explored.

Results

At the global level, patients with CLBP showed significantly decreased gamma, sigma, global efficiency, and local efficiency and increased lambda and shortest path length compared with HCs. At the regional level, there were deficits in nodal efficiency within the default mode network and salience network. NBS analysis demonstrated that decreased functional connectivity was present in the CLBP patients, mainly in the frontolimbic circuit and temporal regions. Furthermore, aspects of topological dysfunctions in CLBP were correlated with pain severity.

Conclusion

This study highlighted the aberrant topological organization of functional brain networks in CLBP, which may shed light on the pathophysiology of CLBP and support the development of pain management approaches.

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Acknowledgements

The authors thank all the participants for their participation in the study.

Funding

This work was supported by grants from Natural Science Foundation of Shaanxi Province (2022SF-347, 2021SF-147, 2018SF-135), National Natural Science Foundation of China (81501455), and China Scholarship Council (201806285075).

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Authors and Affiliations

  1. Department of Medical Imaging, Second Affiliated Hospital of Xi’an Jiaotong University, 157, Xi’wu Road, Xi’an, 710004, Shaanxi, China

    Hua Juan Yang, Hong Mei Wu, Xiao Hui Li, Rui Jin, Lei Zhang, Ting Dong, Xiao Qian Zhou, Bo Zhang, Qiu Juan Zhang & Cui Ping Mao

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Yang, H.J., Wu, H.M., Li, X.H. et al. Functional disruptions of the brain network in low back pain: a graph-theoretical study. Neuroradiology 65, 1483–1495 (2023). https://doi.org/10.1007/s00234-023-03209-7

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