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Renoprotective effect of lansoprazole in streptozotocin-induced diabetic nephropathy in wistar rats

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Abstract

Proton pump inhibitors (PPIs) have exhibited glucose lowering action in animal models of diabetes; however, their potential in diabetes-related complications has not yet been evaluated. Hence, the present study has been undertaken to investigate the renoprotective potential of lansoprazole in streptozotocin-induced diabetic nephropathy in wistar rats. Diabetic nephropathy was induced with a single injection of streptozotocin (STZ, 45 mg/kg, i.p.). Lansoprazole (40 mg/kg; 80 mg/kg, p.o.; 4 weeks) was administered to diabetic rats after 4 weeks of STZ treatment. A battery of biochemical tests such as serum glucose, glycated hemoglobin, blood urea nitrogen (BUN), serum creatinine, albumin, and kidney weight/body weight (%) ratio were performed to evaluate the renal functions. Oxidative stress was determined by estimating renal thiobarbituric acid reactive species (TBARS) and reduced glutathione (GSH) levels. Lipid profile was assessed by determining serum cholesterol (TC), triglyceride (TG), and high-density lipoprotein (HDL). The STZ-treated rats demonstrated deleterious alterations in kidney functions, enhanced oxidative stress, and disturbed lipid profile. Administration of lansoprazole to diabetic rats significantly reduced serum glucose, glycated hemoglobin, BUN, creatinine, albumin levels, and oxidative stress. Serum lipids like TC and TG were decreased, and HDL was enhanced in lansoprazole-treated STZ rats. The findings of our study indicate that renoprotective effects of lansoprazole may be attributed to its glucose-lowering, lipid-lowering, and antioxidative potential.

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Acknowledgments

The authors are thankful to Chandigarh College of Pharmacy, Landran, Mohali, India, for providing the financial support and encouragement.

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  1. Pharmacology Division, Chandigarh College of Pharmacy, Landran, Mohali, Punjab, 140307, India

    Rupinder Kaur, Rupinder Kaur Sodhi, Neha Aggarwal, Jaspreet Kaur & Upendra K. Jain

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Kaur, R., Sodhi, R.K., Aggarwal, N. et al. Renoprotective effect of lansoprazole in streptozotocin-induced diabetic nephropathy in wistar rats. Naunyn-Schmiedeberg's Arch Pharmacol 389, 73–85 (2016). https://doi.org/10.1007/s00210-015-1182-6

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