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Development of biosensors for detection of fibrinogen: a review

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Abstract

Fibrinogen as a major inflammation marker and blood coagulation factor has a direct impact on the health of humanity. The variations in fibrinogen content lead to risky conditions such as bleeding and cardiovascular diseases. So, accurate methods for monitoring of this glycoprotein are of high importance. The conventional methods, such as the Clauss method, are time consuming and require highly specialized expert analysts. The development of fast, simple, easy to use, and inexpensive methods is highly desired. In this way, biosensors have gained outstanding attention since they offer means for performing analyses at the points-of-care using self-testing devices, which can be applied outside of clinical laboratories or hospital. This review indicates that different electrochemical and optical sensors have been successfully implemented for the detection of fibrinogen under normal levels of fibrinogen in plasma. The biosensors for the detection of fibrinogen have been designed based on the quartz crystal microbalance, field-effect transistor, electrochemical impedance spectroscopy, amperometry, surface plasmon resonance, localized surface plasmon resonance, and colorimetric techniques. Also, this review demonstrates the utility of the application of nanoparticles in different detection techniques.

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Acknowledgements

The authors gratefully acknowledge the Faculty of Medicine, and Research and Development Institute of Transilvania University of Brasov, Romania, for supporting this work.

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Authors and Affiliations

  1. Department of Fundamental, Prophylactic and Clinical Disciplines, Faculty of Medicine, Transilvania University of Brasov, Brașov, Romania

    Arash Mohammadinejad, Lorena Dima & Mihaela Badea

  2. Research Center for Fundamental Research and Prevention Strategies in Medicine, Research and Development Institute of Transilvania University of Brasov, Brașov, Romania

    Arash Mohammadinejad, Lorena Dima & Mihaela Badea

  3. Department of Medical Biotechnology and Nanotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Ghazaleh Aleyaghoob & Samin Nooranian

  4. Department of Chemistry, Payame Noor University, Tehran, 19395-4697, Iran

    Ghazaleh Aleyaghoob

  5. Department of Medical and Surgical Specialties, Faculty of Medicine, Transilvania University of Brasov, Brașov, Romania

    Marius Alexandru Moga

  6. Centre for Applied Medicine and Intervention Strategies in Medical Practice, Research and Development Institute of Transilvania University of Brasov, Brașov, Romania

    Marius Alexandru Moga

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  1. Arash Mohammadinejad
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  2. Ghazaleh Aleyaghoob
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Correspondence to Mihaela Badea.

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Mohammadinejad, A., Aleyaghoob, G., Nooranian, S. et al. Development of biosensors for detection of fibrinogen: a review. Anal Bioanal Chem 416, 21–36 (2024). https://doi.org/10.1007/s00216-023-04976-1

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