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Application of the poly (POSS-octavinyl-co-N-methylacetamide-co-divinylbenzene) solid extraction column in analyzing preservatives

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Abstract

In this study, a special poly solid-phase extraction (in-tube SPE) column consisting of poly (POSS-octavinyl-co-N-methylacetamide-co-divinylbenzene) [poly (POSS-OS-co-DVB-co-NMA)] was prepared based on the chemical structure of the preservatives, and was used as medium for extraction analysis in combination with UPLC. The composition of polymer SPE was optimized and characterized; good scanning electron microscopy (SEM) properties and satisfactory porosity were obtained with 30% monomer (POSS-OS:DVB:NMA = 2 wt%:13 wt%:15 wt%) and 70 wt% porogenic solvent (PEG20000:DMSO:ACN = 10 wt%:50 wt%:10 wt%). The experimental parameters of the in-tube SPE-UPLC analysis were optimized systematically. Then, the in-tube SPE-UPLC method was applied for analyzing the beverage sample, and correlation coefficients (R2) > 0.99 were obtained for the linear relationship within limits of 0.1~5.0 μg mL−1. Excellent extraction efficiency, good precision, and satisfactory limit of detection sensitivity between 0.03 and 0.10 μg mL−1 were obtained. The recovery ranged from 71.5 to 88.0%, with RSD ≤ 6.1%. Furthermore, the proposed method has the features of simple sample pretreatment, high throughput, rapid analysis, cost-effectiveness, and satisfactory sensitivity. Hence, the developed in-tube SPE-UPLC method based on the poly (POSS-OS-co-DVB-co-NMA) SPE column can be potentially used for simple and sensitive detection of preservatives.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (22004074, 21927805, and 21803013), the Public Welfare Fund Project of Ningbo (202002N3113), the National Key Research and Development Program of China (2020YFF01014601), and the K. C. Wong Magna Fund in Ningbo University.

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  1. Zhejiang Provincial Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis, Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo, 315211, Zhejiang, China

    Pingping Wang, Fangling Wu, Jun Jack Hu & Chuan-Fan Ding

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  1. Pingping Wang
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  2. Fangling Wu
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  3. Fuxing Xu
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  4. Jun Jack Hu
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  5. Chuan-Fan Ding
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Correspondence to Fangling Wu, Jun Jack Hu or Chuan-Fan Ding.

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Wang, P., Wu, F., Xu, F. et al. Application of the poly (POSS-octavinyl-co-N-methylacetamide-co-divinylbenzene) solid extraction column in analyzing preservatives. Anal Bioanal Chem 414, 1493–1501 (2022). https://doi.org/10.1007/s00216-021-03613-z

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