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Micro-solid-phase extraction coupled to desorption electrospray ionization–high-resolution mass spectrometry for the analysis of explosives in soil

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Abstract

Home-made micro-solid-phase extraction (SPE) cartridges using different adsorbent materials were tested for the desorption electrospray ionization–high-resolution mass spectrometry (DESI-HRMS) determination of explosives like 2,4,6-trinitrotoluene, cyclotrimethylene-trinitramine, cyclotetramethylene-tetranitramine, pentaerythritol tetranitrate, and trinitrophenylmethylnitramine in soil samples. Quantitation limits in the low nanogram per kilogram range proved the reliability of the method for the detection of explosives at ultra-trace levels. The reduced sample preparation allowed for low costs and high-throughput analyses. Finally, the superior extraction capability of the method was proved by obtaining DESI-HRMS responses at least five times higher than those achieved by performing DESI-HRMS analyses of solid–liquid extracts spotted onto commercial polytetrafluoroethylene slides.

DESI-HRMS analysis of explosives from soil samples

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Authors and Affiliations

  1. Dipartimento di Chimica, Università degli Studi di Parma, Parco Area delle Scienze 17/A, 43124, Parma, Italy

    Federica Bianchi & Maria Careri

  2. Reparto Carabinieri Investigazioni Scientifiche di Roma, Viale di Tor di Quinto n.119, 00191, Rome, Italy

    Adolfo Gregori

  3. IVA Analysentechnik, E. K., Alte Seilerei, Haus 5, Meerbuscher Str. 64-78, 40670, Meerbusch, Germany

    Gabriele Braun

  4. Dipartimento di Farmacia, Università di Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy

    Carlo Crescenzi

Authors
  1. Federica Bianchi
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  2. Adolfo Gregori
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  3. Gabriele Braun
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  4. Carlo Crescenzi
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  5. Maria Careri
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Corresponding author

Correspondence to Federica Bianchi.

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Published in the topical collection celebrating ABCs 13th Anniversary.

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Bianchi, F., Gregori, A., Braun, G. et al. Micro-solid-phase extraction coupled to desorption electrospray ionization–high-resolution mass spectrometry for the analysis of explosives in soil. Anal Bioanal Chem 407, 931–938 (2015). https://doi.org/10.1007/s00216-014-8208-7

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  • DOI: https://doi.org/10.1007/s00216-014-8208-7

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