Abstract
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic factors for both ailments. These diseases share common pathogenetic mechanisms including inflammation, oxidative stress, and tissue remodelling. Current therapeutic approaches are limited by low efficacy and adverse effects. Consequentially, LC has a 5-year survival of < 20%, while COPD is incurable, underlining the necessity for innovative treatment strategies. Two promising emerging classes of therapy against these diseases include plant-derived molecules (phytoceuticals) and nucleic acid-based therapies. The clinical application of both is limited by issues including poor solubility, poor permeability, and, in the case of nucleic acids, susceptibility to enzymatic degradation, large size, and electrostatic charge density. Nanoparticle-based advanced drug delivery systems are currently being explored as flexible systems allowing to overcome these limitations. In this review, an updated summary of the most recent studies using nanoparticle-based advanced drug delivery systems to improve the delivery of nucleic acids and phytoceuticals for the treatment of LC and COPD is provided. This review highlights the enormous relevance of these delivery systems as tools that are set to facilitate the clinical application of novel categories of therapeutics with poor pharmacokinetic properties.
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Funding
Kamal Dua is supported by a project grant from the Rebecca L. Cooper Medical Research Foundation and the Maridulu Budyari Gumal Sydney Partnership for Health, Education, Research and Enterprise (SPHERE) Triple I Seed grant, RSEOH CAG Seed grant, fellowship, and extension grant; Faculty of Health MCR/ECR Mentorship Support Grant and UTS Global Strategic Partnerships Seed Funding Scheme. Gabriele De Rubis is supported by the Triple I Clinical Academic Group (CAG) Secondment/Exchange Program grant. Keshav Raj Paudel is supported by a fellowship from Prevent Cancer Foundation (PCF) and the International Association for the Study of Lung Cancer (IASLC). Kamal Dua, Keshav Raj Paudel, and Gabriele De Rubis are also supported by UTS 2023 Key Technology Partner (KTP) grants.
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GDR and KD conceived the idea of the literature review. All the listed authors contributed to the writing of the first draft of the manuscript and to the subsequent revisions and finalisation of the manuscript. KD supervised the project. The authors confirm that no paper mill and artificial intelligence was used.
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De Rubis, G., Paudel, K.R., Corrie, L. et al. Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease. Naunyn-Schmiedeberg's Arch Pharmacol 397, 2793–2833 (2024). https://doi.org/10.1007/s00210-023-02830-w
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DOI: https://doi.org/10.1007/s00210-023-02830-w