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Nanocarriers: An Advanced and Highly Effective Approach for Targeting Chronic Lung Diseases

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Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases

Abstract

With aging communities, respiratory disorders are creating an alarming situation due to the scarcity of facilities and socio-medical insurances. Among these, the CLDs are expected to be among the top four causes of death across the globe. The conventional management for these diseases includes strategies manipulating miRNA, siRNA, shRNA and drugs used in the treatment.

As these require longer, sometimes lifelong treatment, there is an urgent need to formulate strategies to reduce toxicity arising from such strategies. With the advancement of knowledge and technologies, it is now known that small-sized particles result in better distribution and surface area to volume ratio. This has dawned on an era of nanotechnological research and development and their applications in the field of therapeutics.

As a finer approach, nanoscale transports, of different types like liposomes, dendrimers, quantum dots, for targeted drug delivery have stabilized themselves quite effectively in the pharmaceutical therapy as discussed in detail in this chapter.

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Abbreviations

CILD:

Chronic inflammatory lung Diseases

CLD:

Chronic lung diseases

CNT:

Carbon nanotubes

COPD:

Chronic obstructive pulmonary disease

DNA:

Deoxyribonucleic acid

IPF:

Idiopathic pulmonary fibrosis

MWNTs:

Multi-walled nanotubes

PLGA:

Poly(lactic-co-glycolic) acid

QDs:

Quantum dots

SLNs:

Solid lipid nanoparticles

SWNTs:

Single-walled nanotubes

TPP:

Tripolyphosphate

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Author notes

  1. Anand Maurya and Anurag Kumar Singh contributed equally to this work.

Authors and Affiliations

  1. Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Anand Maurya

  2. Centre of Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Anurag Kumar Singh

  3. Department of Pharmacy, NKBR College of Pharmacy & Research Centre, Meerut, Uttar Pradesh, India

    Bhuwanendra Singh

  4. Department of Pharmacology, Varanasi College of Pharmacy, Varanasi, Uttar Pradesh, India

    Nidhi Singh

  5. K J College of Pharmacy, Varanasi, Uttar Pradesh, India

    Sachin Kumar Agrahari

  6. Department of Pharmacy, Hygia Institute of Pharmaceutical Education and Research, Lucknow, Uttar Pradesh, India

    Arati Rai

  7. S P College of Pharmaceutical Sciences and Research, Bijnor, Uttar Pradesh, India

    Gopal Kumar Rai

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  1. Anand Maurya
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  2. Anurag Kumar Singh
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  3. Bhuwanendra Singh
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Editors and Affiliations

  1. Department of Life Sciences, International Medical University, Kuala Lumpur, Malaysia

    Dinesh Kumar Chellappan

  2. Regulatory Affairs Coordinator, Bioproperties Pty Ltd, Glenorie, NSW, Australia

    Kavita Pabreja

  3. School of Pharmacy, Al-Karim University, Katihar, Bihar, India

    Md. Faiyazuddin

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Maurya, A. et al. (2022). Nanocarriers: An Advanced and Highly Effective Approach for Targeting Chronic Lung Diseases. In: Chellappan, D.K., Pabreja, K., Faiyazuddin, M. (eds) Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases . Springer, Singapore. https://doi.org/10.1007/978-981-16-4392-7_6

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