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Hydrogel-based holographic sensors and biosensors: past, present, and future

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Abstract

Hydrogel-based holographic sensors consist of a holographic pattern in a responsive hydrogel that diffracts light at different wavelengths depending on the dimensions and refractive index changes in the material. The material composition of hydrogels can be designed to be specifically responsive to different stimuli, and thus the diffraction pattern can correlate with the amount of analyte. According to this general principle, different approaches have been implemented to achieve label-free optical sensors and biosensors, with advantages such as easy fabrication or naked-eye detection. A review on the different approaches, sensing materials, measurement principles, and detection setups, and future perspectives is offered.

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Acknowledgement

This work was financially supported by the E.U. FEDER, the Spanish Ministry of Economy and Competitiveness MINECO (AdBiHol- PID2019-110713RB-I00) and the Generalitat Valenciana (PROMETEO/2020/094). M. I. Lucío acknowledges MINECO for her Juan de la Cierva-formación and -incorporación grants (FJCI-2016-29593, IJC2018-035355-I).

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  1. Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM), Polytechnic University of Valencia, Camino de Vera s/n, 5M, 46022, Valencia, Spain

    María Isabel Lucío, Aitor Cubells-Gómez, Ángel Maquieira & María-José Bañuls

  2. Department of Chemistry, Polytechnic University of Valencia, Camino de Vera s/n, 5M, 46022, Valencia, Spain

    Ángel Maquieira & María-José Bañuls

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  1. María Isabel Lucío
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Lucío, M.I., Cubells-Gómez, A., Maquieira, Á. et al. Hydrogel-based holographic sensors and biosensors: past, present, and future. Anal Bioanal Chem 414, 993–1014 (2022). https://doi.org/10.1007/s00216-021-03746-1

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