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Recent applications of mass spectrometry in bacterial lipidomics

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Abstract

The popularity of mass spectrometry–based lipidomics has soared in the past decade. While the majority of the lipidomics work is being performed in mammalian and other eukaryotic systems, there is also a growing rise in the exploration of bacterial lipidomics. The lipids found in bacteria can be substantially different from those in eukaryotic systems, but they are equally important for maintaining the structure of the bacteria and providing protection from the surrounding environment. In this article, recent applications of lipidomics in combination with molecular biology and applications in microbial strain identification and antibiotic susceptibility are highlighted. The authors’ perspectives on current challenges facing the field and future directions are also provided.

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Funding

This work was supported by start-up funds from the University of Georgia Office of Research, the Franklin College of Arts and Sciences, and the Department of Chemistry.

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  1. Keerthi Appala, Kingsley Bimpeh and Christian Freeman contributed equally to this work.

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  1. Department of Chemistry, University of Georgia, 140 Cedar Street, Athens, GA, 30602, USA

    Keerthi Appala, Kingsley Bimpeh, Christian Freeman & Kelly M. Hines

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  1. Keerthi Appala
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Correspondence to Kelly M. Hines.

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Appala, K., Bimpeh, K., Freeman, C. et al. Recent applications of mass spectrometry in bacterial lipidomics. Anal Bioanal Chem 412, 5935–5943 (2020). https://doi.org/10.1007/s00216-020-02541-8

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