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Dopamine D1 receptor antagonist reduces stimulant-induced conditioned place preferences and dopamine receptor supersensitivity

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A Correction to this article was published on 22 November 2019

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Abstract

Repeated administration of stimulants induces conditioned place preference (CPP). Dopamine receptor supersensitivity is developed in stimulant-induced CPP animals; however, dopamine receptor subtypes associated with the development of supersensitivity in CPP animals are largely unknown. The present preclinical study aimed to examine whether dopamine D1 or D2 receptor antagonists exert inhibitory effects on stimulant-induced psychological behaviors. Additionally, the authors aimed to elucidate the role of dopamine receptor supersensitivity on the development of reward-related behavior. Sprague Dawley rats subjected to methamphetamine- and cocaine-induced CPP tests were treated with dopamine D1 (SCH23390) or D2 (sulpiride) receptor antagonists. Following the CPP experiment, rats were challenged with apomorphine (dopamine receptor agonist), and locomotor activity was measured. Methamphetamine- and cocaine-induced CPP was reduced with the administration of SCH23390, but not sulpiride. In addition, the apomorphine challenge evoked an increase in locomotor activity in stimulant-pre-treated rats, reflecting dopamine receptor supersensitivity. SCH23390 pre-treatment inhibited the development of dopamine receptor supersensitivity, while sulpiride demonstrated no inhibitory effects. These results suggest that the dopamine D1 receptor antagonist SCH23390 inhibits the development of dopamine receptor supersensitivity which is associated with the development of CPP.

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Change history

  • 22 November 2019

    In the originally published article, the name of the first author was incorrectly presented as Su Mi Gu. The correct name is Sun Mi Gu, which is also given above.

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Funding

This study was supported by the National Research Foundation of Korea (2017R1C1B5017929) and the research grant of the Chungbuk National University in 2018.

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Author notes

  1. Sun Mi Gu and Hye Jin Cha contributed equally to this work.

Authors and Affiliations

  1. College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk, 28160, Republic of Korea

    Sun Mi Gu, So Woon Seo, Jin Tae Hong & Jaesuk Yun

  2. National Institute of Food and Drug Safety Evaluation, 187, Osongsaengmyeong 2-ro, Heungdeok-gu, Cheongju, Chungbuk, 28159, Republic of Korea

    Hye Jin Cha

Authors
  1. Sun Mi Gu
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  2. Hye Jin Cha
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  3. So Woon Seo
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  4. Jin Tae Hong
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  5. Jaesuk Yun
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Contributions

JTH and JSY were responsible for the study concept and design. SMG performed experiments and drafted the manuscript. HJC performed data analysis and drafted the manuscript. SWS drafted the manuscript. All authors critically reviewed the content and approved the final version for publication.

Corresponding authors

Correspondence to Jin Tae Hong or Jaesuk Yun.

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The authors declare that they have no conflict of interest.

Ethical approval

All animals were treated in Association for Assessment and Accreditation of Laboratory Animal Care International-accredited facilities, operating according to the Guide for the Care and Use of Laboratory Animals. All experiments were approved by the Institutional Animal Care and Use Committee of Chungbuk National University.

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The original version of this article was revised; In the originally published article, the name of the first author was incorrectly presented as Su Mi Gu. The correct name is Sun Mi Gu, which is also given above.

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Gu, S.M., Cha, H.J., Seo, S.W. et al. Dopamine D1 receptor antagonist reduces stimulant-induced conditioned place preferences and dopamine receptor supersensitivity. Naunyn-Schmiedeberg's Arch Pharmacol 393, 131–138 (2020). https://doi.org/10.1007/s00210-019-01694-3

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