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A PVDF-based colorimetric sensor array for noninvasive detection of multiple disease-related volatile organic compounds

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Abstract

Detection of human-generated volatile organic compounds (VOCs) is a new pathway for assessing health. Herein, a polyvinylidene fluoride (PVDF)-based colorimetric sensor array was designed for detecting disease-related VOCs (DVOCs) within 15 min, using a complex of Cu metal–organic framework, graphene aerogel, and dyes as response materials. Fingermaps derived from 28 DVOCs were obtained for further data processing. Pattern recognition was successfully employed in the correct discrimination of 28 DVOCs in low (10 μM), medium (100 μM), and high (300 μM) concentrations. Importantly, the sensor array also presented excellent discrimination ability and application potential when detecting VOCs produced by human cancer and normal cells. In general, VOC acquisition is noninvasive and harmless, and the PVDF-based sensor arrays are simple and visual. Such advantages expand their further application potential.

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Acknowledgements

This work was supported by the Chongqing Natural Science Foundation (CSTB2023NSCQ-BHX0078), Research projects of Wanzhou, China (wzstc20220314), Graduate Scientific Research and Innovation Foundation of Chongqing, China (CYS23136), National Facility for Translational Medicine (Shanghai) Open Research Fund (TMSK-2021-113), Chongqing Graduate Tutor Team Construction Project, Analytical and Testing Center of Chongqing University for TEM and the sharing fund of Chongqing University's large equipment.

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  1. Jingzhou Hou and Xiaofang Liu contributed equally to this work.

Authors and Affiliations

  1. Postdoctoral Research Station, Chongqing University, Bioengineering College of Chongqing University, Chongqing, 400044, People’s Republic of China

    Jingzhou Hou, Changjun Hou & Danqun Huo

  2. Key Laboratory for Biorheological Science and Technology of Ministry of Education, Bioengineering College of Chongqing University, Chongqing, 400044, People’s Republic of China

    Jingzhou Hou & Xiaofang Liu

  3. Chongqing Key Laboratory of Bio-Perception & Intelligent Information Processing, School of Microelectronics and Communication Engineering, Chongqing University, Chongqing, 400044, People’s Republic of China

    Danqun Huo

  4. Three Gorges Hospital of Chongqing University, Chongqing Municipality Clinical Research Center for Geriatric Diseases, Chongqing, 404000, People’s Republic of China

    Jiawei Li

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  1. Jingzhou Hou
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Hou, J., Liu, X., Hou, C. et al. A PVDF-based colorimetric sensor array for noninvasive detection of multiple disease-related volatile organic compounds. Anal Bioanal Chem 415, 6647–6661 (2023). https://doi.org/10.1007/s00216-023-04941-y

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