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The Role of Ferroptosis in the Pathogenesis of Osteoarthritis

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Abstract

Osteoarthritis (OA) is the most common type of arthritis. Its high prevalence, especially in the elderly, and its negative impact on physical function make it a leading cause of disability in the elderly. Joint pain as well joint stiffness are the common classic signs of OA. Chondrocyte death together with loss of articular cartilage integrity are the main pathologic changes in OA. Non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids are commonly used for the management of OA; still, their effectiveness is limited, and no therapeutic strategy is able to fully stop OA progression. Ferroptosis is a kind of cell death, distinct from apoptosis and necroptosis, caused by iron-dependent peroxidation of membrane phospholipids that terminates cell life by disintegrating all plasma membranes. It has been suggested that ferroptosis has a critical role in decreased viability of chondrocytes in OA, and here, we review recent findings regarding the pathologic pathways that lead to chondrocyte ferroptosis, and discuss the possible therapeutic utility of ferroptosis inhibition in OA.

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Acknowledgements

The authors declare that no funds, grants or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Nursing, Al-Maarif University College, Ramadi, Iraq

    Hussein Riyadh Abdul Kareem Al-Hetty

  2. Department of Biology, College of Education for Pure Sciences, Wasit University, Kut, Iraq

    Sada Jasim Abdulameer

  3. Department of Dentistry, Al-Rafidain University College, Baghdad, Iraq

    Maha Waleed Alghazali

  4. College of Dentistry, National University of Science and Technology, Dhi Qar, Iraq

    Fatime Satar Sheri

  5. Department of Biophysics, College of Applied Sciences, University of Anbar, Ramadi, Iraq

    Marwan Mahmood Saleh

  6. Department of Medical Laboratory Technology, College of Medical Technology, The Islamic University, Najaf, Iraq

    Marwan Mahmood Saleh

  7. Department of Medical Laboratories Techniques, Al-Mustaqbal University College, Hilla, Babylon, Iraq

    Abduladheem Turki Jalil

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  1. Hussein Riyadh Abdul Kareem Al-Hetty
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  2. Sada Jasim Abdulameer
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Contributions

HRAKA-H, SJA, MWA participated in the preparation of the manuscript. All authors read and approved the final document. all authors coordinated and supervised the production of the final document. FSS, MMS, ATJ reviewed and revised the manuscript according to editor's comments. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Hussein Riyadh Abdul Kareem Al-Hetty or Abduladheem Turki Jalil.

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Al-Hetty, H.R.A.K., Abdulameer, S.J., Alghazali, M.W. et al. The Role of Ferroptosis in the Pathogenesis of Osteoarthritis. J Membrane Biol 256, 223–228 (2023). https://doi.org/10.1007/s00232-023-00282-0

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  • DOI: https://doi.org/10.1007/s00232-023-00282-0

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